Conserved Protein Domain Family
PBP1_GPC6A-like

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cd06361: PBP1_GPC6A-like 
ligand-binding domain of the promiscuous L-alpha-amino acid receptor GPRC6A which is a broad-spectrum amino acid-sensing receptor
This family includes the ligand-binding domain of the promiscuous L-alpha-amino acid receptor GPRC6A which is a broad-spectrum amino acid-sensing receptor, and its fish homolog, the 5.24 chemoreceptor. GPRC6A is a member of the family C of G-protein-coupled receptors that transduce extracellular signals into G-protein activation and ultimately into cellular responses.
Statistics
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PSSM-Id: 380584
Aligned: 10 rows
Threshold Bit Score: 607.831
Created: 6-Jun-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative ligandputative dimer
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to the Rattus norvegicus mGluR subtype 1 complexed with glutamate

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                          #                                           
Q5T6X5      37 IIGGLFAIHEKMlssedsp----rrpqiqECVGFEISVFLQTLAMIHSIEMInnst--llpgVKLGYEIYDTCtevTVAM 110  human
Q5U9X3      36 IIGGLFPIHEAVvpvnytgnnsisapehpDCIRFYTKGLNQALAMINAVEMAnkspmlsslnITLGYRIYDTCsdvTTAL 115  zebrafish
Q9PW88      38 IIGGLFPIHEAAeavnftglnsfssfqhpVCNRYYTKGLNQALAMIHAVEMAnqspmlsslnLTLGYRIYDTCsdvTTAL 117  goldfish
NP_683766   37 IIGGLFAIHEKMlssedsp----rrpqiqECVGFEISVFLQTLAMIHSIEMInnst--llpgVKLGYEIYDTCtevTVAM 110  human
OCT80319    36 IIGGLFSVHGKImnsptgy---pnmpalqNCAGFEMQGFLQMLAMSHAIEMInnss--lipgIKLGYEIYDTCsevTMAL 110  African clawed frog
KTF79147    25 NIAILSSIHTKVidlhkr-----tkpqpfVCTGFDLTTFLQSLSAIHTIEEInnst--llpgIKLGYEVCDPCaspTKAL 97   common carp
KKF30996    43 EIGIMLPCHRKVtalhar-----itpesfHCSDFDLESFVKSLAVIHEIEEInaar--flpgVRLGYMMCDTCsyaSKAL 115  large yellow cro...
OCT80318    38 MIGGLFPIHKEIpdlgiy-----tkpsefICTGFDLRGFLRSLGMVHAIERInrfs--llpgIKLGYAIYDTCgdaSRGL 110  African clawed frog
Q70VB1      37 MIGGLFAIHEKMlssddhp----rqpqiqKCVGFEISVFLQTLAMIHSIEMInnss--llsgVKLGYEIYDTCtevTAAM 110  Norway rat
OCT80315    37 MIGGIFPIHSGVsnllqr-----ahaddfICTGLQLRFVVKALSMMYMIESInnst--llpgIKLGYEIYDSCsdvFKAV 109  African clawed frog
Feature 1                                                                 ##                   
Q5T6X5     111 AATLRFLSKFNCSretvefkcdyssYMPRVKAVIGSGySEITMAVSRMLNLQLMPQVGYESTAeILSDKIRFPSFLRTVP 190  human
Q5U9X3     116 RAVHDIMRPFSDCespe----dssqPVQPIMAVIGTTsSEISIAVARDLNLQMIPQISYASTAtILSDKSRFPAFMRTVP 191  zebrafish
Q9PW88     118 WAVQDLTRPYSYCdsqt----nssqPVQPIMAVIGPSsSEISIAVARELNLLMIPQISYASTAtILSDKSRFPAFMRTVP 193  goldfish
NP_683766  111 AATLRFLSKFNCSretvefkcdyssYMPRVKAVIGSGySEITMAVSRMLNLQLMPQVGYESTAeILSDKIRFPSFLRTVP 190  human
OCT80319   111 SATMRLLSAFNSSednlkfkcnyttYTPKVKAIIGDSySEVSIAVARLLNTQLIPLVSHSSSAeILSDKFRFPTFLRTIP 190  African clawed frog
KTF79147    98 HCVEHLLAINGSLpalv----dytdFRAPVKALLGERySELSIAIAKLLSLYLHPQISCSSSSpVLSDKLRYPSFMRVIP 173  common carp
KKF30996   116 QNVGHMLAVNMSLnvkc----dytdFRPRVKIIVGALySEVSIAVARLLNVYMVTLLSGTSSSpELSDKTRFPVFMRTIP 191  large yellow cro...
OCT80318   111 QETIKLTGYQDSSygilhgicnvtdRPPLVKAVVGASySEVSIAVARLLGFQLVPQISYGSSAaILSDKRRFPSFLRTVP 190  African clawed frog
Q70VB1     111 AATLRFLSKFNCSretvifqcdyssYVPRVKAIIGAGySEISMAVSRMLNLQLMPQVSYESTAeILSDKIRFPSFLRTVP 190  Norway rat
OCT80315   110 QSTVKLFPELETWnnlls--snnteKTPTVKAVIGETfSELSIAISRILSLHSIPQISLESSVpSLSDKLRFPSFLRTVP 187  African clawed frog
Feature 1                                                                                      
Q5T6X5     191 SDfHQIKAMAHLIQksgWNWIGIITTDDDYGRLALNTFIIQAEANnVCIAFKEVLPAFLSDnti-evrINRTLKKIILEa 269  human
Q5U9X3     192 SDeYQTCAMAKLLKsnkWSWVGIIITDGDYGRSALEGFIQHTETEgICIAFKAILPDSLADqqklntdIENTLNIIENNp 271  zebrafish
Q9PW88     194 NDeYQTHAMVQLLKdnkWTWVGIIITDGDYGRSAMESFVKHTEREgICVAFKVILPDSLADeqklnihINETVDIIEKNt 273  goldfish
NP_683766  191 SDfHQIKAMAHLIQksgWNWIGIITTDDDYGRLALNTFIIQAEANnVCIAFKEVLPAFLSDnti-evrINRTLKKIILEa 269  human
OCT80319   191 NDfHQTRAMAKLIHisgWNWIGLIAMDDDYGRSALESFGAQSMKInVCIAFKHIIPAHLSDstv-qskINKTIMTIQMEs 269  African clawed frog
KTF79147   174 SDvYQAQALVNLMShfsWNWVGVVYGDDDYGRAAYQSFMEESQGK-ICADFEKVVPHYLDHvdm-dkhIKDVAQSIQKSg 251  common carp
KKF30996   192 SDkHQTKAVARFMHhfdWNWVGVVYGDDDYGRAAFQSFLRDADVNsVCLAYQEVVPHYLDHahs-mqrIKEVAQRIRSSd 270  large yellow cro...
OCT80318   191 SDvHMTKALSKLISqfkWSYVGLISSDDDYGRSILESLAMQFDNKfVCIAFEEKLPADIGNpgv-nvsIKAVIGTIKQSp 269  African clawed frog
Q70VB1     191 SDfYQTKAMAHLIRqsgWNWVGAITTDDDYGRLALNTFAIQAAENnVCIAFKEVLPAFLSDnti-evrINQTLEKIIAEa 269  Norway rat
OCT80315   188 SDkHQTRAIAKLIRtfgWNWVGIISSDDDYGQSAADLLNIYLEQEmICTAFSKILPSNVGHpsm-kkkITDLISELNSSs 266  African clawed frog
Feature 1                                                                                      
Q5T6X5     270 qVNVIVVFlrqfhVFDLFNKAIEMni--nKMWIASDNWSTatkittiPNVKKIGKVVGFAFrrGNISSFHSFLQNLhllp 347  human
Q5U9X3     272 kVRVVISFakssqMQLLFKGLQSRnisnnMVWVASDNWSTakhilndGSITDIGKVLGFTFksGNFTSFHQYLKNLqfes 351  zebrafish
Q9PW88     274 kVNVVVSFakssqMKLLYEGLRSRnvpknKVWVASDNWSTsknilkdVNLSDIGNILGFTFksGNVTAFLQYLKDLkfgs 353  goldfish
NP_683766  270 qVNVIVVFlrqfhVFDLFNKAIEMni--nKMWIASDNWSTatkittiPNVKKIGKVVGFAFrrGNISSFHSFLQNLhllp 347  human
OCT80319   270 rVNIIVVFlkpslVIKLFKRVIELni--qKTWIASDIWSAattissiPNIQRVGRVIGFTFksGAISPFLNYLKNLnrqh 347  African clawed frog
KTF79147   252 -AKVVLLIlkpqlVEKLFKEMIQTnt--sRIWIASDAWSMnryltkmKDINKVGKIFGFSFsmGIIPGFEDYLKNLrptp 328  common carp
KKF30996   271 -AQVVLLIlkadlVKALFKEMIRTkt--sRTWIASDSWSRnwllaqmDGINEVGDILGFTFiaGKSESFDNYLKNLtatp 347  large yellow cro...
OCT80318   270 -AKVVILAlkvpiVMELFNEVLKQni--sRVWIATDNWSTsqevaamPDIEHVGNILGFSFenREVPGFRMYLRSLsagp 346  African clawed frog
Q70VB1     270 qVNVIVVFlrkfhVFNLFNKAIERki--sKIWIASDNWSTaakiitiPNVKKLGKVVGFTFrrGNMSSFHSFLQTLhmyp 347  Norway rat
OCT80315   267 -ANAIIIIakgptVINVFQEVIRMni--sKIWIATDIWSTsrevlnmKDIAKVGVIFGLMFqaKLVQGFTEYLQNLqlpp 343  African clawed frog
Feature 1                                                                                #     
Q5T6X5     348 sdshkllheyamhlsacayvkdtdlsqcif-------nhsqrtlaykankaiernfvmrndflwdyaepgLIHSIQLAVF 420  human
Q5U9X3     352 edemnnsflkeflkl------------------------------------nagnasntvlelmkstnldKIFSIEMAVT 395  zebrafish
Q9PW88     354 eakmnnsfleeflklp-----------------------------------eignaanavqeqiknthldMVFSVQMAVS 398  goldfish
NP_683766  348 sdshkllheyamhlsacayvkdtdlsqcif-------nhsqrtlaykankaiernfvmrndflwdyaepgLIHSIQLAVF 420  human
OCT80319   348 femnrlldqyawllydcpkvkynelshc----------isnyskeslynierersrtlredflsesmqpgFVYSTQLAVT 417  African clawed frog
KTF79147   329 garndfieeykqlrlnc--------------------------------slspstcavddvlqavdlreaYRERVAMYAF 376  common carp
KKF30996   348 ggynhfieeyknlrfnctpecfsdkppsyc------peanilkmksenacnikdpqeqnddylvtaldtnETLSNKIAVW 421  large yellow cro...
OCT80318   347 hatnvfieeykrlrfectdqykeykrcleasph-nctksqslnfksplacstgnislasddyldrnieldGTYSAYLAVT 425  African clawed frog
Q70VB1     348 sdnnkplhefamlfsackhikdgdlsqcis-------nysqatwtydttktiethlfkrndflwhytepgLIHSIQLAVL 420  Norway rat
OCT80315   344 ygatnsfleeyknirfgctkeyrehlecmnslakncsvfdagkeksplackienvslanddylvrnidwsAPYRTFLAVT 423  African clawed frog
Feature 1                                                                                      
Q5T6X5     421 ALGYAIRDLCQArdcqn--pnafqPWELLGVLKNVTFtdgwnSFHFDAHGDLNTGYDVVLWkein-------ghmtVTKM 491  human
Q5U9X3     396 AVANAVAKLCAErqcqd--stalqPWELLRQLRSITFenggeMYKFDANGDINLGYDLFLWegdqs------dehaDDII 467  zebrafish
Q9PW88     399 AIAKAVVELCVErqckt--psaiqPWELLKQLRNVTFekegvMYNFDANGDINLGYDVCLWddde--------sekNDII 468  goldfish
NP_683766  421 ALGYAIRDLCQArdcqn--pnafqPWELLGVLKNVTFtdgwnSFHFDAHGDLNTGYDVVLWkein-------ghmtVTKM 491  human
OCT80319   418 AIAHAIRKICSNrnckd--pdafaPWELLQGLKTVNFtfdgrNIHFDSRGDANTGYDVLMWmeddd------gridITTV 489  African clawed frog
KTF79147   377 AHGLRALLTCNEsvcsg--dtnfpPWQLVESMRSVNFtldgnTYSFDENGDFADGYDLIMWkenn-------derfIEIV 447  common carp
KKF30996   422 AIANALKNLLKCdnssclgeinfqPWKLLKELKKVKFklddqTFFFDDHGDFVSGYDLIMWekdg-------qhrrFQRI 494  large yellow cro...
OCT80318   426 AIAKALNKMLCSngicnp-tttfaPWQLLKELKKIQFydnneNIFFTDDGDVNISYDLLFWytvn-------gsmqFHVV 497  African clawed frog
Q70VB1     421 ALGHAIRDLCQDrdcqk--pnafqPWELLAVLKNVTFtdgknSFHFDAHGDLNTGYEVVLWketn-------glmtVTKM 491  Norway rat
OCT80315   424 AIAQSLHNILCKngkcdk-nidfsPSELLKEIRKVKIpfkseYYSFDVNGDLLSGYDIINWhtfgmypafkavgqyDTIT 502  African clawed frog
Feature 1                      
Q5T6X5     492 AEYdlq-ndvFIIPDQ 506  human
Q5U9X3     468 AEYdpt-kggFHYIHN 482  zebrafish
Q9PW88     469 AEYyps-nssFTFTRK 483  goldfish
NP_683766  492 AEYdlq-ndvFIIPDQ 506  human
OCT80319   490 AEYdsq-kdsFVFKNT 504  African clawed frog
KTF79147   448 GKFllknrdvEILSQF 463  common carp
KKF30996   495 GKYhis--deQIKLDV 508  large yellow croaker
OCT80318   498 GKYeli-nnsVHFNES 512  African clawed frog
Q70VB1     492 AEYdlq-hdvFITTNQ 506  Norway rat
OCT80315   503 SEImld--ehIIFWNN 516  African clawed frog

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