Conserved Protein Domain Family
PBP1_sensory_GC_DEF_like

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cd06371: PBP1_sensory_GC_DEF_like 
Ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues
This group includes the ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues. They share a similar topology with an N-terminal extracellular ligand-binding domain, a single transmembrane domain, and a C-terminal cytosolic region that contains kinase-like and catalytic domains. GC-D is specifically expressed in a subpopulation of olfactory sensory neurons. GC-E and GC-F are colocalized within the same photoreceptor cells of the retina and have important roles in phototransduction. Unlike the other family members, GC-E and GC-F have no known extracellular ligands. Instead, they are activated under low calcium conditions by guanylyl cyclase activating proteins called GCAPs. GC-D expressing neurons have been implicated in pheromone detection and GC-D is phylogenetically more similar to the Ca2+-regulated GC-E and GC-F than to receptor GC-A, -B and -C which are activated by peptide ligands. Moreover, these olfactory GCs and retinal GCs share characteristic sequence similarity in a regulatory domain that is involved in the binding of GCAPs, suggesting GC-D activity may be regulated by an unknown extracellular ligand and intracellular Ca2+. Rodent GC-D-expressing neurons have been implicated in pheromone detection and were recently shown to respond to atmospheric CO2 which is an olfactory stimulus for many invertebrates and regulates some insect innate behavior, such as the location of food and hosts.
Statistics
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PSSM-Id: 107366
View PSSM: cd06371
Aligned: 19 rows
Threshold Bit Score: 529.161
Threshold Setting Gi: 1345920
Created: 12-Jul-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to NPR-C complexed with hormone peptide

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        #
gi 1706243     54 KIGVVGPWaCDSLFSKALPEVAARLAIeRINRDPSFDLSysFEYVILNEDCQtsRALSSFISHHQMASGFIGPTNPGYCE 133
gi 47209256    29 KVGVLGPWnCDPVYHRAFPAAAAKLAGsRMNRDPSLDLGleMEFVTLQEPCEtsKALNAFIYYEGMVDAFVGPINPGYCA 108
gi 1840403     54 KVGVLGPWnCDPVYYRALPTVAARLAIsRINRDPNLDLGltMDFIILQEPCEtsKAHTTFIYYDKSANAPVGPTNPGYCI 133
gi 169259780   59 KVGIIGPWnCDPNYAKSLPAIASRLAVgRINNDFSLDLGctMDFVILQEACEtsKALTSFVQYENVADAFVGPTNPGYCN 138
gi 47210702    17 RVGVVGPWeCDPLFAKALPHVAAQLAVnRINRDPSLSYAatFDYIVLQEPCEtsRALEAFLGFHTKAAGYIGPANAGYCD 96
gi 4521264     67 RVGVVGPWgCDPIFAKALPSTAAQLAItHINRDPSLSSAgaFDFAVLQEPCEtsRALETFVGFHTKASGYIGPVNPGYCD 146
gi 149519475   76 TVGVLGPWeCDPVLATAFPGVAAQLALdRVSRDLSPRQGfqMTYEVVPEACQtpQALAAFAARRSQVAAFVGPAVPGYCK 155
gi 126309158   43 TIGVLGPWsCDPIFSRARPDLAARLAAtRMNHDQALEGGpwFEVILLPEPCRtsGSLGALSPSLARVSGLVGPVNPAACH 122
gi 73988127    11 TLGVLGPWdCDPIFAQALPSVAAQLAVdQANQDSSLVLGsrLVSVVLPTGCDtpHALATFLAHKNTIAAFVGPVNPGYCQ 90
gi 157841189   59 KVGVVGPWsCDPIFTKAQPGVAARLAVaHINKDPYLSQGitFDYIILDEDCEtsKSFARFLGYYTRASGFIGPVNPGYCE 138
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            #                                                             ##  #  ##      
gi 1706243    134 AASLLGNSWDKGIFSWACvnyeldnkisyptfsRTLPSPIRVLVTVMKYFQWAHAGVISSDEDIWVHTANRVASALRSHG 213
gi 47209256   109 AASLLSKNWDKALFSITCvnyelehtvgfptfaRTLPISVDVLFNVLKHFRWANVAVVSSNEDIWRDTAGRVSTALRDRG 188
gi 1840403    134 AASLLAKSWDKALFSFSCisyeldrltayptfaRAAPFPADVLFTVFKHYRWATSVVISSNEEIWIETAGRVASALRMKG 213
gi 169259780  139 AAALMSKNWDKSLFSWACvnheldrvqgyptfaRTLPSPLRVLFNVLKFFRWANIGIVSSNEDIWIDTAAKLASALRNRG 218
gi 47210702    97 AASMLSKGWNKAVFPWGCvgyelddlrshptfaHSMPRPTSVLLSVVRYFRWAHIGIISSSDDIWVETANKVADALRSHG 176
gi 4521264    147 AASMLTKGWNKAVFPWACvgyelddvrshptlaRSLPRPTWVLHNLLSYFRWAHIAIISSYEDIWVETAIKVADSLRSHG 226
gi 149519475  156 AAALLGQTWGVPLLSWACgledstltsglgalvPTLPPAGTVLLTFMGHFGWAHAAVVSSHHDMWVDTGRQLAAAFRTQG 235
gi 126309158  123 PAELLAQEAGVPLVPWGCpqgka------rttaPALPLALDALYALLRAFHWAKVALITAPQDLWVEAGQALAGGLRSRG 196
gi 73988127    91 AAALLAQGWGKTLFSWACgapeg-----gselvPTLPSAAHVLLSIMRHFGWAHVAIVSSHQDIWVATARQVAMTLRTHG 165
gi 157841189  139 AASLLGKSWNKAVFSWSCiehelddvrshptfaRTMPVPSLVLLSFMRHFRWAHVGIISSSEDVWVEAAIKLANALRSHG 218
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             #                                                                           
gi 1706243    214 LPVGVVLTTgqdsq-smrkaLQRIHQADRIrIIIMCMHSa-LIGGETQMHLLECAHDLkmtdgtYVFVPYDALLYSLPyk 291
gi 47209256   189 LPVSLVTSMgmnkt-evessLRNIQNAGGVrVIIMCMHSv-LVGGEQQATFLLKAKEMgltggqYVFVPYDTLHYSVPyn 266
gi 1840403    214 LPVGFVAAMgmndt-elestLKKIQSTGGVrVIIMCIDSv-LVGGEQQAVFLLKAKQLgltsgkYVFVPYDTLHYSVPyt 291
gi 169259780  219 LPVGIVTSMgnndt-mlentLMSIKNAGDIkVIIMCMHSv-LIGGEQQATFLTKAYDMglasgrYVFIPYDTLLYSLPyi 296
gi 47210702   177 LPVRLVSFMentph-airhtLSKVRKMKELrVVILCMHSv-LIGGEVQKLLLETAYDMemidgsFVFVPYDTLLYSLPyr 254
gi 4521264    227 ISVRLVSFMentph-girqtLSRVHKMQEIrAVILCMHSa-LIGGSAQKLLLEAAYDMkmtdgsLVFVPYDTLLYSLPhr 304
gi 149519475  236 IPGVLEASLgpdgq-gvsktVQQLKGADRLkVVVLCMHSalAAGGEDQVAFLTAAHAAgltdgrLVFVPYDALLYSLPyq 314
gi 126309158  197 LPVAMVTSLettdlesaknaLKRVRDGPKVkVLIMVMHSv-LLGGEEQRLLLEAAEELglvegtMVFLPFDTLHYALPpg 275
gi 73988127   166 LPVGLVTSLgpgeq-gatevLEQLCSVDGLkIVVLCMHSa-LLGGLEQTALLSRAWAQgladgrLVFLPYDTMLFALPyr 243
gi 157841189  219 LPVGIVTSArndht-svrqtLAKVRKVADLrLVILVMHSv-LIGGRTQKLLLETAHDMrmtdgsLVFMSYDTLFYSLPyh 296
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 1706243    292 htpyqvlRNNPKLREAYDAVLTITVe-sQEKTFYQAFTEAAARGEipeklefdQVSPLFGTIYNSIYFIAQAMNNAMKEN 370
gi 47209256   267 nvshkplQSNSQLREAYDAVLTITVa-sEPLSFNEAFAAAKENQEvtldvrpeQVHPLFGTIYNSIYILARSIHNTRKGG 345
gi 1840403    292 nvshfalKNNSSLKEAYDAVLTITMa-sEPLSFNEAFEAARKSGEitlpvqpeQVNPLFGTIYNSIYLMARSIHNARKAG 370
gi 169259780  297 nityyplQNNSKLSKAYDAVLTITLd-sDIMTFNEAFNAAKQLGElmvtqepeQVSPLFGTIYNSLYLLAKSMHNARRAG 375
gi 47210702   255 nvtyaalKSNGKLLRAYDAVLTVTId-sPRMSFYESYREAMEKREvaatlkpqEVSPLFGTIYNSIFFMAHAVHHLRQSG 333
gi 4521264    305 nitypalKSNSKLLRAYDAVLTVTId-sPHTSFYETYREVMERGEvpttlkpqQVSPMFGTIYNSVLLMAHAIKGVRDSG 383
gi 149519475  315 nrsfpalRRDSQLRRAYDAVLTVSLe-sGEEPFHEALAAARARGEitadldpeQVSPLFGTIYDAVYLLTYALYRAPQPR 393
gi 126309158  276 pealrpiTNSSRLRKAHDAVLTLTRy-cPKGSVSASLRQAQEHRElpldlkpqQVSPLFGTIYDAIYLLAGAVAGAQVAG 354
gi 73988127   244 nhsylalGNSGPLQEVYDAVLTISL---ESDPVDKAFEAAKASGEvaahlepeQVSPLFGTIYDAVVLLAHALNRSESHG 320
gi 157841189  297 hvtqpalRYNSKLLRAYDAVLTITIespKEQSFYQAFEKAQEDGElpkhlkpqQVSPLFGTIYSSIVFMAHAVQSVRAAG 376
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
Feature 1                                                                            
gi 1706243    371 gq--aGAASLVQhsRNMQFHGFnQLMrtdsNGNGISEYVILDTnlkeweLHSTYTVDmemeLLRFGG 435
gi 47209256   346 ms--lSGSNLAYftKNIDFTGFnQNVkvdsQGQIRSSYVVLDTdstgshLYRTYTVDlvsqRLRFAG 410
gi 1840403    371 mt--lSGSNVAYytKNTNFDGFnQRFevdsRGQVKTSYVVLDSdskgaeLYQAYVVDlrsgVLRFTG 435
gi 169259780  376 rw--lSGTNLAYftRNITFTGFnQDIqtdeQGNGQTNYVILDTeawgtqLYRCFLVDmtsdLVLFAG 440
gi 47210702   334 ew--mSGGNLARrtRNLAIQGFsHWLrtnaSGSALVDYLILDTdglsweLKPVYRIDmeagSVRFLG 398
gi 4521264    384 aw--iSGGNLAHqtRNLNFQGFsHRIktssSGAVQLDYLILDTdgssseLLPTYRIDmeigMVRFLG 448
gi 149519475  394 vp--lTGSGLAQllGSLNMAGFsRRIrtdeKGVGRATYVVLDTdgrgdqLFATHVLDpsgpSVQALG 458
gi 126309158  355 gggwvSGAAVARhiPNTLVSGFcGDL----GGTKEPPFVLLDTdgmrdqLLPTYTLDpaqgVLHHAG 417
gi 73988127   321 ag--lSGARLGDhtGALNVAGFsQRIrtdeKGRRLAQYVILDTdgrgsqLVPTHILDtgtwQVQPLD 385
gi 157841189  377 qw--mSGGNIAQnaRNLLFKGGsSLQan-sSDFGMLDYVILDTdgfsweLQPTYRIEmqtdMVRFLG 440

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