Conserved Protein Domain Family
PBP1_BmpA_PnrA_like

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cd06354: PBP1_BmpA_PnrA_like 
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Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea
Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea. The PnrA lipoprotein, also known as Tp0319 or TmpC, represents a novel family of bacterial purine nucleoside receptor encoded within an ATP-binding cassette (ABC) transport system (pnrABCDE). It shows a striking structural similarity to another basic membrane lipoprotein Med which regulates the competence transcription factor gene, comK, in Bacillus subtilis. The members of PnrA-like subgroup are likely to have similar nucleoside-binding functions and a similar type I periplasmic sugar-binding protein-like fold.
Statistics
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PSSM-Id: 107349
View PSSM: cd06354
Aligned: 122 rows
Threshold Bit Score: 207.366
Threshold Setting Gi: 13959586
Created: 11-Jul-2007
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
ligand binding
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              ##        #                                                               
2FQW_A         6 VVGMVTDSgdidDKSFNQQVWEGISRFAqe--nNAKCKYVTas----tdAEYVPSLSAFADE----NMGLVVACgsf--- 72
gi 119718414  39 KVGIFVDNaf-gDGDFFDQAAKAEEPLKte--qGATVETYEgq----lqAQNFEPLLQDAAD----ANDLVFVLgfe--- 104
gi 1753226    29 KISMLVDGvl-dDKSFNSSANEALLRLKkd--fPENIEEVFscaisgvySSYVSDLDNLKRN----GSDLIWLVgym--- 98
gi 18310291   43 NFALVKDDfsneENYFTDLAVDGLERIKke--yGARIEVFD--------TNSSEDYEKRLREaa-qNNDLTFASafk--- 108
gi 157363539  22 KVAYVINGsl-gDQSFYDSGYAGIKELEer--yGVQTRVVE--------CNFDPSLYYPSLMtaaqWADVIFVIsyg--- 87
gi 23499777   35 KIMLIVNGtl-gDKSFFDSAANGMKMIKdkygdEVETRILEigd---dpTKWEPVLLDASEQ----DWDLIIAGtyq--- 103
gi 120537057  26 APAILFNStivlDDSYNESLLAGMEQFEqq--kGVPFAQVAta----dpILYRQSLESLAMA----GHSPIIVPggg--- 92
gi 157363882  22 KVALLLNGrl-gDKSFLDSAGRGLEMAVee--lGIQGKVIEany---npANWRPYLEDISDQ----DYDVIIVGtwq--- 88
gi 118725673  48 GIALITSAagpnDKGYNQSAIAGLEKAKkd--lGIKYKVVEt-------TDVPGSLSQLAGA----GYKLIFSLeynfda 114
gi 162148470  15 HAVLVVGQgglgDQSYNDLGTAGFLQGVrd--iGVTGRIVEtas---vvSEGADILRQAAAA----GFGLIVDLeya--- 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                               #                                                        
2FQW_A        73 ---lveAVIETSARfpKQKFLVIDavvqd-------rdnvvSAVFGQNEGSFLVGVAAAlkak---------------ea 127
gi 119718414 105 ---aidAMVKVAGEnpDTTFVFIDgvvds--------pevvSAEFRTAEGCFMAGALAAtvnq---------------sa 158
gi 1753226    99 ---ltdASLLVSSEnpKISYGIIDpiygddv---qipenliAVVFRVEQGAFLAGYIAAkks------------------ 154
gi 18310291  109 ---fleSLNNVAKDypDKNFAIVDtvsdl--------pnvkSIDFKDEEGAFLMGIIAGntt------------------ 159
gi 157363539  88 ---feeELKEIAMKfpDKIWVNIDtvvqde------kgvisSVDYREEEGAFLAGVVAAittnmte---------lagin 149
gi 23499777  104 ---maeTVGSVAQQypDKKYILYDasvpyee---ggydnvySIQYKQNEGSYLGGLLAAsllkeg-----------klgd 166
gi 120537057  93 ---tqsIVETVAPSfpHTTFISIGyqtda--------pnvrSILFREWEGAYLAGVLAAyrs------------------ 143
gi 157363882  89 ---mqeILEEVAPMhpEKKYFIFDasvdynk---skldnvySMIYKQNEGSFLAGALAAlittsgi----------pktn 152
gi 118725673 115 likgvgGSKPIAEQypDTTFVIFNdnpnvnddgsvkhknvvSVLFDVHEASFMAGALATlvnenasklfnsseysftsgd 194
gi 162148470  83 ---hgaVIAEVAPQfaRCRFVTLNqvvhg--------pnitSILFQEQEGSYLAGVLAAaslrdra---------lpgld 142
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                       #                                 #                         #    
2FQW_A       128 gkSAVGFIVGmelgmMPLFEAGFEAGvkavd------pdiqVVVEVANTFsDPQKGQALAAKLYDSGVNVIFQVAGGTGN 201
gi 119718414 159 ssDTAGFIGGvnapvIKNCESGYTQGvtavd------pdqsVAAQYAGSFvDPAKGKEITIALGNKGAHAVFAYAGLTGA 232
gi 1753226   155 fsGKIGFIGGmkgniVDAFRYGYESGakyan------kdieIISEYSNSFsDVDIGRTIASKMYSKGIDVIHFAAGLAGI 228
gi 18310291  160 ktNKVGFIGAikeelIETFLSGFMAGlkvsneeayknirkgNLVQYIGNFnDQKKANDIAKKMYDEGADIIFESAGEAGK 239
gi 157363539 150 pqKIIGAVGGdddivIRSFVYGYEMGaryid------peiqVKVIYVGTWdDPSKGKQAALQLYAQGADVIFQIAALTGF 223
gi 23499777  167 gaKNLGFLGGmdipvINDFLVGYIAGaqsvi------pdakIAVSYAGSFmDAAKGKELGLAQYRSGVSLGFVVASQTGL 240
gi 120537057 144 pnRKVGFMGGlpvrsVKELEAGFRAGfnhvlpd-gqvtslyLSEYSDRPWdDESKARELGRQLFNSGHDIVFAAAGSSGK 222
gi 157363882 153 pePVIGFLGGvdipvINDFLVGYIEGakyvn------peikVLISYVGSFnDPAKGKEISLAMYRHGADIIFNVAANTGI 226
gi 118725673 195 agRKVGFLGGsksngITVFGYGFAEGinyvake--lgvnytFYSDYNAGFsDSASGATKANTYYSDGANIVYAVAGAVGD 272
gi 162148470 143 rhAGLGVIGGvrsagIDKFIVGFIQGarsid------pkitIHVAYANSFgDPALGFEMARAMYRGGVGIIYAVAGTTGI 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                             #                       #                                  
2FQW_A       202 GVIKEARDRrlngqdVWVIGVDRDQYMDGvydg--sksVVLTSMVKRADVAAERISKMAYdgsf--pggQSIMFGLeDKA 277
gi 119718414 233 GSFNAAKSGt----dVAPIGVVADKSSLAp-------gKSPGTLEMGVDSVILQTAEKYAagql--ekgTSSSFGFaEGG 299
gi 1753226   229 GVIEAAKNLgd---gYYVIGADQDQSYLAp-------kNFITSVIKNIGDALYLITGEYIknnn-vwegGKVVQMGlRDG 297
gi 18310291  240 GLFKAAKEKg-----KYAIGADIDWAERFpey----adVILSSMIKNLDDAVYTTAKEVInsdfkagpkNKMEIGLkDNG 310
gi 157363539 224 GVLQAAQEVg-----KYAIGVDSNQNPLAp-------gHVITSDLKEVGKSILMIYDMIVnnsf--ekgKIYSLGVkEGA 289
gi 23499777  241 GQLSAAKETg-----KYVLGVDSDQEAIFkdsdpaiakQVVSSVLKNIDVSLLQAYERYKagnl--pfgKAEALGLkEGA 313
gi 120537057 223 GALAAAAEAd-----KLAIGVDQNQNGLYp-------gHVLTSVVKHLDRAVYVALISERwql---wrsPVKRLGLaQGG 287
gi 157363882 227 GLLEAAKEVd-----RWVIGVDSDQALMYestdpeisnHIVTSMMKNVDNSIFRGLKLHLqgkl--gygQVESLGIaEGG 299
gi 118725673 273 GVDAKAKEVk-----KLSIEVDANKDSNQp-------gYILTSVLKNTEVPVYEIAKNYKenamdkvngKVLSYNLaTGA 340
gi 162148470 217 GAIRAARDMn-----RYAIGVDQDEDGLAp-------gHVLTSMVKHTDLAVRNVVRSWHdgtl--pddGVIRMGLaSGG 282

                 ...
Feature 1           
2FQW_A       278 VGI 280
gi 119718414 300 WAM 302
gi 1753226   298 VIG 300
gi 18310291  311 IEI 313
gi 157363539 290 VGL 292
gi 23499777  314 VGI 316
gi 120537057 288 VSI 290
gi 157363882 300 VGI 302
gi 118725673 341 TGI 343
gi 162148470 283 IGL 285

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