Conserved Protein Domain Family
PBP1_mGluR_groupII

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cd06375: PBP1_mGluR_groupII 
Click on image for an interactive view with Cn3D
Ligand binding domain of the group II metabotropic glutamate receptor
Ligand binding domain of the group II metabotropic glutamate receptor, a family that contains mGlu2R and mGlu3R, all of which inhibit adenylyl cyclase. The metabotropic glutamate receptor is a member of the family C of G-protein-coupled receptors that transduce extracellular signals into G-protein activation and ultimately into intracellular responses. The mGluRs are classified into three groups which comprise eight subtypes
Statistics
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PSSM-Id: 107370
View PSSM: cd06375
Aligned: 8 rows
Threshold Bit Score: 855.22
Threshold Setting Gi: 1834427
Created: 6-Jun-2007
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
ligand-bindingdimerization
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand-binding site [chemical binding site]
Evidence:
  • Structure:2E4U; Rattus norvegicus mGuR subtype II complexed with glutamate, contacts calculated at 3.5 A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                          #                                              
2E4U_A         13 GDLVLGGLFPINEKGtgt------eeCGRINEDRGIQRLEAMLFAIDEINkdnyLLPGVKLGVHILDTCSRDTYALEQSL 86
gi 68369404    37 GDLVIGGLFPVHEKGkgt------edCGKINEERGIQRLEAMLLALDEINqdnrILPGLKLGAHILDTCSKDTYALEQSL 110
gi 1834427     43 GDIILGGLFPVHEKGeg-------apCGPKVYNRGVQRLEAMLYAIDRVNndpnILPGITIGVHILDTCSRDTYALNQSL 115
gi 115923310  601 GDLMIGGLFPIHEKGsqnvgsldderCGLINEDRGIQRVEAMLFAIDKINndstILPGIRLGASLRDTCSIDTFALEQSL 680
gi 76803802    30 GDLVLGGLFPVHQKGgpa------edCGPVNEHRGIQRLEAMLFALDRINrdphLLPGVRLGAHILDSCSKDTHALEQAL 103
gi 118082020   37 GDLVLGGLFPINEKGtgi------eeCGRINEDRGIQRLEAMLFAIDEINrdnyLLPGIKLGVHILDTCSRDTYALEQSL 110
gi 91076048    39 GDIILGGLFPVHKKGer-------taCSQQIYHRGVQRLEAMMFAIDRINsnprILPNITLGVHILDTCSRDTYALNQSL 111
gi 126632563   31 GDLVLGGLFPIHEKGmgm------deCGRINEDRGIQRLEAMLFAIDQINqdvaLLPGVVLGVHILDTCSRDTYALEQAL 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                   #                    ###              
2E4U_A         87 EFVRASLtkvdeaeymcpd--gsyaiqeniplLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFA 164
gi 68369404   111 AFVRASLtkvhqpgficpd--gsnpvpdelplAISGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFA 188
gi 1834427    116 QFVRASLnnldtsgyecadgsspqlrknassgPVFGVIGGSYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFA 195
gi 115923310  681 EFVRVSLttsnpadclnk----stivastsagSVAGVIGGSYSTVSMQVANLLRLFEIPQISYASTSARLSDKSRFEFFA 756
gi 76803802   104 DFVRASLsrgadgsrhicp-dgsyathgdaptAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFA 182
gi 118082020  111 EFVRASLtkvdeteymcpd--gsyaiqenlplLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFA 188
gi 91076048   112 QFVRASVnnidtsalecvd-hsiprprnnytgPVFGVVGGSYSSVSLQVANLLGLFHIPQISPASTAKALSDKTRFEYFA 190
gi 126632563  105 EFVRASLtkvddteficpd--gsyalqedsplAIAGVIGGSFSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFA 182
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                          #                                              
2E4U_A        165 RTVPPDFYQAKAMAEILRfFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVgrsn-irksYDSVIRELLQKP 243
gi 68369404   189 RTVPPDFYQAKAIAEILRyFNWTYVSTVASEGDYGETGIDAFQQEARVRQICIATSVKVsrsv-nqgnYETVIRSLQQKA 267
gi 1834427    196 RTVPPDTFQSVALVDILKnFNWSYVSTIHSEGSYGEYGIEALHKEATERNVCIAVAEKVpsaa-ddkvFDSIISKLQKKP 274
gi 115923310  757 RTVPPDTLQAKAIADILShFNWTYVSTVWSSGEYGESGMDQFEKERLHRNICIAASEKIpysp-damtYDIIISRLIKKK 835
gi 76803802   183 RTVPPDFFQAKAMAEILRfFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVgram-sraaFEGVVRALLQKP 261
gi 118082020  189 RTVPPDFYQAKAMAEILRfFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATSEKVgrsn-irksYDGVIRELLQKP 267
gi 91076048   191 RTVPPDTFQSSALVDIVKsVNWSYVSTIYSEGSYGEYGIEVFHREAQERNVCIATAEKVpsta-ddhaFDNIIMKLKKKV 269
gi 126632563  183 RTVPPDFYQAKAMAEILRaFNWTYVSTVASEGDYGETGIEAFEQQARLRNICIATSEKVgrssakrssYEAVVRQLLQKP 262
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                            #                                            
2E4U_A        244 NARVVVLFmRSDDSRELIAAANRVNAS--FTWVASDGWGAQESIVkgsEHVAYGAITLELashpVRQFDRYFQSLNPYNN 321
gi 68369404   268 NAKVVILFtRSEDARELLAAAARMNVT--FIWVASDGWGAQESVVhdsEKAANGAFTIELasysIREFEDYFTKLTPELN 345
gi 1834427    275 NARGVVLFtRAEDARRILQAAKRANLSqpFHWIASDGWGKQQKLLeglEDIAEGAITVELqseiIADFDRYMMQLTPETN 354
gi 115923310  836 AAKVVVLFtRDVDARDLLEAALRVNASkkFIWVASDGWGVQDTPVngrETVAEGAITIELqtkkIKGFDQYFRGINPRTN 915
gi 76803802   262 SARVAVLFtRSEDARELLAASQRLNAS--FTWVASDGWGALESVVagsEGAAEGAITIELasypISDFASYFQSLDPWNN 339
gi 118082020  268 NARVVVLFmRGDDSRELIAAANRFNVS--FTWIASDGWGAQESIVkgnEHIASGAITLELashpVKEFDRYFQSLSPYNN 345
gi 91076048   270 NARGVVLFtRAEDARRILQAAKRLNAShtFYWVASDGWGKQQKLVeglEDVAEGAITVELqsdnIPGFDEYMMSLTPETN 349
gi 126632563  263 TARVAVLFlRSDDARELIAAAARLNAS--FLWVASDGWGAQESIVkgnEFTADGAITLELaahpIPDFNRYFQTLTPQIN 340
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                       #                 
2E4U_A        322 HRNPWFRDFWEQKFQCSLqnkrnhrqvc-------------------dkhlaidssnYEQESKIMFVVNAVYAMAHALHK 382
gi 68369404   346 TRNPWFREYWEHNFGCNLqdhgcas-------------------------kslrndlFKPESKIMFVVNAVYAMAYALHN 400
gi 1834427    355 QRNPWFAEYWEDTFNCVLtslsvkpdtsnsanstdnkigvkaktecddsyrlsekvgYEQESKTQFVVDAVYAFAYALHN 434
gi 115923310  916 TRNPWFKDFWEQKFQCLLepgdsvntstp------------------caenvldeanHAQEKKTQFVVDAVFAMAHALHT 977
gi 76803802   340 SRNPWFREFWEQRFRCSFrqrdcaa-------------------------hslravpFEQESKIMFVVNAVYAMAHALHN 394
gi 118082020  346 RRNPWFKDFWEQKFQCNLqnrkphkktc-------------------dkhftinssnYEQESKIMFVVNAVYAMAHALHK 406
gi 91076048   350 LRNPWFEQYWEDTFDCILeknvplithtnfn-------------vckpelrlsqkvgYEQESKVQFVVDAVYAFALALHN 416
gi 126632563  341 HRNPWFKDFWEQKFQCSLggtsatgagtpkp--------------pcdqelvidksnFEPESKIMFVVNAVYAMAHALHR 406
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
2E4U_A        383 MQRTLCPqtt--------------------------klCDAMKILDGKKLYKEYLLKiqftapfnpnkgaDSIVKFDTFG 436
gi 68369404   401 MRQAVCPntt--------------------------kvCDAMKPGNGKRFYREFILKtkfdap-frpadtENVVRFTSLG 453
gi 1834427    435 LHNDRCNtqsdqttetrkhlqsesvwyrkistdtksqaCPDMANYDGKEFYNNYLLNvsfi------dlaGSEVKFDRQG 508
gi 115923310  978 MQTDMCPhte--------------------------elCDNMLPIDGRKLFKEYILNttfv------dlaDTEVSFDSQG 1025
gi 76803802   395 MHRALCPntt--------------------------rlCDAMRPVNGRRLYKDFVLNvkfdap-frpadtHNEVRFDRFG 447
gi 118082020  407 MQRTLCPntt--------------------------klCDAMKHLDGKKLYKDYLLKvnftapfnppnaaDSTVKFDAYG 460
gi 91076048   417 LYRDLCKdyrk------------------------sgvCPAMTQYDGGDFYKKYLLNvsft------dlaGSPVKFDHRG 466
gi 126632563  407 MQRTLCAntt--------------------------rlCDAMRSLDGRKLYRDFLLHvnfrap-fspaglESQVKFDAYG 459
                         490       500       510
                  ....*....|....*....|....*....|....
Feature 1                                           
2E4U_A        437 DGMGRYNVFNLqqtggkysYLKVGHWaETLSLDV 470
gi 68369404   454 DSLGRYNIFHYrkednkyvYRKVGYWaQGLVLNT 487
gi 1834427    509 DGLARYDILNYqrqenssgYQYKVIGkWFNGLQL 542
gi 115923310 1026 DGLGRYDVMNYrpiegtddYRYVKVGeWANILSM 1059
gi 76803802   448 DGIGRYNIFTYlrag-sgrYRYQKVGyWAEGLTL 480
gi 118082020  461 DGIGRYNVFNFqytgdrysYVKVGHWaETLSLEV 494
gi 91076048   467 DGLARYDILNYqrlinasgYHYRVVGkWFNSLEL 500
gi 126632563  460 DGVGRYNIFNYqsvpgsdkFAYVQVGeWAESLSL 493

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