Conserved Protein Domain Family
PBP1_pheromone_receptor
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cd06365: PBP1_pheromone_receptor 
Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily
Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily, which also includes the metabotropic glutamate receptor, the GABAb receptor, the calcium-sensing receptor (CaSR), the T1R taste receptor, and a small group of uncharacterized orphan receptors.
Links
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Statistics
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PSSM-Id: 380588
Aligned: 42 rows
Threshold Bit Score: 460.572
Created: 29-May-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative ligandputative dimer
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to the Rattus norvegicus mGluR subtype 1 structure complexed with glutamate.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                        #                                            
NP_787950  41 VIGAFFPilhnslvrtttdwkyfpmdsdnyfgmsgRNYQLVLAMLFAINEINLNSHILPNTSLGLEIYNLPa-iGRNIFR 119 house mouse
KFO36455   39 VLGGSFSilhfhsvaqldfv--vppsglpasrvsrWGYRVAQCFVFAVEEINRNPHLLPNLTLGFSIRNSGd-sVHGALH 115 Fukomys damarensis
OCT70724   27 VIGGLVPvhlrpdnnkvdft--kkpdspkcdkfymLRYLEVLAMVYAINEINNDPKLLPNITLGFRICDSCy-kESQAME 103 African clawed frog
OCT85713   28 IIGGLIPvhektvkqtitfk--qrppericekfytEKYQYTLAQLFAIGEINRNPQLAPNVTLGFELYDSCysdAAAIDG 105 African clawed frog
OCT90677   31 IMGGTFLihldrvysdiqft--skppelqcqmfsiEYYQSMQALIFAVEEINSDPELLPNITLGYKVFDTCytlRKAAQG 108 African clawed frog
OCA43184   21 MISGLFPvhtawidtkylft--ernppltcssfstVLYSYVQAMVYAIEEINANDSLLPNISLGYKIFDSCmhlFQSLRG 98  western clawed frog
OCT65157   41 TLGLIVPintisspkvllfk--erpvphlcdlyrrDQYKSIIALLFATEEVNKNPHLLPNITLGFQMLDSCfseDSSLRA 118 African clawed frog
OCT81641   40 LIGGVFVihsgfqlqrptfq--empqpasckdfqiRYYRDVLGLMFAIDEINTSADLLPNITLGFRLFDSCtceLRATAG 117 African clawed frog
EDL38108   55 IIGGSFSifqfsngtlsnft--apptelqasgvsmWSYRVAQSFVFAIEEINKSAHLLPNLTLGFSIRNSGdsvHGALYE 132 house mouse
OCA43208   13 LIGAVIPihidsffplvsfl--kkplpdickmfrrELYQHFQALRYVVEEINRSPDLLPNVTLGFYAYDTCsviKSELQG 90  western clawed frog

Feature 1                                                           ##                        
NP_787950 120 TVFSWLtglssviPNYTCrk-esNSAATLTGVswktsetIWTILDLYKFPQLTFGPFDpvqidrnqFQSLYQVAPKDtAL 198 house mouse
KFO36455  116 ETMSFLtgqedpvPNYVCqs-gpPRAALVGDTrsalsvaMARLLGLYKFPQVSYSSTLpslsdktqFPSFLRTRASDlTS 194 Fukomys damarensis
OCT70724  104 GSMRILtgiqkatPNYKCes-nvKIAGIVGDLqsssslaMARILGLYRFPQISYASALsdlrdkvqFPSFLRTLQSDqIM 182 African clawed frog
OCT85713  106 VMSYLSgkq-rkvPNYSCntappKLSAVVGDSpssgsvaIARILGLSLFPQISYASALptladkvqFPSFVRTVGTVdSQ 184 African clawed frog
OCT90677  109 TLSMLSgvt-gstPNYNChq-gtRLAGIVGDSgstrsilMAQILGLYQYPQISYFATSpllsnrnlFPSFFRTVPSDeFQ 186 African clawed frog
OCA43184   99 TLWALTgqd-hpiLNYKChp--nVPIAIIGDAtsgtsvaMATLLGVYRYPQVSYSASMssfsnhflYPSFFRTIPNDaMQ 175 western clawed frog
OCT65157  119 TLQAVTgnn-qnaPNYKCtp-rtKVPGILGDPlstssvaMARVLGLWRVPQVSYAASFpslsnkveFPSFLRTIVSTeGQ 196 African clawed frog
OCT81641  118 ALSVMSemr-npaPGYDChv-hsSVVGIVGELfsalslpIARVLGVLHVPQISHGSTLsalsnkrnFPSFLRTVPSNmFQ 195 African clawed frog
EDL38108  133 TMGFLTgqe-epiPNYTCqh-gsPQAALVGDTrsslsvsMARLLGLYKFPQVSHGSSLpslsdkiqFPSFLRTLTSDlTS 210 house mouse
OCA43208   91 TLWMLTglt-qeiPNYRCrd--sPLAAIIGHSkstfsilMAHILGLYKFPQISYYSTSsllsdrtqFSAFFRTVPSDvFQ 167 western clawed frog

Feature 1                                                                                     
NP_787950 199 LSGIASLMLHFNWNWVGLLIPDDqrGAQFLSDFRKELDKTkICIAFVKTVLYlgetllrliSQDHIHIIESStadVIVIY 278 house mouse
KFO36455  195 SHAITQLVLHLGWSWVGILAQDDdfGQQAGTLATQELGQAgVCIEFHLHVPSlqsm--ekiDAIVWKMEKSTatgVLVFL 272 Fukomys damarensis
OCT70724  183 PIYIINLMRHFGWTWIGLLVSDNdfGLYSSELVRKEIEAAgICVAFLMKLSAqhtr--dqtLSILQAIKKSTanvVYFYC 260 African clawed frog
OCT85713  185 PDAVVQMITHFNWTWVGILSSNNdyGDQGAQKLKTEMAKQgICVAFAKTLLTppt---kenLDTIVSVIQKSttnVIVLY 261 African clawed frog
OCT90677  187 MRGLAQLVSHFGWSWVGLLANDNeyGQLGLQIAMQEIINSgACVAFTENILTgqp---nrnAPRIARVIKEStakVVIAI 263 African clawed frog
OCA43184  176 SLALAHLISYMGWTWVGLISLDDdyGIDGSHVLKQELYKLaVCIAYHESFGIess---skrIQSVANIIDQSsarVVIIY 252 western clawed frog
OCT65157  197 PYALVELCKTFGWYWIGVLISSTdyAIQGGVVFKREAAKNgICIAYYETIALesi---sqsIPSIIKNVQSItatVIVLF 273 African clawed frog
OCT81641  196 NVALPRLIGLFGWTYVGMLVVDNdvGEQGGQVIKAGIEKSgSCVAFLEKIHLsys---mvqIQRVVNVIKKSsvnVIVLH 272 African clawed frog
EDL38108  211 SHAVTQLIIHFQWSWVIILAHDDdfGQQASSLATQMLTPAgVCIEYHLHVPShqs---fskIEETIQKMQKCtarVVLVF 287 house mouse
OCA43208  168 SKGLGQLVLHFKWTWVGLIASDDdyGYEALQVIKEEIIKSgACIAYTIYISTnqk---nqdMPNIVKLINKStanVIIAF 244 western clawed frog

Feature 1                                                                                     
NP_787950 279 GPtsiLLTLIENTYRTyn-kkKIWVMSTKWFcpn-lelYNMLELTHGALIFSPhy--keIVGFKKFMLEATPIKYp-eDI 353 house mouse
KFO36455  273 SNs-nIQLILQRLVGFcv-lgQVWVSEGLLYtvialatPGASWVLQGAFGLMLqs--grAHGFPKFFARLHPSQTp-eDM 347 Fukomys damarensis
OCT70724  261 SMp-eVIPFTQVATEQkt-sgKVWIAHASWIssp--ifSYKEFWKTLNGTIGFlypfiqIPGFGNFLYSIHPSLYp-eDI 335 African clawed frog
OCT85713  262 AYateLIALLQAVTDQni-kgKIWIAVGSWIpsa--vfSQKDLWGTLNGTVGLakysadIPGFRDFLYSIHPSQYp-nDI 337 African clawed frog
OCT90677  264 TTdsdFVIVLEELLKQnv-tgKIWIASEAWAtsdllsnERFQGILLGTIGFAIys--gqMPRFSEYLKSLHPSNYl-sDP 339 African clawed frog
OCA43184  253 SRd-pFVSMLMEYFVErqdtkRIWLATTGWSnsqmlptKLFSHTVMGTLGLSLhq--aeMPWLKKFLLNIHPSTSlpyDI 329 western clawed frog
OCT65157  274 CSpaeVSAILTEALQQnv-tgKIWIGVEAWFtspvflkTEYWNLLNGTIGISRsr--riLPYFTKFLQDFYPSRYp-rML 349 African clawed frog
OCT81641  273 SPevhVKVLLDSLYDEgl-thKILICSASFAfipgifsRKAWKVLNGTIGLIPnt--gpMPGFEQFLSSLHPSRSn-kYP 348 African clawed frog
EDL38108  288 LSnsnFQLILHGLLAVpv-sgQVWVSKDTLHmalaltiPDISQVLQSTFSLLPhs--srAIGFPEFLAHLRPSQTp-eDM 363 house mouse
OCA43208  245 SVdvfLIPLLDEMLEQkv-tgKTFVASDAWSistplttVKYSTILLGAIGFAFhs--skIQGFQEYLNSLNPINPp-gTD 320 western clawed frog

Feature 1                                                           #                         
NP_787950 354 FLHLLWYWHFNCsflhseckifenc--------lqnaslellpgniFTMTMt-eESYNVYNAVYAVAHSLHeetlsqiqf 424 house mouse
KFO36455  348 FLGRFWEATFGCrwphdndtvardvr------lcsgheslrgheypFQDIS---RVDAAYPAVYSVAHALQdmvsceqgd 418 Fukomys damarensis
OCT70724  336 FMKSFWETSFGCmwsyqgqnqsanislp---hctgeenlntlarkgYNEESv-rYAILIYNAVYSLAYGIKymildksss 411 African clawed frog
OCT85713  338 FIKEFWGHVFSCkwvdnrtendtlyygnsttfctgkeklttldssiYDTTNf-rLAVSVYNAIYAVANAIHnmlsckpga 416 African clawed frog
OCT90677  340 FIKEFWEQAFFCkwpsqtnvtlmdna------reptctgtekldslLTDVDr-rVSFNVFTAVYAIAWALHnlfnctagv 412 African clawed frog
OCA43184  330 FIKTFWEIVHNCqwpeeysvvtngtvwc---tgeekllrfkssvyeFDEFDf-rVQYLVYNAVYAVAYALHnliycltde 405 western clawed frog
OCT65157  350 NIYQFWERTFNCkwtalnstssssqtns--ktctgservitdditeYNDPIs-qFVYMAHNALYALAHALHdlmsctpge 426 African clawed frog
OCT81641  349 LIRTLWEKAFSCrwprgetqenqtnlpgllalctgeedlrglipwlFEMNDl-sYTYHAYLAVYAYAQALHtllicqapt 427 African clawed frog
EDL38108  364 FIKKFWEFTFNCtwpyqnstvtegvq------fcsgneslknkphpFPEVS---KIDAAYAAVYSIAHALHdmissehqd 434 house mouse
OCA43208  321 WSKMLWEETFNCtfsdhtnlsdilnnee---smctgkenlehihnsYNDVSslrASYNIYTAVYLIATALDdlshcqglt 397 western clawed frog

Feature 1                                                                                     
NP_787950 425 qp---qanidrtllfpWQLHPFLKKIQVknsvgdHVVLDWkRKADPEYDITNIwnfpt-glslLVKVGTFvpsapkgeQL 500 house mouse
KFO36455  419 k-----acedprhfqpWQLLHPLRKVRFqtpdgtHIMFDAnGDLVTKFDILQSqqspe-gqfhFVHIGRMe------pHR 486 Fukomys damarensis
OCT70724  412 s------sfnisqlqpWKLLHYVRKVRFnntagqELSFDTnGEQPTIPDYVNWqalpd-gstkYVKLASSkqg--sqwGT 482 African clawed frog
OCT85713  417 gpfyngtcatikdfqpWQLYYYIKNVHFlntageRVAFDEkGELKGLYDVLNWqvshd-mkgnMAKVGIFddwgpngeKL 495 African clawed frog
OCT90677  413 gplyqgacanissfhpWHLLHYVKKVNFkntagnQVFFDErGNPPAVYDIVNWhltsk-gtleQATVGKYdlsapngkTL 491 African clawed frog
OCA43184  406 epfqwklcknktdvtpWQVYHHLRKVSFvnrmgeQMYFDQhGDPPAYFDIVNWqrsqd-gtiqFLKVGWYdaraplgkEI 484 western clawed frog
OCT65157  427 gpfsggscahkqdfqqWQLLYYLKKVRFvntageLVEFDGnGDSYGNFDILNWrlvgn-ltgrYVKVGTFnnyinseqRL 505 African clawed frog
OCT81641  428 nnslyrmcanvrdmtpWKVLNYVKKTHFstntgdPISFNSdGDMPAAYDIVNVqivn--gsfnLVKVGRFdsearngnTI 505 African clawed frog
EDL38108  435 g-----kctdsqdfqpWQLLHALRKVHFkspdgvEITFDAnGDLVSKFDILQGqkipk-gifhLVHVGIIdpq--assEN 506 house mouse
OCA43208  398 gpfsggkcsdirnikpWETPISVCSQSCpvgfkkVMKKEEpVCCFQCVPCSQGeisnqtdsidCWKCPWDmwpsgardRC 477 western clawed frog

Feature 1              
NP_787950 501 SMSEYMISW 509 house mouse
KFO36455  487 SPEDRMMIF 495 Fukomys damarensis
OCT70724  483 ASKNITIFW 491 African clawed frog
OCT85713  496 VLNENSIIW 504 African clawed frog
OCT90677  492 NIDNGGINW 500 African clawed frog
OCA43184  485 VINTTAIQW 493 western clawed frog
OCT65157  506 SINTSIIQW 514 African clawed frog
OCT81641  506 LLDISSIMW 514 African clawed frog
EDL38108  507 KMMVHLKED 515 house mouse
OCA43208  478 ISKPVEFLS 486 western clawed frog

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