Conserved Protein Domain Family
PBP1_mGluR

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cd06362: PBP1_mGluR 
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Ligand binding domain of the metabotropic glutamate receptors (mGluR)
Ligand binding domain of the metabotropic glutamate receptors (mGluR), which are members of the family C of G-protein-coupled receptors that transduce extracellular signals into G-protein activation and ultimately into cellular responses. mGluRs bind to glutamate and function as an excitatory neurotransmitter; they are involved in learning, memory, anxiety, and the perception of pain. Eight subtypes of mGluRs have been cloned so far, and are classified into three groups according to their sequence similarities, transduction mechanisms, and pharmacological profiles. Group I is composed of mGlu1R and mGlu5R that both stimulate PLC hydrolysis. Group II includes mGlu2R and mGlu3R, which inhibit adenylyl cyclase, as do mGlu4R, mGlu6R, mGlu7R, and mGlu8R, which form group III.
Statistics
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PSSM-Id: 107357
View PSSM: cd06362
Aligned: 31 rows
Threshold Bit Score: 560.709
Threshold Setting Gi: 72012379
Created: 18-May-2007
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
ligand-bindingdimerization
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand-binding site [chemical binding site]
Evidence:
  • Structure:1EWK; Rattus norvegicus mGuR subtype I complexed with glutamate, contacts calculated at 3.5 A.
    View structure with Cn3D
  • Structure:2E4U; Rattus norvegicus mGluR subtype II complexed with glutamate, contacts calculated at 3.5 A.
    View structure with Cn3D
  • Structure:2E4Z; Rattus norvegicus mGluR subtype III complexed with 2-morpholin-4-ylethanesulfonic acid, contacts calculated at 3.5 A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                        #                                                
1EWK_A         11 GDVIIGALFSVHhqppaekvperkCGEIREQYGIQRVEAMFHTLDKINadp-vllPNITLGSEIRDSCwhsSVALEQSIE 89
gi 2495081     85 GDILIGGVFPVHsksln---gdepCGEIAETRGVHRVEAMLYALDQINsqn-dflRGYKLGALILDSCsnpAYALNQSLD 160
gi 21627691   226 GDVILGGLMMVHsred-----sitCGPIMPQGGIQALEAMLFTIDRINreq--llPNITLGAHILDDC---DKDSYGLEM 295
gi 72008357    34 GDLILGGLFPIHetgp----sglrCSELRETETLHRLEAMAFAIEEINnlt-dilPGVTLGFEIRDTCsdvSMTQIGALK 108
gi 156384916    3 GDILLGGLVPVHsknv-----dlqCGELQERLGIQRLEALLYALDKINaanstllNGITLGLQLYDTCsseTMALDKSLN 77
gi 156402624   76 GDVILGGLFNVHsrstt---tengCGSIDLNPGFQYYAAAVFAIDEINknp-nilPGVKLGARIYDTCrsqTIGGDDAME 151
gi 156405417   99 GDVIIGGLFPVHlknqk---sensCGPISTQPGFQYLAAMLFALELINnss-tllRNITLGASIYDTCqsqTIGADHAKD 174
gi 62297775    43 GDVIIGALFSVHhqppaekvperkCGEIREQYGIQRVEAMFHTLDKINadp-vllPNITLGSEIRDSCwhsSVALEQSIE 121
gi 113679932   52 GDVIIGALFSVHhqpsaervadrkCGDVREQYGIQRVEAMFHTLDRINadq-nllPNITLGCEIRDSCwhsSVALEQSIE 130
gi 46049084    39 GDIIIGALFSVHhqptvdkvherkCGEVREQYGIQRVEAMLHTLDRINldp-tllPNITLGCEIRDSCwhsAVALEQSIE 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                    #                    ###             
1EWK_A         90 FIRdslisirdekdglnrclpdgqtlppgrtkkPIAGVIGPGsSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTlYKYF 169
gi 2495081    161 FVRdmigsseasdyvcl--dgsdpnlkkqsqkkNVAAVVGGSySSVSVQLANLLRLFRIAQVSPASTNADLSDKNrFEYF 238
gi 21627691   296 AVRk-----------------------------VISGVVGAAsSVTSIQVANLLRLFRIPQVSYFSTSPELSNKQrFEYF 346
gi 72008357   109 FLPsdftrgatcpm--------stnastlleasPIIGVVGTEmSKTTMSAAQLLGLNHVPVVSYYATSDDLSDTIqYPYF 180
gi 156384916   78 FIYsqlks--------------------estssRVVGIIGAAySSVSIQIARLSRLFEIPQISYDSTSFELSDKKrFGFF 137
gi 156402624  152 IIKytlldr-------------------tnstpPLAGVIGPFrSDVAVAVANLLGVFNIPQVSFGATTTKLSNKQiYKYF 212
gi 156405417  175 IIKesll----------------------tnnkLLKGVVGPLvSDVSIATVQLLRVFGLPQVSFGSTSPDLSNKDlYGSF 232
gi 62297775   122 FIRdslisirdekdginrclpdgqslppgrtkkPIAGVIGPGsSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTlYKYF 201
gi 113679932  131 FIRdslisirddkdgskwcidgtpsnqpppskkPIAGVIGPGsSSVAIQVQNLLQLFNIPQIAYSATSIDLSDKTlFKYF 210
gi 46049084   118 FIRdslisseeeegmvr---cvdgssssfhskkPIVGVIGPGsSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTlFKYF 194
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                           #                                             
1EWK_A        170 LRVVPSDTLQARAMLDIVKrynWTYVSAVHTEGNYGESGMDAFKELAAQEgLCIAHSDKIysna---geksFDRLLRKLR 246
gi 2495081    239 ARTVPSDDYQAMAMVEIAVkfkWSYVSLVYSADEYGELGADAFKKEARKKgICIALEERIqnkke-sftesINNLVQKLQ 317
gi 21627691   347 SRTIPSDHYQVKAMVEIVKrmgWSYVSIIYEESNYGIKAFEELEELLARHnICIAIKEKLvkdsgvaediaYDNIVQKLL 426
gi 72008357   181 LRVVPPDRLQVQAMLELIRtyeWSYIYLLHSDDSYGTNAFQEIVRVADEIgVCLAETWEIgsql---teedFDNIIMNMQ 257
gi 156384916  138 SRTVPHDNFQAKALVDVLKyfnWTYVSVVYSDDSYGILGVDALRSAATRAgICMASSHKVrssg---hestYLLVVDSIL 214
gi 156402624  213 FRTVPPNSFQGRALVDVVRyfkWSYVMTVHSHGDYGEPGMDEVKSAAAKHgVCIAGDYKLppfp---keedFEATIKSLL 289
gi 156405417  233 FRTVPPDSFQAEALVDILEhhgWNYIITINSAGNYGENGMSAIIKITEKRdICIAATFTVppls---tdahYERIIREIA 309
gi 62297775   202 LRVVPSDTLQARAMLDIVKrynWTYVSAVHTEGNYGESGMDAFKELAAQEgLCIAHSDKIysna---geksFDRLLRKLR 278
gi 113679932  211 LRVVPSDTLQARAMLDIVKhynWTYVSAVHTEGNYGESGMEAFKELAAEEgLCIAHSDKIysna---gekhFDRLLKKLR 287
gi 46049084   195 MRVVPSDAQQARAMVDIVKrynWTYVSAVHTEGNYGESGMEAFKDMAAKEgICIAHSYKIysna---geqsFDKLLRKLR 271
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                         #                               
1EWK_A        247 ERlpk----arVVVCFcegmtVRGLLSAMRRLgvv-----geFSLIGSDGWAdrdev--iegyEVEANGGITIKLqspeV 315
gi 2495081    318 PEknv---gatVVVLFvgteyIPDILRYTAERmkltsgakkrIIWLASESWDrnndkytagdnRLAAQGAIVLMLasqkV 394
gi 21627691   427 TKpr-----arGAIIFgsdqeVRQVMRAVRRAnat-----gsFSWIGSDGWSarnlv--sddyEPEVEGTLSVQPqanpV 494
gi 72008357   258 MRsq-----akVVILFinvveANSFFAALRRSgav-----gdYQILGSDGWGmsige-ietlnRPAALGSLKTHLfsahV 326
gi 156384916  215 SEpl-----arTVIVFaqvhqIRGLLHAVQVRnaa-----dqLQFVGSDAWGnvvw---lkdlQSVALNTITVSPksvrL 281
gi 156402624  290 DLskkhsdtvhVVVMFciqrdNTGLVRAAKKLlne----nnrFIFVASNSWGerhpv--tnnnEEGGEGALTLNFidgnV 363
gi 156405417  310 QArfd---avnIIVVFttqtdSAGLLSAAARLga------trFTWLGSNGWSnrmtv--tignEMVANGSITVNHmdgqV 378
gi 62297775   279 ERlpk----arVVVCFcegmtVRGLLSAMRRLgvv-----geFSLIGSDGWAdrdev--iegyEVEANGGITIKLqspeV 347
gi 113679932  288 ERlpk----arVVVCFcegmtVRSLLMAMRRRgvs-----geFQLIGSDGWAdrdev--vegyEQEADGGITMKLqteeV 356
gi 46049084   272 SHlpk----arVVACFcegmtVRGLLMAMRRLgla-----geFLLLGSDGWAdrydv--tdgyQREAVGGITIKLqspdV 340
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                          #              
1EWK_A        316 RSFDDYFLKlrldt--ntrnPWFPEFWQhrfqcrlpghllenpnfk--kvctgnesleenyvqdsKMGFVINAIYAMAHG 391
gi 2495081    395 PSFEEYFMSlhpgteafernKWLRELWQvkykcefdtppgstas-----rcedikqstegfnaddKVQFVIDAVYAIAHG 469
gi 21627691   495 RGFEEYFLSltven--nqrnPWFVEFWEdhfqcrypgststpynnytkqcttkerlsrqntdfedQLQFVSDAVMAFAYA 572
gi 72008357   327 QNFEDHFLGltptk--shdnPWFQEYWNssrncsfikhga-------------sclsstgfsagsAVSLVLDAVSTLALG 391
gi 156384916  282 KGFEEYFTSlspin--nsrnPWFQEYWEhhfncslnetlgkyptk----cndslklslgnsdidmRIASAIDAVYAFAHA 355
gi 156402624  364 KRFKDHLLSltpl---ddnsTWFHEFWQismncklsfakwqfntt----kecrlnemlprdfgiaPVRVSINAVYAAAHA 436
gi 156405417  379 AGFEEFFSSmnpin--nqniPWIDEFWEnwfkcdlpggkptfy-------knctedlvlpkmevaPVRVVINAVYAFAHA 449
gi 62297775   348 RSFDDYFLKlrldt--ntrnPWFPEFWQhrfqcrlpghllenpnfk--rictgnesleenyvqdsKMGFVINAIYAMAHG 423
gi 113679932  357 QSFNDYFLKlrldt--nkrnPWFAEFWQyrfqcripghpqenhnyq--kictgneslkdnyvqdsKMGFVINAIYAMAHG 432
gi 46049084   341 KWFDDYYLElrpet--nhrnPWFQEFWQhrfqcrlegfpqenpkyn--ktctsqmtlrtqhvqdsKMGFVINAIYSMAYG 416
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
1EWK_A        392 LQNMHHALCpghvglcdamkpidgrk------------------------------lldflikssfvgvsgeEVWFDEKG 441
gi 2495081    470 LQSMKQAICpddaienhwisryskqpeichamqnidgsdfyqnyllkvnftgktisifssfrlspfsdivgkRFRFSPQG 549
gi 21627691   573 LRDMHRDLCgggpslceamkptkgad------------------------------llkylrkvefeglsgdEFRFDGNG 622
gi 72008357   392 LSEMHKDLChgqsgicpamtpfdsa-------------------------------llfdymtnlsfegqsgFVTFDSGG 440
gi 156384916  356 LEAMHADLCrytvgvcpamenisgse------------------------------llgyirnasfvgatgeKVHFDANG 405
gi 156402624  437 LHNMYTNLCpkqsgmcdefrnlkren-----------------------------ylkflrnvtfpdaasnvTVRFNRNG 487
gi 156405417  450 LDDMQRALCpgkvglceamiadssgkt----------------------------lidflrnvtfpdasygwPVRFNKNQ 501
gi 62297775   424 LQNMHHALCpghvglcdamkpidgsk------------------------------lldflikssfigvsgeEVWFDEKG 473
gi 113679932  433 LHDMHREMCpehsglceamdpidgsk------------------------------lldyllktsfsgvsgeEIYFDVNG 482
gi 46049084   417 LHNMQLSLCpgyvglcdamkpidgrk------------------------------lleslmktnftgvsgdMILFDENG 466
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
Feature 1                                                        
1EWK_A        442 DAPGRYDIMNLqytea-----------nrydYVHVGTWhegVLNIDD 477
gi 2495081    550 DGPASYTILTYkpksmdkkrrmtddesspsdYVEIGHWs--ENNLTI 594
gi 21627691   623 DGPARYNIIHFkqsqa-----------gqyhWVKVGEYtegELRLNM 658
gi 72008357   441 DAIGRYVIDNIqven------------inyeLVKVGLWs--AIQENL 473
gi 156384916  406 DVEGIYDVMRFekss------------gtyrNVIIGTWk-dKLRMRN 439
gi 156402624  488 EVDGNYSIVNFrkvd------------gkytYLKVGSWg-gVLKPDD 521
gi 156405417  502 EMDGNYSIMNFqyqn------------gkwiYENVGSWswgDESDNV 536
gi 62297775   474 DAPGRYDIMNLqytea-----------nrydYVHVGTWhegVLNIDD 509
gi 113679932  483 DSPGRYDIMNLqyvee----------igrfdYINVGSWhegLLSISD 519
gi 46049084   467 DSPGRYEIMNFkkmgk-----------dyfdYINVGSWdngELKMDD 502

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