Conserved Protein Domain Family
PBP1_NPR_like

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cd06373: PBP1_NPR_like 
Click on image for an interactive view with Cn3D
Ligand binding domain of natriuretic peptide receptor (NPR) family
Ligand binding domain of natriuretic peptide receptor (NPR) family which consists of three different subtypes: type A natriuretic peptide receptor (NPR-A, or GC-A), type B natriuretic peptide receptors (NPR-B, or GC-B), and type C natriuretic peptide receptor (NPR-C). There are three types of natriuretic peptide (NP) ligands specific to the receptors: atrial NP (ANP), brain or B-type NP (BNP), and C-type NP (CNP). The NP family is thought to have arisen through gene duplication during evolution and plays an essential role in cardiovascular and body fluid homeostasis. ANP and BNP bind mainly to NPR-A, while CNP binds specifically to NPR-B. Both NPR-A and NPR-B have guanylyl cyclase catalytic activity and produces intracellular secondary messenger cGMP in response to peptide-ligand binding. Consequently, the NPR-A activation results in vasodilation and inhibition of vascular smooth muscle cell proliferation. NPR-C acts as the receptor for all the three members of NP family, and functions as a clearance receptor. Unlike NPR-A and -B, NPR-C lacks an intracellular guanylyl cyclase domain and is thought to exert biological actions by sequestration of released natriuretic peptides and/or inhibition of adenylyl cyclase.
Statistics
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PSSM-Id: 107368
View PSSM: cd06373
Aligned: 34 rows
Threshold Bit Score: 432.827
Threshold Setting Gi: 115650757
Created: 12-Jul-2007
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:1YKI; Human NPR-C complexed with brain natriuretic peptide, contacts calculated at 3.5 A.
    View structure with Cn3D
  • Structure:1YK0; Human NPR-C complexed with atrial natriuretic peptide, contacts calculated at 3.5 A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
1YK1_A         53 EVLVLLpqdd---------------sylfSLTRVRPAIEYALrsvegngtgrrllppgtrFQVAYEDSdc-------gNR 110
gi 18654149    42 NVIVILpkrest-----------ydnfgmTLQKAMPVIDIAVqevikak-----klppgwINLTYWDSrlyedillaeRH 105
gi 24647268    87 VFVALLpsvesd------------nkndcIMPKVLPVLELAIrhvqrmgf---vggshfdIQLISRDTfc------ssKY 145
gi 24656567    90 NVGVLMashl---------------dspfDLERCGPAVDLALdeinkv------flkphnITLLKKKGsyps---csgAR 145
gi 112983652   45 KLGVLLpadp---------------nqvfSLVKVLPILEMAIpavtkqd----gplpgwkILVDYRDTlc------ssVE 99
gi 115629180  383 NLSVMLpayplpsikgeypwlpegrlfpyHLQMVIPAMRIAVqevtdre-----llpthnITLHVNDThc------siNT 451
gi 115650757  190 HLLMIHgty-----------------glmSYQYNDPAIDIAVeeirrrv----tegeyvnISLTLEDVtirc--fggeRQ 246
gi 115689573   14 TVLLLYafntidnslgi-eiivkglssnyFETTIVPVIDIAVerihtmv----dqgkymnFSIVFHHYsytce-hvypSL 87
gi 115698534    5 LLALLLtgpp----------------hnlNEIHLRPAIDIAFekvnngaa--rglylnfsMSYVFRETgpdc--grpvME 64
gi 156554427   17 KLAVIApadp---------------rheqSLPRLLPAVLMAVravsspk----gplpgwtIEVEHRDSqc------ssTY 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                  ##    #   #                                           #
1YK1_A        111 ALFSLVDRVAAargaKPDLILGPVCEYa--aAPVARLASHWDLPMLSAGA--------------------------LAAG 162
gi 18654149   106 ATVGVIQAYCEh---RLDAILGFADNYglatVTKVTAGLNGGIPILTTSG--------------------------MPSL 156
gi 24647268   146 GPIGFFEIYTQw--pEVNAVFGLPCEYv--lAPISRYADVWQVPVLTTGG--------------------------NAKE 195
gi 24656567   146 APGLAADMYFQd---DVIAFIGPACAFa--lEPVARLAAYWNKPIITGMGdqppssegeltvtsgilgrihkwkneNTGM 220
gi 112983652  100 GPLAAFEFYVNg---SADAFIGPGCEYv--iAPVARYAGPWGIPVLTAGA--------------------------QAEA 148
gi 115629180  452 AQLVSADIFIEh---RVMGFFGPVCEYp--nGPVGRFAAHWNVPQLTTGA--------------------------QASG 500
gi 115650757  247 AGAIFAETYFKr---PLAAIMGPPCSNq--mHSVAELAAAWDIPVLSGLS--------------------------SSRD 295
gi 115689573   88 GASLAAKYYHTk---KVAAFMGPTCNSa--mENVAILCAAWNLPVLSGMS--------------------------PGFM 136
gi 115698534   65 APAIAAELYRRy---SLDGILGSPCSYe--tVGIADLAAYWNLPVVTGVS--------------------------TSAV 113
gi 156554427   72 GPLAAFDFYINr---TADAFLGPVCEYv--lAPVARYAGAWDIPVLTAGG--------------------------QADA 120
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #                                                       #                      #
1YK1_A        163 FqhkdseYSHLTRVAPAYaKMGEMMLALFRhhh------------wsRAALVYSDDKle-----------------rnCY 213
gi 18654149   157 Lnsk-keYPFLTRMQGSYrLLADSMYQLIAyhdedsvsksnsslnylNLIFFYHDKRravnrviaqdesqetgatsshCY 235
gi 24647268   196 FnkksesYSTLTRLKGAQvNNLGNVVRAILnsf-----------nwtRTALIYQNENakvk-------------gnsvCF 251
gi 24656567   221 Fkdk-skYPTLTRMSYCQcRLILVFASVIRqfn------------wnHVALLVDRSEl-------------------fSW 268
gi 112983652  149 FfykhpsYATLTRMMGSYtQAGVAIRNIFEefn------------wrRLGMLYHNNGpssgk------------gnspCF 204
gi 115629180  501 Ysvt-pyDKTLTNMMPPHsKMGDFVGQVFQkye------------wtRAVFLYHDGNnyi---------------rdmMF 552
gi 115650757  296 Lene-aiYSTLTRTTQIIaSGYAYAIVEVLrhf-----------gwgVASVIWDGGIn--------------------YW 343
gi 115689573  137 Lgdk-dkFHTLTRTSSLAeHFARAVEAAMHyfn------------whMIIWINQSEEg-------------------yFG 184
gi 115698534  114 Lddk-srYRTLTRTSFKTgVLAKAVVAFFEeye------------wrQFALVWQYPGy-------------------sSL 161
gi 156554427  121 FrhkdehYPTLTRMMGSHrLVGEALQHILQgfg------------wkVAALLFHNHAmassr------------gnskCH 176
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #  #  ##                  #                                                     
1YK1_A        214 FTLEGVHEVf--------qEEGLHTSIYSFdetk---dldlEDIVRNIQASerVVIMCassDTIRSIMLVAHRHgmt-sg 281
gi 18654149   236 FSLYAIKRYfteksktfkrEWALNTPQFPFdedlvieretfKQWLREISLQsnVIILCaspDTVREIMLAAHDLgmatsg 315
gi 24647268   252 LCLAAIHDT----------IEEHSVYQLGFdtstw-tkadiTRMLKNVAMQsrIVIMCadpQSIRQIMLTAEELnmidsg 320
gi 24656567   269 TVGKNLEYGl---------RQEGLLSFVKElngne--eevyENYLKDASMYarVVILSvrgVLVRKFMLAAHSLgmt-ng 336
gi 112983652  205 LTLSAVFTVlnk-----ktSGSDNIITAQFdetnt-tntkfKELLHKLSLStrIVVLCanpATVREIMLAADDLnmvssg 278
gi 115629180  553 MAGSVFGIVr--------gGFNMNVTNEDFdeyvp-nldygDLLQRTASPYarVVIICasgDAVRKLMLAAHRLgmt-dg 622
gi 115650757  344 SLIEEAATRel-------dRIEFDYHDFSMrai-----sdnFLALLNASKVgrIIFMAvdgDTLREIMLHAYDLdli-ng 410
gi 115689573  185 AITEGLRDHh--------aELFKEGFDFVEikswe--fddtKDILVHAMTKgrVLFLAvdgDTLRSIMLNAYDLdll-ng 253
gi 115698534  162 IAIAMKELMe--------tQENVTMYEFDLrdy-----gsiKDALDAAAAVsrIIILSaqgELVREAMLHAFDTglv-dg 227
gi 156554427  177 FTLGAVYTA----------LNQTSMYKSFNqedst--andyRNLLTFVSKSarIVVMCanaTTIREILLAAEELgmvdsg 244
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
1YK1_A        282 dYAFFNIELFNsssygdgswk-----rgdkhdfeaKQAYSSLQTVTLlrtvkpEFEKFSMEVKSSVekqg-----lnmED 351
gi 18654149   316 eYVFINIDVSTgshaeqpwira--ndtnneenekpKEAYRALKTISLrrsdldEYKNFELRVKERAdqkynytnitgkDY 393
gi 24647268   321 eYVFINIELFSrvqyltsqpwyd-kndtdlnneraQKAYTAMLTVTPkqpndnEYTRVSNEIKAIAaekyn--ytfsdNE 397
gi 24656567   337 eWVFLDVEIFQseywgdkgwe-----mkdehdakaRKAYEALLRVSLlqptspKFQDFADNVRENAlydyn--ytfgeGE 409
gi 112983652  279 eYVFFNIELFSnlasasskepwksendteerneraRRAYSAVLTVTSpapekkEYLEFSDQVKELAatkyn--ytfgkGE 356
gi 115629180  623 sYAFFNIVLFDssyfgnigwe-----rgdaddenaKAAYRALMTFTLhkkkspVFEEFALDVKERAlkef----nfsyDA 693
gi 115650757  411 dYAFINIIPFRdeqlfgddsw----ergdnrdeeaKVAYQALMTIRVfeptseAYREFEENVRERQkrdfn--itdsgAG 484
gi 115689573  254 dYAFINIIPFRdidifgndsw----ergdgrddqaKKAYEALMTIRVfeptssVYKDFENEVILRRemnyni-tmdhdRS 328
gi 115698534  228 eYAFVSIEPFSntlvfgddnw----kqndgrdddaKKAYESLLIFRLfkpqtdEYRAFQRELERREildyn--wtrpdPD 301
gi 156554427  245 eYVFFSIELTSsdnstkepwrv--vgdtpernekaRKAYQALLTVTTrtpdnvEYLNFSREVKSLAqsryn---ftfgNS 319
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
1YK1_A        352 YVNMFVEGFHDAILLYVLALHEVLRAGys----kkDGGKIIQqTWNRTFEGIAGQVSIDaNGDRYGDFSVIAMtdveagT 427
gi 18654149   394 EMNNFISAFYDAVLLYAIALNETIQSGld----prNGHNITSrMWGRTFVGITGNVSIDhNGDRYSDYSLLDLdpvqnrF 469
gi 24647268   398 PISAFVTSFFDGVLLYANALNESIREDptmltrpiNGTDMVRrMWNRSFTGITGNVTIDaNGDRLSAYSLLDMnpttgrF 477
gi 24656567   410 EVNFFIGAFYDGVYLLGMALNETLTEGgd----irDGVNITRrMWNRTFEGITGHVRIDdNGDRDADYSILDLdpingkF 485
gi 112983652  357 VVSTFVAAFYDAVLLYALALNDTLQQAtdpr-gqlDGAAVMRnMWNRTFQGITGEVVINsNGDRVASYSLLDMnpn-tsK 434
gi 115629180  694 IGEEVVGIYYGAKRLYEPVPGKTIDWPgt-----vIPPDTPKcGFENELCPATDNSPMTlWIMGAMAIIILSAvviilfV 768
gi 115650757  485 SNIFLASAFYDVMILYSLAINETIAEGgd----vyDGHAVTKkMWNRTFDDTENGTFEVvGNFYLTSSGLKYTpvpgkpI 560
gi 115689573  329 SHIFLASAFYDIMILYSLAINETLAEGgd----vyDGHAVTNrMWNRTFEGLYGQVVINeNGDRDSEYTLWDMtdtengT 404
gi 115698534  302 HNNYFASAFHDAVILYSLAVNETLAEGgn----isDGYVITRkMWGRSFQGISGTVTINeNGDRSGDYSLWDMtntedgT 377
gi 156554427  320 SVSTFVTAFYDAVLLYALALKESLPDKpge--vnlDGGNLTRrMWGRSFKGITGYVHIDeNGDRIADYSLLDMnpe-tsK 396
                         490
                  ....*....|....*..
Feature 1                          
1YK1_A        428 QEVIGDYFgkegRFEMR 444
gi 18654149   470 VEVAYYSGasnqLKTVG 486
gi 24647268   478 EIVAHFLHnrleFEANK 494
gi 24656567   486 SVVAHYSGvhkqMKLSK 502
gi 112983652  435 FEVVATYVaankTLQFT 451
gi 115629180  769 LRKYRLERelsnMSWRI 785
gi 115650757  561 KWPGGATSpprdTPFCG 577
gi 115689573  405 FEIVGNFYvaasGLRYT 421
gi 115698534  378 FEVLANYYgetgVIETT 394
gi 156554427  397 FEIVANYYgankTLEYI 413

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