Conserved Protein Domain Family
PBP1_Pheromone_receptor

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cd06365: PBP1_Pheromone_receptor 
Ligand-binding domain of the V2R phermone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily
Ligand-binding domain of the V2R phermone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily, which also includes the metabotropic glutamate receptor, the GABAb receptor, the calcium-sensing receptor (CaSR), the T1R taste receptor, and a small group of uncharacterized orphan receptors.
Statistics
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PSSM-Id: 107360
View PSSM: cd06365
Aligned: 29 rows
Threshold Bit Score: 499.075
Threshold Setting Gi: 46091167
Created: 29-May-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putativeputative
Feature 1:putative ligand-binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to the Rattus norvegicus mGluR subtype I structure complexed with glutamate.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                 #                                       
gi 35215313    38 GTVVIGAFFpilhnslvrtttdwk--yfpmdsdnyfgmsgRNYQLVLAMLFAINEINLNSHILPNTSLGLEIYNLPaiGR 115
gi 156139112   41 GDLVIGGFFplylmavksftgae----hpqkacnphqwlhKNYQQVLALMFAVEEINRDSSLLPNTTLGFHIYNSYhsDA 116
gi 126344777   29 GDLVVGGFFpliknkmtkfgywkmfwihpkynmkdyrwlqKHYYQVLALMFAVEEVNRNPNLLPNRTLGFHIYNAYhnDD 108
gi 156139096   39 GDLILGGFFplfmykfsqyttwkmfqrhpqyilkgylrlpKHYYQVLALMFAVEEINKNPNLLPNVTLGFHIYNVYhnDE 118
gi 153792665    9 GDLVIGGFLplyalrvnkvtraadfmrrpnedcrsyqwlhKNFQQAMTIRFAVEEINRDPVLLPNVSLGFQVYNAYhsDE 88
gi 149470129  151 GDLVITGMLslqtlttfpdpifqs--vskhemenydywvhKDFQHFLALLFAVEEINKDPSLLPNVSLGFHVHEIYhhAN 228
gi 149638189   12 GDLVIGGLLalnvfegnlpsfkk----hpfwfdkgfarvpKHNQHVLALVFAVEQINKDPSLLPNFSLGFHLYDTLfrER 87
gi 149573272   43 GDVVIGGLFsldvilsnwgesenf-keeppdiddvteyftKHYQHLMALVFAVEEINKDPNLLPNISLGFHLFNVHflGL 121
gi 110288009   37 ADFVIGGLFslrvtdgdtfisrsgvedtshiaeyvfadliKYYQHILAMVFAIEKINKDPNILFNKSLGFFLFNVNfiEM 116
gi 148667312  548 WLGTYPPFPdvdmhsefgqiilwy-negstlafycvlgylGFLASLSLFIAFLKKINKDPNILFNMSLGFYLFNVDfiVM 626
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                       ##                
gi 35215313   116 NIFRTVFSWLtglssviPNYTCrk--esNSAATLTGVswkt---setIWTILDLYKFPQLTFGPFDpvqidrnqFQSLYQ 190
gi 156139112  117 RTLESSLRWLsgqgqtiPNYSCer--qdKSLAVIGGAtsal---svqMGTLLELYRFPQVSYGPFDtalsdkdqFPSLYQ 191
gi 126344777  109 KILESSLMWLsgqaqtiPNYNCer--qaKSVVVIGGAnsal---tvsMGTLLELYKFPQISYGLFDpllndpaqFPSVYQ 183
gi 156139096  119 GTLESSLMWLsgkgptiPNYNCer--qdNSVVVIGGGtsem---tvsMGTLLELYKFPQVTYGLFDpllsdpvqFPSVYQ 193
gi 153792665   89 RTLESSLQWLtgesqpvPNYSCre--qdKIVAIIGGAtsalsvqmgtLLELYNFPQVGDLSFGPFDliltdkvqFPSLYQ 166
gi 149470129  229 RAMEGALMGLsgveqtvPNYSCgk--qeKSMAVIGGAtsal---siaMATILGLYRLPQITYGPFDpvlsdkirFPSLYQ 303
gi 149638189   88 LAVEQSLMLLsgpgrtvPNYSCee--rgKLVAVIGGIkstl---siaMANVLGFHKFPQITYGPFDgtlrdsgqFPSLYQ 162
gi 149573272  122 IAAESSMSLLsgragwvPNYNCeperwdKLLAVIGGMstav---smtSSWLLGLHKLPQICYGPEDptlrdkaqFPSLYQ 198
gi 110288009  117 KAAEGSMALLsgesppiPNYSCrpektdKLVAVIGGIstsi---siqISRVLSLYNVPQISYAPFDqilgtrvqLQSPYQ 193
gi 148667312  627 KATESSMVLFsgerppiPNYSCrpektnKLVAVIGGYsiai---taeISQVLSLYNVPQISYAPFDqslasrvqLQTPYQ 703
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 35215313   191 VAPKDTALLSGIASLMLHFNWNWVGLLIPDDqrGAQFLSDFRKELDKTkICIAFVKTVLYLGetllrliSQDHIHIIESS 270
gi 156139112  192 MAPQDSSLHLGIVQMLLHFGWTWVGLVVPDDmrGEKFLSDMREEMRRNkACVAFIEKIPVSErcheesqVAFMPRIMASS 271
gi 126344777  184 MATSDTSLSLGMVRLMVHFEWTWVGLVTSDDaiGDKFLRDMKEEMVRNyICVAITQKISIGQsmdidthRLFLWKIFKSR 263
gi 156139096  194 MAPRDTSLPLAMVRLMLYFKWTWVGLVASDDsrSEKFLRDLQEEMVRNdVCVAFMLKFATGDkmsipsfDNFLQKIYSST 273
gi 153792665  167 MAPKDYSLQQGVARLLAYFKWTWVGLVTTDDlrGEEFLREMTGRMEKYgICAAFTEKIPVSEriheeskVNFMPRIMESS 246
gi 149470129  304 VAPRISSLPRMIVQLMVHFGWTWVGLVVSDDmrGESFLSDVTGEMVRNgVCAAFTEKIPSGRfst-ykvQHFYARIMASS 382
gi 149638189  163 MAPRDTAQQRGIVRLLVHFGWTWVSLVISNNvqGETFARDLMGEMDRHgVCVAFTEQIPETKyygtweaRLFHHKMNTIL 242
gi 149573272  199 ISTSSPNLPSGMIRLMKHFHWVWIGILVTDDirGETFATVLTEEMAKNgICVAYVKRVNNYFsksvsslEYNHREITTSS 278
gi 110288009  194 FSMHTAALYQGIVQLLLYFTWIWVGLVVPDDmrGELYLRDITKEMISHgICFAFAEKVTEYSsmdtvnwKHFMERLTLTP 273
gi 148667312  704 FPVHTTALYQGIIQLLLYFTWVWVGLVVPDDsrGELFIMEFIEEMINHrLCVAFAIRSPQFPfenqgkwEIFCEKIPLTR 783
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 35215313   271 tadVIVIYGPtsiLLTLIENTYRTyn--kkKIWVMSTKWFcpn--lelYNMLELTHGALIFSPhykeIVGFKKFMLEATP 346
gi 156139112  272 a-kVIIIHGDtdsLMILRYSQPPSis--lwKIWIITSHWDvtm--rphNHDSDTFLGALIFSHqtseIPGFKSFLKAVTP 346
gi 126344777  264 v-nVIVIYGDidsLLSVKFREEPYfl--pkILWITTRDSDitk--kpgSVYFDNFHGALIFSTktsqMPGFQHFLKTINP 338
gi 156139096  274 a-kIIVIYIDsdsFQSQVFDSDAHkhilihKMWITNSYWNiar--spsRIYSNNFHGALIFSDqtskTFGFKPFLKPINP 350
gi 153792665  247 a-rAVVIHGDtdsLMVLRHSQIPFip--myKIWITTSHWDitm--rpkYVDNYNFYGALTFTYltseVPGFKSFLKTVHP 321
gi 149470129  383 t-nVIAAYGDaefLNLLRAVIEWFgl--skMVLITTYHWDftls-mmhEPNNNHFHGTLTMASfakeVPGFRDFLRTIRP 458
gi 149638189  243 v-nVVIVHGDidsLIMFKWVIGWAei--wgKVWITTAHWDisvs-nayNTYQNSFCGSLSFSIhtdeITGFEDFVREASP 318
gi 149573272  279 a-gVVADYGDtfsLLAVVYRMDLNpi--ygKVWVTTSDWDlta--ntyMKDNTFFQGSLLFSLhrkeIPGFRDFEQILNP 353
gi 110288009  274 ---VIITVGDthsLLRIVYFVIFYnl--sgNVWITTSDWYittlpfeqNLIYTHFGGGLSFSFhmdeILGFKDFLRSVQP 348
gi 148667312  784 ---VIIAVGDtydTIWIFYIITLYip--ygKIWITNSDWFttlp-sqlNFIYKYFSGGLLVLHkmdeILGFKDFLRNVQP 857
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                               #                         
gi 35215313   347 IKYpeDIFLHLLWYWHFNCsflhseckifenc--lqnaslellpgniFTMTMTeESYNVYNAVYAVAHSLHeetlsqiqf 424
gi 156139112  347 AKYpgDIFLKSFWVSAFECpdepdkleredcp---lnaslemlplhyFDMTMLsLSYYVYSAVYAVAWALHemletrpev 423
gi 126344777  339 LNYpdDIFLEQFWVTTFGCtsnhrkgdgsvcs---qnasfdtlslsyLDEIMSyQSYTVYNAVYAVAWALHemllvrsei 415
gi 156139096  351 AKYpeDILHQNLWDSVFKCtsnkkkgvgdvcs---tnvsldeshwsyLDMTMSdQSYTVYKAVYAVAWALHemflrrsem 427
gi 153792665  322 SKDpkDTVLRDFWFSAFQCqsksknldleqct---pnetleslpiylFDTTMSgLSYTIYNAVYAVAWALHeellrkset 398
gi 149470129  459 AKYpdSIILKKFWESAFDCalsfseiygrkcs---enaslemlpmhyFSLMMSaPSYSVYNAVYAVAHGFQelllsrsdv 535
gi 149638189  319 SKYpnDVFLQQFWEAEQGCflslrqmgrkrtgvcmgnesfdrlpqfdLDLQLSgLKYTLYSAVYAVARVLHemllsrtea 398
gi 149573272  354 RKYplDAFLLKFWQWAFECqyldsflsmtcd----fndtlenrpldlWDMSLSaQSYSVYSAVYAIAHALHqeiwaeriw 429
gi 110288009  349 RKYphDIFIRHVWSSLFGCphyyqhrlwdlsqc-epngslstrplhaWDMNTSpYSYKVYAAVYAIAQALHeelslrveg 427
gi 148667312  858 RKYphNIFIQDMWSILFECpyfyrqkvrvlsqc-epngslstqplhvWDMNTSpSSYKVHAAVYAIAQALReelsvrveg 936
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 35215313   425 qpqanidrtllfpwqlhpFLKKIQVknsvgdHVVLDWkRKADPEYDITNIwnfptglslLVKVGTFvpsapkgeQLSMSE 504
gi 156139112  424 eserderslapqnwqlhsSLRNTDFnntaenLVVLDDeKNPVAKYDIMNFalksnydevLVKVGQFvpqdplghDLTICE 503
gi 126344777  416 etkihggnqiihpwklhsFLKNIQFnnsagnQVVLEKkRKSMTNYDILNYvtfpndtdvLVKVGEFipqtppvqDFTIQE 495
gi 156139096  428 esniqedtwatyprklhsFLKNIQFn-----NSDGKQrQNSMANYDILNHvtfanktevLVKVGEFihqaplgqDFTIHE 502
gi 153792665  399 apeeagesgvphpwqlhsFLKDIQFhnsagdQVFMDEkRRSEAQYDIRNYvtslndtefLVKVGQFlpntqpgqDFIMHE 478
gi 149470129  536 kswgnedrlvpppwqfheFLRNVQFdnpagqLVILDEnSRSSAKFDILNFvifpngtgeFVKVGEVdpqatpnqDVSVNE 615
gi 149638189  399 evsetgdavifpprqlysFLRRPKLkitaggEWNFDRnNPSVVSYDILNFiqvgfenftRVKVGEFnpqsflgnDLTINE 478
gi 149573272  430 r--------hqemvqlhqFLKNTLShtgtgeQIHLVDpSWVTTKFDILNYqilengskgYVKVGEFmplapagqDFAISD 501
gi 110288009  428 dssnkcllqaplpwklhpFLQKGQLgrs-tnEENTVNkEVSAIKLDIFNYqslqsgteaHVKVGEFvfdshsvqHLSLND 506
gi 148667312  937 dsfdkvllwapvpwklhpFLQNGQFvrs-ssEENIVNkEGSATKLDIFNYqslmsgtkaHVKVGEFvfkshsvqHLSLNE 1015

                  ....*
Feature 1              
gi 35215313   505 YMISW 509
gi 156139112  504 KNIYN 508
gi 126344777  496 KAIVW 500
gi 156139096  503 KAMVW 507
gi 153792665  479 EDINW 483
gi 149470129  616 AMIVW 620
gi 149638189  479 EAIVW 483
gi 149573272  502 EKIMW 506
gi 110288009  507 KIITW 511
gi 148667312 1016 ELISW 1020

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