Conserved Protein Domain Family
PBP1_iGluR_non_NMDA_like

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cd06368: PBP1_iGluR_non_NMDA_like 
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the non-NMDA (N-methyl-d-asparate) subtypes of ionotropic glutamate receptors
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the non-NMDA (N-methyl-d-asparate) subtypes of ionotropic glutamate receptors. While this N-terminal domain belongs to the periplasmic-binding fold type I superfamily, the glutamate-binding domain of the iGluR is structurally homologous to the periplasmic-binding fold type II. The LIVBP-like domain of iGluRs is thought to play a role in the initial assembly of iGluR subunits, but it is not well understood how this domain is arranged and functions in intact iGluR. Glutamate mediates the majority of excitatory synaptic transmission in the central nervous system via two broad classes of ionotropic receptors, characterized by their response to glutamate agonists: N-methyl-d -aspartate (NMDA) and non-NMDA receptors. NMDA receptors have intrinsically slow kinetics, are highly permeable to Ca2+, and are blocked by extracellular Mg2+ in a voltage-dependent manner. Non-NMDA receptors have faster kinetics, are most often only weakly permeable to Ca2+, and are not blocked by extracellular Mg2+. While non-NMDA receptors typically mediate excitatory synaptic responses at resting membrane potentials, NMDA receptors contribute several forms of synaptic plasticity and are thought to play an important role in the development of synaptic pathways. Non-NMDA receptors include alpha-amino-3-hydroxy-5-methyl-4-isoxazole proprionate (AMPA) and kainate receptors.
Statistics
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PSSM-Id: 107363
View PSSM: cd06368
Aligned: 64 rows
Threshold Bit Score: 168.997
Threshold Setting Gi: 33860153
Created: 18-Dec-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative
Feature 1:putative dimerization interface [polypeptide binding site]
Evidence:
  • Comment:based on sequence similarity to mGluR

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                               # ##  ##                  
gi 77416864    35 SIGGLFmrnt---vqeHSAFRFAVQLYNTnqntt-ekpfhLNYHVDHld-ssNSFSVTNAFCSQfs-rGVYAIFGFYdqm 108
gi 25090493    28 HIGAIFdesa---kkdDEVFRTAVGDLNQneeilqtekitFSVTFVDg---nNPFQAVQEACELmn-qGILALVSSIgct 100
gi 55583881    28 HIGAIFdesa---kkdDEVFRMAVADLNLnneiletekitVSVEFVDg---nNPFQAVQEACELmn-rGILALVSSIgcm 100
gi 115689592   61 NLIGIFdqdvttddpkSVGFRRGMIKYNVqsnst--gspfQLMGFEVrvqvnNSFILTNLICGAls-qNRMLIAGDAdvt 137
gi 17566612    26 KIGAIFrer-----edAHIEAAVRYSVEWlsqrgiygdidLVIEYIDv---lDHYDAIKKACKMlekdHIVALLGGShaa 97
gi 118089961   35 XXGAIFdesa---kkdEEVFRMAVADLNQndeilqtekitCSVTFVDg---nNPFQAVQEACDLmn-qGILALVSSIgct 107
gi 134024502   25 HIGAIFeena---vkdDEVFQLAVSDLSLnddilqsekitYSIKFIEa---nNPFQAVQEACDLmt-qGILALVTSTgca 97
gi 118092396   25 HIGAIFegna---akdDEVFKQAVSDLNLnddilqsekitYSIKLIEa---nNPFHAVQEACDLmt-lGILALVTSTgca 97
gi 38372397    25 HIGAIFeena---akdDRVFQLAVSDLSLnddilqsekitYSIKVIEa---nNPFQAVQEACDLmt-qGILALVTSTgca 97
gi 47211653    41 ILGSLPlrwqe-eaggLRNRMFLIDDEIIgqdnggttspfLRGSSDQq---pIRRRGAVEACELmn-qGILALVTSTgca 115
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    #                                                                    
gi 77416864   109 smntltsfcgaLHTSFVTPSFptd-----------------advQFVIQMrpALKGAILSLLGhykweKFVYLYDTErgF 171
gi 25090493   101 sagslqsladaMHIPHLFIQRstagtprsgcgltrsnrnddytlSVRPPV--YLHDVILRVVTeyawqKFIIFYDSEydI 178
gi 55583881   101 sagslqsladaMHIPHLFIQRapagtprsscppttraqpddytlFVRPPV--YLNDVIFQVVMeytwqKFIIFYDTDydI 178
gi 115689592  138 tiynaasasreVKIPYFITSFaprdvy------------pdftaEYLLAMqpQVLQPLVDYIEyfhwtSLAYVYEGQagF 205
gi 17566612    98 lnaqleritddLDIPFLTAIDdlrtdm------------gkskiDFWPRP--QLFEAVVDMFThwrwnRIVLVYEGDerI 163
gi 118089961  108 sagslqsladaMHIPHLFIQRstggtprsscgltrsnrnddytlSVRPPV--YLNDVILRVITeyawqKFIIFYDNDydI 185
gi 134024502   98 sanalqsltdaMHIPHIFVQRnsggsprtvcqfnpspegeeytlAARPPV--RLNDVMLKLVTelrwqKFIVFYDSDydI 175
gi 118092396   98 sanalqsltdaMHIPHLFVQRstggsprtachlnpsleeeeytlAARPPV--RLNDVMLKLVTelrwqKFIVFYDSDydI 175
gi 38372397    98 sanalqsltdaMHIPHLFVQRnpggsprtachlnpspdgeaytlASRPPV--RLNDVMLRLVTelrwqKFVMFYDSEydI 175
gi 47211653   116 sasalqsltdaMHIPHLYIQRnsdgsprtacrlnpspggqrytlAARPPV--RLNDVMLTLVEelgwqKFIVFYDIEydI 193
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             #  #              # #                                                       
gi 77416864   172 SILQAIMEAAvqn-nwqVTARSVGNIkdvqefRRIIEEMDRRqe--------kRYLIDCeverINTILEQVVILgkhsrG 242
gi 25090493   179 RGIQEFLDKVsqq-gmdVALQKVENNink-miTTLFDTMRIEelnry-rdtlrRAILVMnpatAKSFITEVVETnlvafD 255
gi 55583881   179 RGIENFLDQTsqq-gmdVSLQKVESNinm-miTGMFRTMRVEelhry-rdtlrRAVLFMspatAKAFITEVVETnlvafD 255
gi 115689592  206 LRLHNFLELIrpl-gieVSHRRINVDt----vNETLVELKDTgk--------hRIICDTglalTNTVLRTSLDLemvtaS 272
gi 17566612   164 RRLEQLLESEeyasirfYLIKVHDGDymk-aaRQVKELEECRllhkkdcsefsRLLVDMnpehTYTFLLASLQMgl-ieL 241
gi 118089961  186 RGIQEFLDKVsqq-gmdVALQKVENNink-miTGLFATMRIEelnry-rdtlrRAILVMnpltAKSFLTEVVETnlvafD 262
gi 134024502  176 RGLQGFLDQAsrl-gldVSLQKVDRNisr-vfATLFTSMKTEelnry-rdtlrRAILLLsprgAQSFISEAVETnlaskD 252
gi 118092396  176 RGLQGFLDQAsrl-gldVSLQKVDRNisr-vfANLFTTMKTEelnry-rdtlrRAILLLsprgAQTFINEAVETnlaskD 252
gi 38372397   176 RGLQSFLDQAsrl-gldVSLQKVDKNish-vfTSLFTTMKTEelnry-rdtlrRAILLLspqgAHSFINEAVETnlaskD 252
gi 47211653   194 RGLQSFLDQTsrq-gvdVALQRVDRNisk-vfTNLFTTMRTEelnry-rdtlrRAILLLsprgAYTFIQQAVETnlaskD 270
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 77416864   243 YHYMLANLgftdi-llerVMHGGANITGFQIvnne-npmVQQFIQRWvrlderefp----------eaknaplkyTSALT 310
gi 25090493   256 CHWIIINEeindvdvqelVRRSIGRLTIIRQtf----piPQNISQRCfrgnhrisstlc----dpkdpfaqnmeiSNLYI 327
gi 55583881   256 CQWIIINEeisdmdvqelVMKSIGRLTLVRQtf----plPQNTSQRCvrnnhrintslc----dpkdpkaqmleiTNRYI 327
gi 115689592  273 FHMVYLNLdfdti-dtsnMSFGGMNLTGFSLitnksseaYQDLFGDWsdkfrdshp----------tlansnvgyEAILA 341
gi 17566612   242 KHWFLLTNmelstmdmelFRYNHARFISPYPvd-----sTFLTENRDafnfshfkehitekwamktdnsrnlkmmEAVFT 316
gi 118089961  263 CHWIIINEeisdldvqelVRRSIGRLTIIRQtf----pvPQNISQRCfrgnhrissslc----dpkdpfsqsmeiSNLYI 334
gi 134024502  253 SHWVYVNEeindaeivelVHSALGRITVIRQif----psLKDNNIRCvrnnhriaslpc----dpqegylqmlqvSNLYL 324
gi 118092396  253 SHWVYVNEeitdneilelVHSALGRMTVIRQif----plSKDNNQRCmrnnhrissllc----dpqegylqmlqvSNLYL 324
gi 38372397   253 SHWVFVNEeisdpeildlVHSALGRMTVVRQif-----pSAKDNQKCtrnnhrissllc----dpqegylqmlqiSNLYL 323
gi 47211653   271 SHWVFVNEeisdteilelSHSALGRMTVIRQif----plWRDSSSRCirqnhrissllc----dpqegylqnlevSNLYL 342
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 77416864   311 HDAILVIaeafrylrrqrvdvsrrgsagdcla-------npavpwsqgidieralkmvqvqgmTGNIQFDTy-GRRtNYT 382
gi 25090493   328 YDTVLLLanafhkkledrkwhsmaslscirk---------nskpwqggrsmletikkggvsglTGELEFGEn-GGNpNVH 397
gi 55583881   328 YDTVLLLantfhrkledrkwhsmaslscirk---------gskpwqggksmletvkkggvsglTSLLEFNDn-GSNpNIH 397
gi 115689592  342 HDLCRVAvsaarsihesgrelplprvntyhrcfkqvkegtetvastvgpelldaikrtatnqlSGRVQFDGn-GSRtNYS 420
gi 17566612   317 FDAVYAFanvfnelsshmqmndvpqtlcrkss-------rnsrkyqhgrslidnivhndlhglSGDLRRLNghPLKsNFS 389
gi 118089961  335 YDTVLLLanafhkkledrkwhsmasltcirk---------nskpwqggrsmletikkggvnglTGELEFAEn-GGNpNVH 404
gi 134024502  325 YDSVLMLanafhrkledrkwhsmaslncmrk---------stkpwnggrsmldtikkgritglTGIMEFKEa-GANpHVQ 394
gi 118092396  325 YDSVLMLanafhrkledrkwhsmaslncmrk---------stkpwnggrsmletikkghitglTGVMEFREd-GANpYVQ 394
gi 38372397   324 YDSVLMLanafhrkledrkwhsmaslncirk---------stkpwnggrsmldtikkghitglTGVMEFREd-SSNpYVQ 393
gi 47211653   343 YDSVLMLanafyrkledrkwhsmaslncikk---------stkpwnggwsmletiqkgnitglTGTMDFKDg-GANsHVQ 412
                         410       420       430
                  ....*....|....*....|....*....|.
Feature 1                                        
gi 77416864   383 IDVYemk-----vsgSRKAGYWNe--YERFV 406
gi 25090493   398 FEILgtnygeelgrgVRKLGCWNp--VTGLN 426
gi 55583881   398 FEILgtnygedrgrgVSRLATWDp--IHGLN 426
gi 115689592  421 LQIVglh-----ngvVEQVGTWSq--NNDPP 444
gi 17566612   390 MRIQllgysgrlddiGFWEPATNv--HVNMS 418
gi 118089961  405 FEILgtnygedlgrgIRKLGCWNp--ITGLN 433
gi 134024502  395 FEILgtsysetfgkdVRRLATWDs--MKGFN 423
gi 118092396  395 FEILgtsysetfgkdVRRLATWDs--EKGLN 423
gi 38372397   394 FEILgttysetfgkdMRKLATWDs--EKGLN 422
gi 47211653   413 FEILgssfsetfgkdVKRPKWNFpadKTGLC 443

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