Conserved Protein Domain Family
PBP1_mGluR_groupI

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cd06374: PBP1_mGluR_groupI 
Click on image for an interactive view with Cn3D
Ligand binding domain of the group I metabotropic glutamate receptor
Ligand binding domain of the group I metabotropic glutamate receptor, a family containing mGlu1R and mGlu5R, all of which stimulate phospholipase C (PLC) hydrolysis. The metabotropic glutamate receptor is a member of the family C of G-protein-coupled receptors that transduce extracellular signals into G-protein activation and ultimately into intracellular responses. The mGluRs are classified into three groups which comprise eight subtypes.
Statistics
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PSSM-Id: 107369
View PSSM: cd06374
Aligned: 5 rows
Threshold Bit Score: 842.25
Threshold Setting Gi: 71986185
Created: 4-Jun-2007
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
ligand bindingdimerization
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:1EWK; Rattus norvegicus mGluR subtype I binds glutamate, contacts calculated at 3.5 A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                               #                                         
1EWK_A          4 RSVARMDGDVIIGALFSVHHQppaekvperkCGEIREQYGIQRVEAMFHTLDKINadpvllPNITLGSEIRDSCWHsSVA 83
gi 62297775    36 RSVARMDGDVIIGALFSVHHQppaekvperkCGEIREQYGIQRVEAMFHTLDKINadpvllPNITLGSEIRDSCWHsSVA 115
gi 113679932   45 RSVARMDGDVIIGALFSVHHQpsaervadrkCGDVREQYGIQRVEAMFHTLDRINadqnllPNITLGCEIRDSCWHsSVA 124
gi 46049084    32 RVVAHMPGDIIIGALFSVHHQptvdkvherkCGEVREQYGIQRVEAMLHTLDRINldptllPNITLGCEIRDSCWHsAVA 111
gi 71986185    28 MLVAEIHGEIQIGALFPIHRQiag----sesCGEIWEQYGIQRSEIAMLTVKQLNe----eLPFKLGLSIRDSCWTeRIA 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                          #                    ###       
1EWK_A         84 LEQSIEFIRdslisirdekdglnrclpdgqtlppgrtkkPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDK 163
gi 62297775   116 LEQSIEFIRdslisirdekdginrclpdgqslppgrtkkPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDK 195
gi 113679932  125 LEQSIEFIRdslisirddkdgskwcidgtpsnqpppskkPIAGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSIDLSDK 204
gi 46049084   112 LEQSIEFIRdslisseeeegmvr---cvdgssssfhskkPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDK 188
gi 71986185   100 MEQTIAFLRegvaqcsccq-----------tpgcnkksvPVVAVIGPGKSSSTIAVQNLLQVFRIPQVGYSATTPDLSDK 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                 #                                       
1EWK_A        164 TlYKYFLRVVPSDTLQARAMLDIVKrYNWTYVSAVHTEGNYGESGMDAFKELAAQEg--LCIAHSDKIysnageksFDRL 241
gi 62297775   196 TlYKYFLRVVPSDTLQARAMLDIVKrYNWTYVSAVHTEGNYGESGMDAFKELAAQEg--LCIAHSDKIysnageksFDRL 273
gi 113679932  205 TlFKYFLRVVPSDTLQARAMLDIVKhYNWTYVSAVHTEGNYGESGMEAFKELAAEEg--LCIAHSDKIysnagekhFDRL 282
gi 46049084   189 TlFKYFMRVVPSDAQQARAMVDIVKrYNWTYVSAVHTEGNYGESGMEAFKDMAAKEg--ICIAHSYKIysnageqsFDKL 266
gi 71986185   169 EqFGYFLRVVPSDVFQAQAINRLLHhYNWTYVAVLYSAGNYGEKGFESLEKLIAHRsssVCIAYSEKIktlaseqeYRQV 248
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                         #                               
1EWK_A        242 LRKLRERlpkarVVVCFCEGmTVRGLLSAMRRLgvv----geFSLIGSDGWADRDEViegyEVEANGGITIKLqspeVRS 317
gi 62297775   274 LRKLRERlpkarVVVCFCEGmTVRGLLSAMRRLgvv----geFSLIGSDGWADRDEViegyEVEANGGITIKLqspeVRS 349
gi 113679932  283 LKKLRERlpkarVVVCFCEGmTVRSLLMAMRRRgvs----geFQLIGSDGWADRDEVvegyEQEADGGITMKLqteeVQS 358
gi 46049084   267 LRKLRSHlpkarVVACFCEGmTVRGLLMAMRRLgla----geFLLLGSDGWADRYDVtdgyQREAVGGITIKLqspdVKW 342
gi 71986185   249 LTRLDSQnsrpqVVVCFCEGaSMRMFFKAQKHLadgkmqmkrFQWIGSDGWADRNDVvedlEEEAEGSFSIRIhapkIPG 328
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                     #                   
1EWK_A        318 FDDYFLKLrldtNTRNPWFPEFWQHRFQCrlpghlle-npnfkkvCTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMH 396
gi 62297775   350 FDDYFLKLrldtNTRNPWFPEFWQHRFQCrlpghlle-npnfkriCTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMH 428
gi 113679932  359 FNDYFLKLrldtNKRNPWFAEFWQYRFQCripghpqe-nhnyqkiCTGNESLKDNYVQDSKMGFVINAIYAMAHGLHDMH 437
gi 46049084   343 FDDYYLELrpetNHRNPWFQEFWQHRFQCrlegfpqe-npkynktCTSQMTLRTQHVQDSKMGFVINAIYSMAYGLHNMQ 421
gi 71986185   329 FRQYYTALhpenNTMNPWFREFWQQKFNCqfavskedknneniriCSGDENLDEQYKEDPKLSQVINSIRVVALGLKAMY 408
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
1EWK_A        397 HALCpghvglCDAMKPIDGRKLLDFLikssfvgvsGEEVWFDEKGDAPGRYDIMNLqyte-anryDYVHVGTWHEg-VLN 474
gi 62297775   429 HALCpghvglCDAMKPIDGSKLLDFLikssfigvsGEEVWFDEKGDAPGRYDIMNLqyte-anryDYVHVGTWHEg-VLN 506
gi 113679932  438 REMCpehsglCEAMDPIDGSKLLDYLlktsfsgvsGEEIYFDVNGDSPGRYDIMNLqyveeigrfDYINVGSWHEg-LLS 516
gi 46049084   422 LSLCpgyvglCDAMKPIDGRKLLESLmktnftgvsGDMILFDENGDSPGRYEIMNFkkmg-kdyfDYINVGSWDNg-ELK 499
gi 71986185   409 QDRCrdnstlCTEMLSRNGTLLYEYLlnvtysdqfKQPVYFDRNGDPPAWYDILNYigtk-dldnPYNEVGSFKSinDYG 487

                  ....
Feature 1             
1EWK_A        475 IDDY 478
gi 62297775   507 IDDY 510
gi 113679932  517 ISDY 520
gi 46049084   500 MDDD 503
gi 71986185   488 VEEL 491

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