Conserved Protein Domain Family
PBP1_GABAb_receptor

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cd06366: PBP1_GABAb_receptor 
Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA). GABA is the major inhibitory neurotransmitter in the mammalian CNS and, like glutamate and other transmitters, acts via both ligand gated ion channels (GABAa receptors) and G-protein coupled receptors (GABAb). GABAa receptors are members of the ionotropic receptor superfamily which includes alpha-adrenergic and glycine receptors. The GABAb receptor is a member of a receptor superfamily which includes the mGlu receptors. The GABAb receptor is coupled to G alpha_i proteins, and activation causes a decrease in calcium, an increase in potassium membrane conductance, and inhibition of cAMP formation. The response is thus inhibitory and leads to hyperpolarization and decreased neurotransmitter release, for example.
Statistics
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PSSM-Id: 107361
View PSSM: cd06366
Aligned: 56 rows
Threshold Bit Score: 214.818
Threshold Setting Gi: 71656801
Created: 16-Jan-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putativeputative
Feature 1:putative ligand-binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to the Rattus norvegicus mGluR subtype I structure complexed with glutamate.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                            #                                                            
gi 94732197   135 YIGALFpmsg---gwpgGQACLPAAQMALDLVnkrtd--ilpdYELELIHYDSMCdpGEATKLLYDLLYt---ePIKIVL 206
gi 157116691   22 ILGLFElstrh-girkeGYSELAAAQLAVRHInrrg---lllgYTLKLLTNDTKCdpGVGIDRFFHALYthqdkRIMMVL 97
gi 156401189    5 YIGGFFplsgv-pvassGRDILPACKMALEMLnnrsd--ilpdYRLNLLARDTKCdvGHGIKVLYEYLSrs--tPVITLL 79
gi 118780485   72 ILGLFElssregaarreGLSELAAAQLAVQHInrrg---lllgYKLKLITNDTKCdpGVGVDRFFHALYthqskRIIMVL 148
gi 115646421  155 LLGLFElstsr-gprpdGLSELGAATMAVEHInrkr---llpgYTLELVTNDTQCdpGVGVDRFFHAIYtqpstRMVMLL 230
gi 91081455    66 ILGLFElttkw-grrpeGLSEIAAAELAIKHVnrfn---ilpeYTLKLIINDTQCdpGVGIDRFFHAIYsk--kTIVMLL 139
gi 110762270  454 YVGGIFpmse---tfysGKAILVAAMMAKEAInvnnt--ilrdYNFTLLVNDGQCksDMVMRSFINYIVhnqyeKLVGVL 528
gi 91082203   392 YIGGIFplne---stynGRGIVHGAKLAQDIInadps--ilpnYDLKLLVENGRCrpDSVTKIFIQYVTeyhynRLLGVL 466
gi 115673158  503 LLGGLFetlid--ptspNSGIEPGARMAIDAVnadln--ilpnYKLTLASMETGCspETSLLSYFKFYEdr-gqSLAGLV 577
gi 18369833   385 TVAGLFafyg----kwvVSNLDHVAEQAINFVnhnpdyfsnteYALTLDVRNLTCsqDVVLNDYFDLLTasknrKIIGVI 460
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                  ##                                                     
gi 94732197   207 MPGCSsvstlVAEAARMWNLIVLSYGSsspalsnrqrFPTFFRTHPSATLHNPTRVQLFQkwkWTKIATIQQTTevFTST 286
gi 157116691   98 GSACSevtesLAKVVPYWNIVQVSFGStspalsdrreFPLFYRTVAPDSSHNPARIAFIKhfaWDTVATFSENEegHSLA 177
gi 156401189   80 GPACSavtkvVAEVAWHWSLLQVSYAStasdlsnkekYPLLYRTVQPDSAFNSARVSVLEfygWRRVGTLRQDDfvFSSV 159
gi 118780485  149 GSACSevtesLAKIVPYWNILQVSFGStspalsdrreFPLFYRTVAPDSSHHPARIAFLMhfgWDTVATFSQNEegYSLA 228
gi 115646421  231 GSACSevtesLAKVVPYWNIVQVSFGStspalsdrreFPYFYRTVAPDSSHNPARIAFIRkfgWGTVTTFSQNEevHSLA 310
gi 91081455   140 GTSCSnvtesLAHVVPYWNILQVSFGStsptlsdrkkFPLFFRTVAPDSSHNAAKVNFVKhfgWRVIATFCQSEnkFLLP 219
gi 110762270  529 GPACSetvepLVGVSKHYKTVVISYSAegssfndrtkYPYFFRTIGENKQYKHVYLQLLKklgWKRVASLTEDGqkYTEY 608
gi 91082203   467 GPACSdtvepVTHVSKHYRTLVVSYSAegtsfsdrnkYPYFFRTIGENKDYQYVYLLLFKklgWKRVAALTEDGqkYTEY 546
gi 115673158  578 GPMCSseaevVGSVSRFLNTVVVSYQSdspslsnkdqYPYYFRTFPDTTEQCYALIELFQnfgWGRYALLSDSEdiTYKV 657
gi 18369833   461 AALCSdsiepVVEVANMRRQIVVSPTVesvrfakryqYPYFFRTVPSMTHVSLILIRLFSswgWRRVAVFRGDDh-FFDP 539
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 94732197   287 LDDLEQRVKEAgIEISVRQSFlt------dPAVAVKNLKRQdaRIIVGLFYeteARKVFCEVYKEkly-gkKYVWFLIgw 359
gi 157116691  178 VNDLVTDLELAnITCAATVSFae-----tdFKEQLKLLRDKdiRVIIGSFSheiAPMVFCEAYHLgmf-gsEYAWILQdt 251
gi 156401189  160 MSELHQSLEDHnISVVSPETFsk------ePRRHLEAIKDQdaRIIIGMFYedaARRVFCEAYKLgmy-gsQYVWILLdw 232
gi 118780485  229 VNDLVTELERAnITCAATISFae-----tdFKEQLKLLRDRdvRVIIGSFSheiAPQVFCEVYNLgmy-gaEYAWILQdt 302
gi 115646421  311 VNNLVTELEAAnISCAATITFaa-----tdFKEQLLLLRETdtRIIIGSFSqelAPQILCEAYRLrmf-gaDYAWILHes 384
gi 91081455   220 LNNLITHFENEnISCVTTITFsl-----dnYKEQLKVLKNSdiRIIIGALSselAPAIFCEIYNLgmy-gpDYVWILQdr 293
gi 110762270  609 ISYMQDLFRDNgIVFVANAKFprer-epivMTKYLQDFKQKkaKIIIADVYdqaARQVMCNAYKLemtavqGYVWFLPlw 687
gi 91082203   547 ISHMQETLGENdIAFIANTKFprdr-dpyqMSRYLEDLKHKnaRIIILDVIdsiARTVMCEAYQMkmtsadGYVWFLPtw 625
gi 115673158  658 MKNMEEVMIEGgIEMVVDIYMatnevnqaaVTSYLEEIVSKkaHIIVGYFPenvARLVLCEAHKQgltgekGYQWFLPew 737
gi 18369833   540 LIFQSNGIDLI-ADFVMKENQlty----vtVLQALKLMNDRtsRIFMVEYFakgTAIILCAAYHLgmhfdaGYVWFLNpw 614
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 94732197   360 yadnwfkik-----------------dpsinctveqmTEAVEGHVTTEIvmlnpetv---------rgasnltSQEFLAQ 413
gi 157116691  252 hisfwwle-------------------qnsacplpilLKAVENVLLVSSynsivgmgtal---sgliiwvnslFSIIIGR 309
gi 156401189  233 adnhqwwltp----------------dddvdctadqmASAVTGYFSIDSvnlertdk---------pgisgltSKEFLKE 287
gi 118780485  303 yisswwlagdl-------------petgsapctsralLTAVENLIIVSSynsivgmgtalkllflrliafsqtNDIFLQK 369
gi 115646421  385 mgapwwpd-------------------qrtacsnhelQLAVENLIVVSThnsivgnn---------vsysglnNHMFNSQ 436
gi 91081455   294 qevwwnv---------------------tthcvslelSKSVEGIILVSDynivgenn---------tsisgldNARFESK 343
gi 110762270  688 lrpewydtdryn------------qegeqvpcttaemSKAINGYLGLSHayfapd-------------ndimqEGITVRQ 742
gi 91082203   626 lnetwydtdyfn-----------kfkgesvncttaemVQAATGYFSMAHsfyapn-------------dtlvqGNVTVAQ 681
gi 115673158  738 yqdawwdtdyhnknspsysifstspssfnisctttemMQAIKGYISLSRayianw-------------dkpvpGHETVEG 804
gi 18369833   615 lssnwwqapd----------------vhprectheemHNITSWTFTVGHql---------------------iMEPLAHK 657
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                               #                         
gi 94732197   414 LMSKlggknpe-------------------------------------etggfqEAPLAYDAVWAlalalnktvgplkak 456
gi 157116691  310 FAQSlirsigyahfdsshsciqkfkmsn---yvfpderhlstetggdvtepvsqFAPQTYDAVWAialalrgaertwtqv 386
gi 156401189  288 FSRYhpng------------------------------------------tanlYVPYAFDSMWMialalnntagqlhrq 325
gi 118780485  370 LREMnvtg------------------------------------------avsqFAPQTYDAVWAmalalrgaerswsqs 407
gi 115646421  437 LRKQsaqfhgqdgfgsgygsrisiaatqsdsrrrrrrgvggtsgghlfpeaisqYAPQTYDAVWAialalraaeehwrrn 516
gi 91081455   344 LNVSkv----------------------------------------------skYASLAYDAIWAmalslkdvldfgqef 377
gi 110762270  743 WRDRyelqcqn------------------------------------keqppsnYAGYAYDAMWTyayamdrllrenqsy 786
gi 91082203   682 WMNMygskv-----------------------------------------pisnYAGYAYDAMWTyalaldklakeypaa 720
gi 115673158  805 WINEynsliek------------------------------------egkmpstYAAYAYDTVWTyayaldkllfndvaa 848
gi 18369833   658 FMPSsf----------------------------------------------sdGNLFAFDSSSHklqgtsrrfrrysnq 691
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 94732197   457 grrl----------edfnynnkditaeiyralnTSSFEGvsGHVVFDaqGSRMaWTLIEQLQggsYKKIGYYDmt----- 521
gi 157116691  387 ahknrt------rlahydytrfdmakellsqfdNLKFNGisGPVSFDg-ADRVgTTSFHQIQsgrLQLIAFFYpk----- 454
gi 156401189  326 nksl----------dqfcygdhemarllqrsteSLVFRGvtGMIEFSkkGERKqPVWINQLQewrPVHVGLYDpa----- 390
gi 118780485  408 vphrvr-------ladydytrydiaqellrqfdLLKFNGisGPVSFEg-ADRIgTTSFHQIRagqLEMIAFYYpk----- 474
gi 115646421  517 eeqsk--------ldgfdytrsdmaweflqqmgKLHFLGvsGPVSFSg-PDRVgTTAFYQIQrglLEPVALYYpa----- 582
gi 91081455   378 n-----------------yrrsdivcefvlrmsSLNFMGisGPLKFIg-ADRVgSSVLRQIQdghVRDIALFDsd----- 434
gi 110762270  787 vf---------------dlhsnhtinrltdiigETDFYGhvNNETRLv-GNFYpNVSEKQHEv-aGGKLDLNVss----- 844
gi 91082203   721 vs---------------dlhsettaeklvqliqETDFMGvsGRIKFRggPSRFsPINLMEWYgnkSHIVGHFYp------ 779
gi 115673158  849 ld---------------tlssqqtirtylrhlsNTSFSGvtGEVKFMd-QDRRgPISIHQHHpptTTIIGSYIpdmdtkd 912
gi 18369833   692 yaqdlrirkfkhplynghftnnyddspsdselqRSVFNTksEDVEYVhsSHDYaIHTYESVIvlaAALIHLLHqn----- 766

                  ....*...
Feature 1                 
gi 94732197   522 kgNLSWYG 529
gi 157116691  455 nnSLDFGC 462
gi 156401189  391 nnKIMQNT 398
gi 118780485  475 naTLDFGC 482
gi 115646421  583 tdALDFRC 590
gi 91081455   435 sgELDFEC 442
gi 110762270  845 lvWLSKSM 852
gi 91082203   780 --NISDDK 785
gi 115673158  913 qgSLSLNT 920
gi 18369833   767 psAISVFE 774

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