Conserved Protein Domain Family
PBP1_Taste_receptor

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cd06363: PBP1_Taste_receptor 
Ligand-binding domain of the T1R taste receptor
Ligand-binding domain of the T1R taste receptor. The T1R is a member of the family C receptors within the G-protein coupled receptor superfamily, which also includes the metabotropic glutamate receptors, GABAb receptors, the calcium-sensing receptor (CaSR), the V2R pheromone receptors, and a small group of uncharacterized orphan receptors.
Statistics
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PSSM-Id: 107358
View PSSM: cd06363
Aligned: 14 rows
Threshold Bit Score: 561.921
Threshold Setting Gi: 88900455
Created: 29-May-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putativeputative
Feature 1:putative ligand-binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to the Rattus norvegicus mGluR subtype I structure complexed with glutamate

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                               #                                        
gi 88900455   38 FKSPGDILIGGLFpinqltselsqrv-kpddlqcdsistYGLSLSLVMKFTVDEINsk---khILPGITLGFESYDTCmq 113
gi 57013075   32 FTLPGDYLLAGLFplhsgclqvrhrpevtlcdrscsfneHGYHLFQAMRLGVEEINns---taLLPNITLGYQLYDVCs- 107
gi 124377982  22 LHLQGDYILSGWFalhnsdstipptp-ylndckkgltnkHGYHLVQAFRYAVDEINngtqdkqLLPGVTLGYRTYDICs- 99
gi 118344624  32 FNLPGDIKLGGLFplnrltsnlsqrt-epdqiscdrintYGLGMAIAMKYTVDEINan---qiLLPGIQLGYEIYDTClq 107
gi 118101034  26 FRRPGDYIIGGLFpfgmdtinltars-eptlivcerlfvDGLIWALGMKFAIDEINns---tsLLPGVELGYDIYDTCfe 101
gi 62299063   29 LRMKGDYVLGGLFplgeaeeaglrsrtrpsspvctrfssNGLLWALAMKMAVEEINnk---sdLLPGLRLGYDLFDTCse 105
gi 124358889  25 FNLQGDYLLGGLFdihyasvahyrnipeavicssnpftlSSYRRFQMMRFSIEEINns---tsLLPNVTLGYEIFDHCs- 100
gi 124358885  28 FHLRGDYLIGGLFnihyvaaanfqrp-qaidcssklfilPNYRRFQLMRFSVEEINns---ssLLPNISLGYQMFDHCs- 102
gi 149440977  32 FSLPGDHILGGLFsihsslesrskpe-vtscdgverfnsDGYHLFQAMRFTIEEINns---tsLLPNTTLGYELYDVCt- 106
gi 124358887  22 FNLKGDFIIGGLFgihdasdtvhhdrpeaincsshqfsaSNYRRFQLMRFSVEEINns---tsLLPNVSLGYEMFDHCs- 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                      ##                
gi 88900455  114 pAVIMKPVLQLLTqestdeldiyCNYTNYKPRVMAIIGPDssdvvpdAGKLIGFFLMPMISYGATSDEFSnkqtYPSFMR 193
gi 57013075  108 dSANVYATLRVLSlpgqhhielqGDLLHYSPTVLAVIGPDstnraatTAALLSPFLVPMISYAASSETLSvkrqYPSFLR 187
gi 124377982 100 lPASNLATLDLLAq--------qLHPSAVDSRAVAIIGPDsssyaftPAAALGVFLVPQISYEATNELLSnkllYPSFFR 171
gi 118344624 108 sAIIVRPTLSLLSakhdntfsvqCNYTNYETSISAVIGPNnsemvsvIGKLLGFFLMPQISYGATSEKFSdtalYPSFFR 187
gi 118101034 102 pLAALQPSLLFVTqngttgigiaCNYTDYQPRVTAVIGPHksdlcllTAKLFSFFLIPQVSYGASSEKLSnkelYPSFYR 181
gi 62299063  106 pVVAMKPSLMFLAkagsrdiaayCNYTQYQPRVLAVIGPHsselamvTGKFFSFFLMPQVSYGASMELLSaretFPSFFR 185
gi 124358889 101 dTKNFPGIFSLMSvvgs---iqpWKESVNFSKVIAVVGTYtstatltVAPLFMKDLVPLISYGAASSVFSrkknFPSFLR 177
gi 124358885 103 dIHSFPGIFKLLSvndl--irpwEDASTGLPNAIGVVGPFtsthalsIAPIFMTNLFPMVSYGCSGSVFSkknlYPSFLR 180
gi 149440977 107 eSSNLFATLSLLAepqgrrievqRDLTRSSPKVVAVIGPDntnyalaSAAILSAFMVPQISYEASSVTFSqkrdFPSFLR 186
gi 124358887  98 dALSFPGVFRLMSvngs--iqpwAEPNDKVYKVIAVIGPFtsteamtVAPFFMPDLIPVVSYGSSSSIFSskvkYPSFLR 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 88900455  194 TVASDQWQVVAMIQLLKqFGWNWVSVIGSDEeYGQMGQQQFSSMANDEsICVAYQGLIpvysd---pgptIQDMLNRIVD 270
gi 57013075  188 TIPNDKYQVETMVLLLQkFGWTWISLVGSSDdYGQLGVQALENQATGQgICIAFKDIMpfsaq--vgderMQCLMRHLAQ 265
gi 124377982 172 TIPSDKNQVNAMIQVLVkFNWTWIALLGSDNsYGIQGMQSLSEQAPLNnICIAYQAQIpavtd--stkkyMQDMVKNILK 249
gi 118344624 188 TVPSDKWQVEAMVLLLEeFNWNWVAVVGSDEeYGQRGVQDFSKLAANKsICVAYQGLIpvytd---pepmVKTILSNINS 264
gi 118101034 182 TVPSDKNLVEAVVLLLDeFGWNWIATIGSDDeYGRGAQELFLSTIGNSsICIAYEGLIpsdltdpraekqLEETIQYINK 261
gi 62299063  186 TVPSDRVQLTAAAELLQeFGWNWVAALGSDDeYGRQGLSIFSALAAARgICIAHEGLVplpraddsrlgkVQDVLHQVNQ 265
gi 124358889 178 TVHPNKDVIKMIFEILQrFKWTWVTFLYADDdYGRDGYDLFVKMIRNTeICLGYSKGLntd-------tdYPKMFKQIID 250
gi 124358885 181 TVHSNKDVINAIVGIILnFNWRWVAFLYSDDdFGKDGLEQFKNKIEDSeICLAFYKAIniy-------tdYPQVFKQIEE 253
gi 149440977 187 TIPSDEHQVEALVHLLGeFGWHWFSLVGSDNeYGWQGAQSLRALATQRgMCIAHQGTVplraq--pgdrdVRALVAKVNR 264
gi 124358887 176 TGNPNKDVIDVIVTMVQhFNWSWVAFLNSDDaYANDGLELFMRKIKTTeICLAYTKSVnqn-------tdYSQIFKNIED 248
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 88900455  271 AkvgVVVVFsipipAKAFFTEVIKRni-tAVWVASTAWslndgvstLPGISSIGTVLAFAditrpLDLFTPYIRElftki 349
gi 57013075  266 AgatVVVVFssrqlARVFFESVVLTnltgKVWVASEAWalsrhitgVPGIQRIGMVLGVAiqkraVPGLKAFEEAyarad 345
gi 124377982 250 TkvnTIVVFankrrAAGFFPFVIAQnvtgKVWIGTEDWsvastvssIPGISMIGTVIGVAvkyteFDGFDNYERLsvpgl 329
gi 118344624 265 TkarVVIVFslsnqAEIFFKEVIRMkl-kGVWIGSTSWtindavtsLPDIQTGWTILGFVeqtqsVDLLRAYTYAllnkl 343
gi 118101034 262 TnvnIIVLFafrqpAQALLKQSIKMrlskKVWIGTEAWllsdiaasIPNIQNIGTVLGFImkastVPGFQKYVANllssv 341
gi 62299063  266 SsvqVVLLFasvhaAHALFNYSISSrlspKVWVASEAWltsdlvmgLPGMAQMGTVLGFLqrgaqLHEFPQYVKThlala 345
gi 124358889 251 FrvnVIIVFtaewtAEAVINSAIQQnvtnKVWIAADAWslhkelpkKTGIRNIGTVLGVAepkttIPGFSDFIYSfkaqn 330
gi 124358885 254 QnikVIVVFapkvyAEAVVESAVQLnvtnKVWIADDGWslnkklpsMNGIQNIGTVLGVAqpvvtIPGFTDFIHSaisqt 333
gi 149440977 265 Ts--VVVVFssrrlAQVFFETVVQErlreKVWLASEDWslsrsitrLPGVRGIGTVIGVAvqqgrVPGIGAFEAAyvrae 342
gi 124358887 249 QrinVIIVFasevaAEALIESAVQLnvtnKVWIAADTWslnkrllkMNGIRNIGTVLGLSqpaltIAGFSEFITSfetqs 328
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                   #                                    
gi 88900455  350 egmaipqqpdadispldn--pcprcsyvsqanvsmvevdlvqrSAFSVYAAVYCAAYALHDLLGCnatsctrnpkrdnvy 427
gi 57013075  346 kkaprpchkgswcssnq----lcrecqafmahtmpklkafsmsSAYNAYRAVYAVAHGLHQLLGCasgacs----rgrvy 417
gi 124377982 330 knpgqfnlsvpcmqn---------tnlydiaingfslsqyditSSFNVYKAVYAVAHALHNVLDCdsglcq----kydvq 396
gi 118344624 344 seerahtrssaqnsnypsn-pcpqcwnlspanislvtdlviqrKAFSVYAAIYSVAQALHNFLQCnstackn-tsevkiy 421
gi 118101034 342 qqdefcqksrgfyrhvssdtlgtqcqqcdhislndisstlshsQIQPVYIAVYSVAYALHRALGCthqgcp----rasir 417
gi 62299063  346 tdpafcsalgereqgleedvvgqrcpqcdcitlqnvsaglnhhQTFSVYAAVYSVAQALHNTLQCnasgcp---aqdpvk 422
gi 124358889 331 qcenpeqdpfcnq------------rcncssvsaediitadpsFNFPVYSAVYAVAHALHAVLQCgagscn---ksikvy 395
gi 124358885 334 dggdteqkmfcnq------------kcncsnlsvktllnadpsFSFPVYAAVYAIAHALHNTLRCgsdrch---knitvh 398
gi 149440977 343 kgparpcqesaclagnq----icsrcrsfsrddrpelepfamsVAYNVYAAVYAVAHGLHQLLGCssgtca----rgpvr 414
gi 124358887 329 rytenmpqkfcnq------------vsnwdtgrakdildadpsFSYPVYSAVYAIAHALHKVLQCgtagcn----niivy 392
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                              
gi 88900455  428 PWQLLRKLQKLSLDLegvNIQFDDEGNPNFGYDFMQWifndttvtFDVIGYFy----qNLTIESNAIKWH 493
gi 57013075  418 PWQLLEQIHKVHFLLhkdTVAFNDNRDPLSSYNIIAWdwngpkwtFTVLGSStws-pvQLNINETKIQWH 486
gi 124377982 397 PWQVYEQLRQVRFSIrnaSFYFDKNGDPPTGYDIVTWewtnglwsFKVVGNYspg-anDLHLDDSQIDWS 465
gi 118344624 422 PWKLLKTLRHTKVDIngtMLEFDSNGNPNVGYNLIELiwknstleFVEVGSFn----kILNINVSLFKWH 487
gi 118101034 418 SWQLLHFMNTVPFTVngqSFRFDESHGTNSGYKLIFWhwengsltHLPVGDYq----eSLYLNKSLIQFH 483
gi 62299063  423 PWQLLENMYNLTFHVgglPLRFDSSGNVDMEYDLKLWvwqgsvprLHDVGRFn----gSLRTERLKIRWH 488
gi 124358889 396 PHMVLHELRRSSFTFlnqTVQFDDNGDPKFGSVAIVFwns--sgnAEEVGFFsfyptfKFFINSSKIKWH 463
gi 124358885 399 PHMILEELKKSNFTLlnqTVQFDENGDPKFGSLSVVFwns--sgnAEEVGSYhfqssiHLSINKTKIKWF 466
gi 149440977 415 PQQLLEKIWQVNFSLegnPVHFDPNGDPARGYDIVVWgwngpswtFSIIGSArwh-piRLTVDRALIRWH 483
gi 124358887 393 PNMVLAEIQKSNFTLlnrTVLFDENGVLRSGLFSLVFwns--sgdAEEVGLYsfyptvTFFINISKINWH 460

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