Conserved Protein Domain Family
PBP1_GPC6A_like

?
cd06361: PBP1_GPC6A_like 
Ligand-binding domain of the promiscuous L-alpha-amino acid receptor GPRC6A which is a broad-spectrum amino acid-sensing receptor
This family includes the ligand-binding domain of the promiscuous L-alpha-amino acid receptor GPRC6A which is a broad-spectrum amino acid-sensing receptor, and its fish homolog, the 5.24 chemoreceptor. GPRC6A is a member of the family C of G-protein-coupled receptors that transduce extracellular signals into G-protein activation and ultimately into cellular responses.
Statistics
?
PSSM-Id: 107356
View PSSM: cd06361
Aligned: 6 rows
Threshold Bit Score: 688.146
Threshold Setting Gi: 82079731
Created: 6-Jun-2007
Updated: 17-Jan-2013
Structure
?
Aligned Rows:
 
putativeputative
Feature 1:putative ligand-binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to the Rattus norvegicus mGluR subtype I complexed with glutamate

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                            #                                           
gi 74745292   37 IIGGLFAIHEKMlssedsp----rrpqiqECVGFEISVFLQTLAMIHSIEMInnst--llpgVKLGYEIYDTCtevTVAM 110
gi 118088641  37 IIGGLFAVHSEMlqpeehp----ikpviqNCAGFEIQIFLQTLAMIHAIEMInnst--llsgVTLGYEIYDTCaevTKAM 110
gi 112807234  37 IIGGLFAIHEKMlssedsp----rrpqiqECVGFEISVFLQTLAMIHSIEMInnst--llpgVKLGYEIYDTCtevTVAM 110
gi 81870914   37 MIGGLFAIHEKMlssddhp----rqpqiqKCVGFEISVFLQTLAMIHSIEMInnss--llsgVKLGYEIYDTCtevTAAM 110
gi 82118692   38 IIGGLFPIHEAAeavnftglnsfssfqhpVCNRYYTKGLNQALAMIHAVEMAnqspmlsslnLTLGYRIYDTCsdvTTAL 117
gi 82079731   36 IIGGLFPIHEAVvpvnytgnnsisapehpDCIRFYTKGLNQALAMINAVEMAnkspmlsslnITLGYRIYDTCsdvTTAL 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                   ##                   
gi 74745292  111 AATLRFLSKFNCSREtvefkCDYSSYMPRVKAVIGSGySEITMAVSRMLNLQLMPQVGYESTAeILSDKIRFPSFLRTVP 190
gi 118088641 111 ASALRFLSKSNTSKDivefkCNYSDYVPRIKAVTGASySEVSMAVSRLLALQLIPQVSPASSAeILSDKIRFPSFLRTIP 190
gi 112807234 111 AATLRFLSKFNCSREtvefkCDYSSYMPRVKAVIGSGySEITMAVSRMLNLQLMPQVGYESTAeILSDKIRFPSFLRTVP 190
gi 81870914  111 AATLRFLSKFNCSREtvifqCDYSSYVPRVKAIIGAGySEISMAVSRMLNLQLMPQVSYESTAeILSDKIRFPSFLRTVP 190
gi 82118692  118 WAVQDLTRPYSYCDSq----TNSSQPVQPIMAVIGPSsSEISIAVARELNLLMIPQISYASTAtILSDKSRFPAFMRTVP 193
gi 82079731  116 RAVHDIMRPFSDCESp----EDSSQPVQPIMAVIGTTsSEISIAVARDLNLQMIPQISYASTAtILSDKSRFPAFMRTVP 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 74745292  191 SDFHQIKAMAHLIQksgWNWIGIITTDDDYGRLALNTFIIQAEANnVCIAFKEVLPAFLSDntievrINRTLKKIILEa- 269
gi 118088641 191 SDFHQTRAMAHLICesgWNWIGVIATDDDNGRFALESFGVQAMANsVCIAFKEMLPAYLSDntfhtkVDRAVEKIVKEt- 269
gi 112807234 191 SDFHQIKAMAHLIQksgWNWIGIITTDDDYGRLALNTFIIQAEANnVCIAFKEVLPAFLSDntievrINRTLKKIILEa- 269
gi 81870914  191 SDFYQTKAMAHLIRqsgWNWVGAITTDDDYGRLALNTFAIQAAENnVCIAFKEVLPAFLSDntievrINQTLEKIIAEa- 269
gi 82118692  194 NDEYQTHAMVQLLKdnkWTWVGIIITDGDYGRSAMESFVKHTEREgICVAFKVILPDSLADeqklniHINETVDIIEKnt 273
gi 82079731  192 SDEYQTCAMAKLLKsnkWSWVGIIITDGDYGRSALEGFIQHTETEgICIAFKAILPDSLADqqklntDIENTLNIIENnp 271
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 74745292  270 qVNVIVVFlrqfhVFDLFNKAIEMni--nKMWIASDNWSTatkittiPNVKKIGKVVGFAFrrGNISSFHSFLQNLhllp 347
gi 118088641 270 rVNVIVVFmrqfhVLKLFKKAIERnv--kKIWIASDNWSTavkistmPNIRKLGTVVGFGFknKDLSTFQDFLRNLhdrp 347
gi 112807234 270 qVNVIVVFlrqfhVFDLFNKAIEMni--nKMWIASDNWSTatkittiPNVKKIGKVVGFAFrrGNISSFHSFLQNLhllp 347
gi 81870914  270 qVNVIVVFlrkfhVFNLFNKAIERki--sKIWIASDNWSTaakiitiPNVKKLGKVVGFTFrrGNMSSFHSFLQTLhmyp 347
gi 82118692  274 kVNVVVSFakssqMKLLYEGLRSRnvpknKVWVASDNWSTsknilkdVNLSDIGNILGFTFksGNVTAFLQYLKDLkfgs 353
gi 82079731  272 kVRVVISFakssqMQLLFKGLQSRnisnnMVWVASDNWSTakhilndGSITDIGKVLGFTFksGNFTSFHQYLKNLqfes 351
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                           #            
gi 74745292  348 sdshkllheyamhlsacayvkdtdlsqcifnhsqrtlaykankaiernfvmrndflwdyaepgLIHSIQLAVFALGYAIR 427
gi 118088641 348 tennkflleyimllsvcahldnydfqmc---issqsqydlmqnvenkhqiwrddflnaniepgFIHSTILAVYAIAHAIK 424
gi 112807234 348 sdshkllheyamhlsacayvkdtdlsqcifnhsqrtlaykankaiernfvmrndflwdyaepgLIHSIQLAVFALGYAIR 427
gi 81870914  348 sdnnkplhefamlfsackhikdgdlsqcisnysqatwtydttktiethlfkrndflwhytepgLIHSIQLAVLALGHAIR 427
gi 82118692  354 eakmnnsfleeflklp----------------------------eignaanavqeqiknthldMVFSVQMAVSAIAKAVV 405
gi 82079731  352 edemnnsflkeflkl-----------------------------nagnasntvlelmkstnldKIFSIEMAVTAVANAVA 402
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 74745292  428 DLCQArdcqnpnafqPWELLGVLKNVTFtdgwnSFHFDAHGDLNTGYDVVLWkein-ghmtVTKMAEYdlq--ndvFIIP 504
gi 118088641 425 GQCKDrncknpsafaPWELLEELKKVTIidddkEIKFDSKGDLSSGYDVLLWkevd-grmeITTMAEYdpe--ngyFIFE 501
gi 112807234 428 DLCQArdcqnpnafqPWELLGVLKNVTFtdgwnSFHFDAHGDLNTGYDVVLWkein-ghmtVTKMAEYdlq--ndvFIIP 504
gi 81870914  428 DLCQDrdcqkpnafqPWELLAVLKNVTFtdgknSFHFDAHGDLNTGYEVVLWketn-glmtVTKMAEYdlq--hdvFITT 504
gi 82118692  406 ELCVErqcktpsaiqPWELLKQLRNVTFekegvMYNFDANGDINLGYDVCLWddde--sekNDIIAEYyps--nssFTFT 481
gi 82079731  403 KLCAErqcqdstalqPWELLRQLRSITFenggeMYKFDANGDINLGYDLFLWegdqsdehaDDIIAEYdptkggfhYIHN 482

                 ..
Feature 1          
gi 74745292  505 DQ 506
gi 118088641 502 DE 503
gi 112807234 505 DQ 506
gi 81870914  505 NQ 506
gi 82118692  482 RK 483
gi 82079731  483 DL 484

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap