Conserved Protein Domain Family
PBP1_Speract_GC_like

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cd06370: PBP1_Speract_GC_like 
Ligand-binding domain of membrane bound guanylyl cyclases
Ligand-binding domain of membrane bound guanylyl cyclases (GCs), which are known to be activated by sperm-activating peptides (SAPs), such as speract or resact. These ligand peptides are released by a range of invertebrates to stimulate the metabolism and motility of spermatozoa and are also potent chemoattractants. These GCs contain a single transmembrane segment, an extracellular ligand binding domain, and intracellular protein kinase-like and cyclase catalytic domains. GCs of insect and nematodes, which exhibit high sequence similarity to the speract receptor are also included in this model.
Statistics
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PSSM-Id: 107365
View PSSM: cd06370
Aligned: 13 rows
Threshold Bit Score: 498.779
Threshold Setting Gi: 33302603
Created: 12-Jul-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to NPR-C complexed with hormone peptide

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 118063      39 IHVGLLAewttad--gdqgtLGFPALGALPLAIslanqdsnilngfdVQFEWVDThc----diNIGMHAVSDWWKr--GF 110
gi 4579919     51 LKFGLLAewttp---dgdqgHAFPTVGVLPLVLstlnidpdrfdgydLQFDWVDThc----diNLGLEAVSRWWKegyVG 123
gi 118062      40 LHIGMLTswtna---dnsqgTGFPSAGAFPLAIqyanndmdilhgydINFEWVDThc----diNLGMAAISDWWKr--GF 110
gi 18844747    23 FKIGLLVpltdpq-tgnasgFGDPVAGAFPVAVddinlnpailpghtVSWEWVDTkc----diNTGLTAVSDWWKr--GF 95
gi 24666940    26 LTVGYLTaltgd----lktrQGLAISGALTMALdevnkdpnllpnvyLDLRWNDTkg----dtVLATKAITEMICd--GI 95
gi 17534659   123 KKLNQIVhclt------tdaYVSVVSGALVAAIveinqdkdlipayqLKYVFGNTcg----ndSHSTRLFMEHWQa--GA 190
gi 158597957   62 KNYGYLSkcfr------tdfEGSMISGALQVAVddvnadpellpnhkLIYTFNNTcg----deQQSTRFFMQHWAq--GA 129
gi 86285413   113 LFVGFLPtrqgg----rkerLGIKIPGAFTYSAeqvnekgilpegykLKYEFFDTrg----eeVMGSSIMVDLLCr--NV 182
gi 115686179   95 IKVGYLAssssd----sikrFAMRIGGAMTEAVnavnadknllpgykMKYVWTNTgh----teRESIRALTEQWKs--GV 164
gi 33302603    44 INIGFLAey----------sQMRVTLGGLPLAIedvnknpnllpgkkLAFKPVDIghkmsayrVKPLRAMTQMREa--GV 111
gi 115617908   36 ITLGFLApdkt-----kvarLVRFNGGAMTVAVrdvnnnpdmlpgyrLQFRWLDTyg----neEGSIRALSDQWRd--GI 104
gi 52630412   135 ILVGFLPtrvgd----rrerLGLKIPGAFTYAVenvnnksilpdnyiLSFEVQDTeg----keDLSSKHVVDMLCk--GV 204
gi 24663839    41 FTLGYLTasqrrpgnldynrPGLTISGAISLAVeevnagrlrdrghsLQFVVAETyg----eeVVSIRQTAALWTq--QV 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                   #   #                                                                 
gi 118063     111 VGVIGPGCGCTYEGRLAsaLNIPMIDYVCdenpv-sdksiYPTFLRTIPPSIQVVEAIILTLQRyELDQVSVVVENIt-- 187
gi 4579919    124 VFGPGPGCGCTYEGRLAaaVNIPMVDYGCdenpv-sdkniYPTFIRTLPPSIQVIDSIMLTLERyDWDQLSFVMKNNs-- 200
gi 118062     111 LGVIGPGCGCTYEGRLAsaLNFPMIDYACdenpv-snkefYPTFLRTIPPSIQVVDSILLTLDMyDWNQVTVVVENIt-- 187
gi 18844747    96 VGVIGPGCSCDYEARLAgsINFPMFDYGCdegav-snkllYPTYIRTLPPSTRIVDALIVTLQKfDWDQVTVVYRNHs-- 172
gi 24666940    96 ATIFGPEGPCYVEAIVSqsRNIPMISYKCaeyr----asaIPTFARTEPPDTQVVKSLLALLRYyAWNKFSILYEDV--- 168
gi 17534659   191 RVFIGPEKNCKTEAAMAasQNLPIISYRCndqdisrddyhYRTFARTVPPAGEIFKAFMSLMKQyNWRKFSVVYDVKkgq 270
gi 158597957  130 KVFIGPEMNCRTEATMAaaQNLPILSYKCkdemm-sdkskYPTFARTVPTETEITAALIALFKHfEWRKFSIIYERNv-- 206
gi 86285413   183 SAVFGPEHTCFVEGTIAegHNLPMLSYGCtnei----askFKTFVRTNPSEIYVIRTAVAAMKHnNWTRFSVIYERD--- 255
gi 115686179  165 TAFFGPNPTCSIEAKIVsaWELPMLSATCaeskl-sdksiYPTFARTIPTDDLLTEAVSVLLEYfNWYNVSIVSSSEs-- 241
gi 33302603   112 TAFIGPDESCTTEALLAsaWNTPMLSFKCsdpiv-snkstFHTFARTLAPASKVSKSVISLLNAfHWNKFSIVVSSKpi- 189
gi 115617908  105 VAFIGPGLTCTTEAKVAaaWNLPMISYFCkepav-sdketYRTFARTVPTTEKVSESVLALLKQfNWNVVSVVAAKDl-- 181
gi 52630412   205 SAIFGPEHTCYVEGTIAqgKNLPMISYACsner----askFTTFVRTNPSEIYIIKTTVATLRHnNWNKFSIIYTED--- 277
gi 24663839   115 AAYIGPQETCVHEGRMAaaFNLPMISYYCthrdp-snkadFPTFARTRPPDTQISKSVVALLLAfNWTQVSFLYLDDasg 193
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           ##  #  ##                #                                                    
gi 118063     188 kYRNIFNTMKDKf------dERDYEILHEEYYagfdpwd------yemddpfSEIIQRTKETTRIYVFFGda-sdLRQFA 254
gi 4579919    201 kYVGIFETIRTIf------rLRDYEILHEEYYtdfdawd------yemadpfVDIIQRTKDTSRIYLFLGea-qeLRQFA 267
gi 118062     188 kYRNVFNTMKEQfd-----mREEWEILHEEYYagfdpwd------pdaaepfTDIIQRTKKTTRIYVFFGds-gdLRQFA 255
gi 18844747   173 iWTNILNAMKEEf------eVHDITVQHQEVFqtgfvpnn-----dsiinpfPEIFTRTKETTRIYVFLGem-ieLRSFA 240
gi 24666940   169 -WSPVADLLKDQa------tKRNMTINHKQSFidnrvkcceqmldccrsgywYQLVQNTMNRTRIYVFLGaa-nsLVDFM 240
gi 17534659   271 vKNELFETLKRMvetenkfeEHKFEIMNVSKLefskmdis----sqqdiqsiENAIKSTMQTTRIYLTFDnv-rlFRTML 345
gi 158597957  207 aNEELFRSIKSTie----kqNMGLEVSDTHYViinvstvphp-fseiersniKQIISDTYVSTRIYLTFGnv-rlFRRIL 280
gi 86285413   256 -QESTKDTLVWEa------eRSNMTVNHVIPYdkd---------------rlYLILDATKNATRIYVYVGhr-nlVEQLL 312
gi 115686179  242 nRLSVSESLQLKl------pTKNIHISDVKIYaspyipplye-pengvepemRAIVRETYEHTRIYIFIGel-weVYELL 313
gi 33302603   190 wGSDVARAIQELa------eARNFTISHFKYIsdyiptt-------ktlsqiDKIIEETYATTRIYVFIGeh-iaMVDFV 255
gi 115617908  182 qFSRVMTRLEKFl------pLHGIKVQHAFSYenpyypip-----pikdnrlKDIIEQSYTNTRIYVFIPaepyeLHAFL 250
gi 52630412   278 -NHSMKDTLIVEa------eKENMTINHQILYnvd---------------qlPFVLQETKHSTRIYVFIGhr-nsVNNLL 334
gi 24663839   194 qYQPVAETILSTl------tDAGVSIRDIRTWntiyhhg-------fmdnpfEALVEQTYANTRIYLILGhy-yeHVGLM 259
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 118063     255 MTALDEgild----sgdYVILGAvvdlevrdsqdyhsldyildtseylnqinpdyarlfknreytrsdndraLEALKSVI 330
gi 4579919    268 MTCLDEgimd----ggeYHILAPvidvvirdsqdyhslqytidstryissinidymrrfqyreytrtdddkaALAMAYVT 343
gi 118062     256 ISALDVgiln----sgdYAIVGAvidleirdsqdyhsleytleasdyleqinqayeqmfklreytrtdderaLEAMKSVL 331
gi 18844747   241 MAALDEgln-----ngdYAILGMaidhkirrsqnwhs---------------------ldflhmgtyldekaAKAMESVL 294
gi 24666940   241 SSMETAglfa----rgeYMVIFVdmmvysereaekylrr-----------------vdqitfmsnchstenfNQMARSLL 299
gi 17534659   346 SIMGEMglt-----qqdYMLIYVdtnydwlnvyhsmnnhflrn----------tmtylhhswdannssdrkmLDYARSAL 410
gi 158597957  281 LEMGAQglme----sgdYALIYLdpdynwlntyhamnnhffrd----------tllsvkqswddlnsqdrkvVNFSKFAL 346
gi 86285413   313 NVMAMTgmfpagqgpkeYLLLYIeneeynsddwlqyiw-------------------gniaseqknkcrtkdLLPFDKAF 373
gi 115686179  314 HEMMYHglle----ngeYMVIWAnqenfdykqlhlf-----------------------qgdpylrqpsrevMMYYRTLL 366
gi 33302603   256 RGLQNRrlle----sgdYIVVSVddeiydsnrrvn-------------------------imernyldpyirKEKSKSLD 306
gi 115617908  251 EDLDEKglld----dgdYIVVAIffkifdesnrdglik-------------------gvyypaegpdgisqrIRYMHNVL 307
gi 52630412   335 TVMAMTgifkpketekkYLLLFVdreeympddwlsyiwdf----------------rshgeivsskqcferdVDAYNGAF 398
gi 24663839   260 VSLQRRgils----kgdYFVVGIdieqydpakpeky-----------------------lrgllledveplaVQAFQSYL 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 118063     331 IVTGapvlktrNWDRFSTFVIDNAldapfngel--------------------------------elraeidfASVYMFD 378
gi 4579919    344 LITGvpvfqsiQWDWYSILVLENAlrdpfngdl--------------------------------elkadidyGSIYLWD 391
gi 118062     332 IVTGepvlrsqAWHIYSAIVIDNAldepfngtl--------------------------------elktdidmASVYIFD 379
gi 18844747   295 IIAPkapkftfVYKSWNVKVRDSVqgapffq-----------------------------------tgrefhtFSAFLYD 339
gi 24666940   300 VVAStpp--tkDYIQFTKQVQKYSskppfnleiprl-------------------------fvesnfskfisiYAAYLYD 352
gi 17534659   411 SIIPtpv--klNSQRFYNFWKKAGdymhhfgvq-------------------------------kadnlkgnrIACYLYD 457
gi 158597957  347 AIIPtpv--qlNAPEFVAFWRKANhylslfgvkqs----------------------------statsikanrFACYLYD 396
gi 86285413   374 MVVAnr---kpEFNEFSQRVREYNkrapfclghdn---------------------------ngnrprdipylPSAHLYD 423
gi 115686179  367 ALFLspa-tdpSYDNFQRKTYKKLqeppfnfdfg-----------------------------davdvlgipiEAAYLYD 416
gi 33302603   307 KISFr------SVIKISMTYPQNPhir-------------------------------------------vpiYGLHLYD 337
gi 115617908  308 MLFYtsa-mspDFNGFKIEAKAYLseppfnfdsgll--------------------------eelgypieiteDAAYLYD 360
gi 52630412   399 VVVAnrf--pdDGSSLKESVREYNkkppfclgfhssli---------------------rdrpiseemhipylPSAYLYD 455
gi 24663839   313 GIVPt------ASVSFATFANEVCpltgpdsdvidalhppsarliivnkymerppfnfpnplgpfggvkqisaEAAYLYD 386
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 118063     379 ATMQLLEALDRTHAAGgdi-----------ydGEEVVSTllNSTYRSKtdTFYQFDENGDGVKPYVLLHLipi-pkgDGG 446
gi 4579919    392 AAMQFLQVLENAILEGrdi-----------ynGTELVRQmfNTTYYSKgeRWHQFTNNGDGVKPYALLHWipi-pegDGG 459
gi 118062     380 ATTELLKALDATLQAGgdm-----------ydGSQVVSNlfNTSYRSKakADYQFDENGDGVKSYVLLHRipi-pvgDGG 447
gi 18844747   340 ATILFAKALEETLAAGedp-----------fdGEAIVSHamGVQYQSIsmLQNGIDESGDGISRYMLMDMnel-qeaDSW 407
gi 24666940   353 SVKLYAWAVDKMLREEtrvltddvifevasngTRVIDTIikNRTYMSItgSKIKIDQYGDSEGNFSVLAYkph-kwnNSN 431
gi 17534659   458 AVYLYAKAIHELVEEYgnddsy-----dptadGKAIIDRivNKKYRSIqgFDMRIDERGNSKGNFSLLSWqkv-apiMNK 531
gi 158597957  397 AVKLYASALTMVLNETaneqlsv--gydpisdGKRIIGHilGRVYRSIqgFDMHINSNGDAQGNYTLLSLqei-epvLDM 473
gi 86285413   424 SVQLYARVVAELYEELkdqnvsv---reiasnGTLIKDKlrNITYESIlgFNMTMNINATSEGKYSVYLFsd---cpNAT 497
gi 115686179  417 NVYNVYAPALNETLAAgyd----------irnGTEILRRilCRKHASItgRPKYIDARGDAYADITVIAVklg-edvDET 485
gi 33302603   338 SVMIYVRAITEVLRLGgdi-----------ydGNLVMSHifNRSYHSIqgFDVYIDSNGDAEGNYTVITLqndvgsgASI 406
gi 115617908  361 AVMLYAKALNQTLSEGgsi-----------tnGTDIISNilDKTYQSItgVNRIIDKDGDTIANVSVFSIq------RNS 423
gi 52630412   456 SVQLYARAVSELYDAEksnnvtv---eeiarnGTKIKNHlkNITYKSIlgFDMTMNINASSEGKYSVYYFsnc--rnSNQ 530
gi 24663839   387 AVHLYAKALMEVLDSGgrp-----------rnGSAIVAAikGSRYRSAmgYHVYIDENGDAAGNYTVLARgs----vRNG 451
                         490
                  ....*....|....
Feature 1                       
gi 118063     447 ATKDSlgmyPIGTF 460
gi 4579919    460 AGAGSmgmyPVGTF 473
gi 118062     448 MPPGSpgmyPIGTF 461
gi 18844747   408 LTAGYpgviGVGEF 421
gi 24666940   432 NMPCNyhmvPVAYF 445
gi 17534659   532 SDPSYypldHALDL 545
gi 158597957  474 DNPDYyplnYGLDI 487
gi 86285413   498 TTNCSlclhKISDY 511
gi 115686179  486 FGYIMhpvaTIKIT 499
gi 33302603   407 GSLAKmsmqPVGFF 420
gi 115617908  424 SSDIDyvidPVAIF 437
gi 52630412   531 DVQCSkclyKISDY 544
gi 24663839   452 RNQTVlglrPVGTF 465

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