Conserved Protein Domain Family
PBP1_GC_C_enterotoxin_receptor

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cd06369: PBP1_GC_C_enterotoxin_receptor 
Ligand-binding domain of the membrane guanylyl cyclase C
Ligand-binding domain of the membrane guanylyl cyclase C (GC-C or StaR). StaR is a key receptor for the STa (Escherichia coli Heat Stable enterotoxin), a potent stimulant of intestinal chloride and bicarbonate secretion that cause acute secretory diarrhea. The catalytic domain of the STa/guanylin receptor type membrane GC is highly similar to those of the natriuretic peptide receptor (NPR) type and sensory organ-specific type membrane GCs (GC-D, GC-E and GC-F). The GC-C receptor is mainly expressed in the intestine of most vertebrates, but is also found in the kidney and other organs. Moreover, GC-C is activated by guanylin and uroguanylin, endogenous peptide ligands synthesized in the intestine and kidney. Consequently, the receptor activation results in increased cGMP levels and phosphorylation of the CFTR chloride channel and secretion.
Statistics
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PSSM-Id: 107364
View PSSM: cd06369
Aligned: 9 rows
Threshold Bit Score: 632.489
Threshold Setting Gi: 3779137
Created: 11-May-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to NPR-C complexed with hormone peptide

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 2506471     35 YEISVLMMnnsafpeSLDNLKAVVNEGVNIvrqRLLEAGLTVTVNatFVYSEGVIYKSSDCRSSTCEGLDLLRTISSEKr 114
gi 4826752     35 YEISVLMMgnsafaePLKNLEDAVNEGLEIvrgRLQNAGLNVTVNatFMYSDGLIHNSGDCRSSTCEGLDLLRKISNAQr 114
gi 149526784   35 YELSVLMMsssafpeSLKLVRPAVELGVKLveeLLXTAGHDVQVNasFFESESPIYRSTDCRSSTCEGLDLIKGILKGKk 114
gi 1850774     29 LTMNVIMLndsmtewNIKAVQEAVSIGMHVvtkDLEREGIKVTINadFQTFNTDLYATPGCVSSGCEGVEKLKNLRHTRr 108
gi 118082606   33 YMINVMLMpdsdfpsTSENLTSAVEEALSTiqnELETEGVKVTVNasFHHFRSSLYVSQGCRTSTCEGVELIKQIFENGt 112
gi 3779137     31 ITVNVILLedeespwSLKYVGGQILEAIEKdaaINAEEGMEFNLTvnFEGFNTTLYRQRGCITSACEGAEKLNKLMVTGe 110
gi 94467210    30 YVLNVVLLeddvsewSLKFVKAGVERAIAIenqRNAEEGLNFKLTanYCGFNTSLYRRRGCGSSTCEGVEILKRLQVQNe 109
gi 94467208    30 DIINVVLLddnlsqwSLDFVKNAVNEAIIYdneLNVAAGVGFNMTasYDGYKTNQYQRKGCGSSTCEGVELLKTLTREDr 109
gi 42760897    32 YTMNVVLLedntyewSRPFVQEAVEGAIKKdaeENRKAGLNFTLTanYNWFNTNLYNRQGCGSSTCEGVAILKKLHNTGe 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                      #   #                                                              
gi 2506471    115 MGCVLLGPSCTYSTFQMYLdt---dLNYPMISAGSFGLSCDYKetLTRLMSPARKLMYFLVDFWKvnnfpfkpfsWNTAY 191
gi 4826752    115 MGCVLIGPSCTYSTFQMYLdt---eLSYPMISAGSFGLSCDYKetLTRLMSPARKLMYFLVNFWKtndlpfktysWSTSY 191
gi 149526784  115 MGCALMGPSCTYATFQMYLdm---eLDLPTISAGSFGLSCDFKetLTRLMTPARKLTNFLVDFWKmsnlpfkttpWKTSY 191
gi 1850774    109 LGCVILGPTCTYATYQMLSlk--ntFGVPLISAGSFGLSCDYHrsLARMLLPARKITYFFKEFWQyedfi-kpkkWQSVY 185
gi 118082606  113 LGCAVIGPACTYATYQMVSve--tiPSLPLISVGSFGLSCDYKenLTRLLTPARKVNDFFYYFWNeiqqpfktstWESVY 190
gi 3779137    111 LGCAVLGPTCTYATFAIADvekgfnLSTPIISAGSFGSSCDYAmnLQRLLPPARKISDFFINFWKekft--ikpkWRTAY 188
gi 94467210   110 VGCAMLGPSCTYATFHLVDlengfnLSVPIISAGSFGLSCDYKayLTRLLPPARKISNLFIEFLRfeess-lkprWEAAY 188
gi 94467208   110 TGCVLLGPTCTYATFQMVDtevgliMGLPIISAGSFGLSCDFKdnLTRLLPPARKISSFFLDFWNysef--lkakWTTAY 187
gi 42760897   112 VGCVMLGPSCTFATFQLVDeeiglsLSIPVISAGSFGLSCDYKpkLTRILPPARKVSDSLVYFFNeknm--lkpiWEKAY 189
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                     ##  #  ##          #                                                
gi 2506471    192 VFKNSTE-SEDCFWYLNALEAGvsYFSQKLSFKEMlrgneefQNILMDQNRKSNVIIMCGAPetVHTLKGGRAVAe--DT 268
gi 4826752    192 VYKNGTE-TEDCFWYLNALEASvsYFSHELGFKVVlrqdkefQDILMDHNRKSNVIIMCGGPefLYKLKGDRAVAe--DI 268
gi 149526784  192 VYKNQNL-SEDCFWYLNALEAGvtYFSGILEFKEVlrneeqfQAFLTDQNRKSNVIIMCGTPeiVSEIVGGRQVDe--DI 268
gi 1850774    186 IYKWDGN-TESCFWYINALESGvsYFNNALKFKEIlrtegelMKVLQENNHKSNVILMCGTPndIWNLHNKVAIPq--DK 262
gi 118082606  191 LYKKTDN-SEQCLWYMNALDAGvtQFSEKLKFKDIvrtqdqfRRLVKNPKRKSNVIIMCGTPadIRQDLGTETVDk--DI 267
gi 3779137    189 VYKRQPN-TEDCLWYIGALEADgrFLVNVSRTILRhpg-dlkDVLDSQENRTSNLFILCGSPtdLKEVKNISDAAdnlDI 266
gi 94467210   189 VYKKPEN-SEACFWYINALDAPsaAFSSAIRRTVLrkp-eelHSAFERKNRTSNLFIICGTPedVANLTDNGRRLe-pEM 265
gi 94467208   188 VYKKPEQ-TEDCFWYINALEARsaEFSSNVARHVLqrp-edlRSEINNKRRKSNVFILCGSPgdIVNLTKDIDRKlhpEV 265
gi 42760897   190 VYKKSNNvTEDCFWYNNALEAPsaHFASSKKREMLrge-eelKKALTSKYRFSNIFILCGSVddIVSIKGLAKQFh-eDT 267
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 2506471    269 VIILVDLFNDHYFmdnvtaPDYMKNVLVLTLPPENs--vSNSSFSKDLSLVKn--DFTLAYMNGVLLFGHMLKIFLEKRe 344
gi 4826752    269 VIILVDLFNDQYLednvtaPDYMKNVLVLTLSPGNs--lLNSSFSRNLSPTKr--DFALAYLNGILLFGHMLKIFLENGe 344
gi 149526784  269 IIILVDLFSSKYFedpkqsADYMHNVLVVTLPPPPdnytFGEGYPHGSSLLKd--EFAVAYLDGVLLFGHMLKKLLQNKe 346
gi 1850774    263 VLILLDIFNTVYYdnk-ssPYYMENVLVVTQRPSNm--sKISNQTGIAKLLEd--NYAAGYLDGVLLFGHILKKFLGSVd 337
gi 118082606  268 VIILIDLFKNTYFrnt-tsARYMQNVLVLTLPPANn---NFSTRTTDTSLLEd--DFVIGYYNAVLLFGHILKKFIFSQs 341
gi 3779137    267 LFILIDLYNDVYYtnt-tsMPEMRNVLVLTMPDTRt--yTIKPDLTGNDTMN---DYMAAYHDAVLLVGQVMRDIAIRNp 340
gi 94467210   266 VILLIDLYNHEYHsa--agSPAMSNVLVITMPNIR----NYTEGWTDNGTLPemnDYVAGYHDGVHLFGSVLRRKMLYGe 339
gi 94467208   266 IFILIDLYSPAYHlnt-tsIPPMENVLVLTMPKRNf--tNQIDPTTNDTVMT---DYMAAYGDGVLLVGQVLRRLWEEKp 339
gi 42760897   268 IFILIDLYNPEYYint-tsLAPMRDVLVVTLPPRNy---VNESNSTFNNTIN---DYVAGYHDSALLFGEVLRRKMLSQh 340
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
Feature 1                                                                                    
gi 2506471    345 d--vTTSKFAHa--FRNITFEGHMGPVTLDNCGDIDNTMFLLYTSvdtskYKVLLTYDTrknYTNPVDKSPTFIW 415
gi 4826752    345 n--iTTPKFAHa--FRNLTFEGYDGPVTLDDWGDVDSTMVLLYTSvdtkkYKVLLTYDThvnKTYPVDMSPTFTW 415
gi 149526784  347 ---tLDFSFGRl--FRNLTFPGALGPVTVDEFGDVDSNMTLLYTSmgnnkYKVLMHYDThqnKSYPRDPDPTFIW 416
gi 1850774    338 i--nQTFSFIDq--FRNISIIGALGPLILDAAGDRELNLTLLYSStatnnYTELIQFDTstnQTTVMDTSPNFIW 408
gi 118082606  342 p--vLPTSFINe--FRNITFEGAQGPVTLDEFGDIDNNLTLLYTTqsasdYRVLMYFNTqenDTYVVSTSPDFIW 412
gi 3779137    341 a-emQGMEYVNtnyFRNVSFNGIGGHYKLDSYGDRDVNFSVIYTStd-nkYKILFSFDTennRTKQMDPSPTFIW 413
gi 94467210   340 gsveEDASVENp--FKNISFSGIGGQYVLDEHGDRDVNFSVMYMSttdsqYKVLFEFDTstnNTAVVDANPTWHW 412
gi 94467208   340 g--rKQFSINMe-dFRNLSFTGLGGHYVLDEYGDRDVNFSVMYTTka-meYKTLFEFDTatgLISVKDDKPDFFW 410
gi 42760897   341 ----VPLSDTP---FGNISFEGMAGNYVLDEYGDRDVNFTFIYTSaqtskYETLSVFDTsqnITIMWHDSPTLPW 408

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