Conserved Protein Domain Family
PBP1_mGluR_groupIII

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cd06376: PBP1_mGluR_groupIII 
Click on image for an interactive view with Cn3D
Ligand-binding domain of the group III metabotropic glutamate receptor
Ligand-binding domain of the group III metabotropic glutamate receptor, a family which contains mGlu4R, mGluR6R, mGluR7, and mGluR8; all of which inhibit adenylyl cyclase. The metabotropic glutamate receptor is a member of the family C of G-protein-coupled receptors that transduce extracellular signals into G-protein activation and ultimately into intracellular responses. The mGluRs are classified into three groups which comprise eight subtypes.
Statistics
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PSSM-Id: 107371
View PSSM: cd06376
Aligned: 6 rows
Threshold Bit Score: 942.393
Threshold Setting Gi: 3024134
Created: 6-Jun-2007
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
ligand-bindingdimerization
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand-binding site [chemical binding site]
Evidence:
  • Structure:2E4Z; Rattus norvegicus mGluR subtype III complexed with 2-morpholin-4-ylethanesulfonic acid, contacts calculated at 3.5 A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                   #                                                    
2E4Z_A        15 GDVTLGGLFPVHAKGpsgvPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQal 94
gi 3024134    37 GGLTLGGLFPVHARGaagrACGPLKKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQal 116
gi 118097083  44 GDITLGGLFPVHAKGppgvPCGDIKKENGIHRLEAMLYALDQINSDPELLPNVTLGARILDTCSRDTYALEQSLTFVQal 123
gi 121583804  58 GDITLGGLFPVHSRGpagiPCGEVKKEKGIHRMEAMLYALDQINSDPDLLPNITLGARILDTCSRDTYALEQSLTFVQal 137
gi 163914977  43 GDITLGGLFPVHSRGlpgmPCGDIRKENGIHRLEAMLYALDQINSDPDILPNVTLGARILDTCSRDTYALEQSLTFVQal 122
gi 12644040   44 GDIILGGLFPVHAKGergvPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQal 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                             #                    ###                   
2E4Z_A        95 iqk----dtsdVRCTNGEPPVFv-kPEKVVGVIGASgSSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPP 169
gi 3024134   117 irgrgdgdevgVRCPGGVPPLRpapPERVVAVVGASaSSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPP 196
gi 118097083 124 iqk----dtsdVRCTNGEPPVFv-kPEKVVGVIGASgSSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPP 198
gi 121583804 138 iqk----dnsdVRCSNGEPPIIp-kPERVVGVIGASaSSVSIMVANVLRLFAIPQISYASTAPELSDNNRYDFFSRVVPP 212
gi 163914977 123 iqk----dtsdVRCTNGDPPVFv-kPEKVVGVIGASeSSVSIMVANILRLFQIPQISYGSTAPELSDDRRYDFFSRVVPP 197
gi 12644040  124 iek----dasdVKCANGDPPIFt-kPDKISGVIGAAaSSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPP 198
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                    #                                                   
2E4Z_A       170 DSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAggLCIAQSVRIpqerkdrtidFDRIIKQLLDTpNSR 249
gi 3024134   197 DSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAggVCIAQSIKIprep--kpgeFSKVIRRLMETpNAR 274
gi 118097083 199 DSFQAQAMVDIVKALGWNYVSTLASEGNYGEKGVESFMQISREAggLCIAQSLKIpqdrkdktidFDKIIKQLLETpNAR 278
gi 121583804 213 DSFQAQAMVDIVKAMGWNYVSTLASEGNYGESGVDAFIQISREAggLCIAQAIKIprep--rpgeFDKIIKRLMETsNAR 290
gi 163914977 198 DSFQAQAMVDIVKAMGWNYVSTLASEGSYGEKGVESFMQISREAggVCIAQSLKIpyer--ttsdFDKIIKQLLETsSAR 275
gi 12644040  199 DSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIggVCIAQSQKIprep--rpgeFEKIIKRLLETpNAR 276
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                         #                                              
2E4Z_A       250 AVVIFa-NDEDIKQILAAAKRAdqvGHFLWVGSDSWGSKINPlhqhEDIAEGAITIQPKRATVEGFDAYFTSRTLeNNRR 328
gi 3024134   275 GIIIFa-NEDDIRRVLEAARQAnltGHFLWVGSDSWGAKTSPilslEDVAVGAITILPKRASIDGFDQYFMTRSLeNNRR 353
gi 118097083 279 AIVIFa-NDEDIKQILAAAKRAdqvGHFLWVGSDTWGSKVSPllqqEDVAEGAITILPKRATIEGFDAYFTSRTLeNNRR 357
gi 121583804 291 GVIIFa-NEDDIKRVLEAAKRAnltGHFLFVGSDSWGAKISPilnqEDVAEGAVTILPKRASIEGFDQYFTTRSLeNNRR 369
gi 163914977 276 AVVLFavDDDDIRQVLSAVKRAdkvGHFHWVGSDTWGAKVGPiiqnEDVAEGAITILPKRATIEGFDAYFTSRTLeNNRR 355
gi 12644040  277 AVIMFa-NEDDIRRILEAAKKLnqsGHFLWIGSDSWGSKIAPvyqqEEIAEGAVTILPKRASIDGFDRYFRSRTLaNNRR 355
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                      #                                 
2E4Z_A       329 NVWFAEYWEENFNCKLtisgskkedtDRKCTGQERIgkdsnYEQEGKVQFVIDAVYAMAHALHHMNKDLCadyrGVCPEM 408
gi 3024134   354 NIWFAEFWEENFNCKLtssgtqsddsTRKCTGEERIgrdstYEQEGKVQFVIDAVYAIAHALHSMHQALCpghtGLCPAM 433
gi 118097083 358 NVWFAEYWEENFNCKLtitgskkedtDRKCTGQERIgkdshYEQEGKVQFVIDAVYAMAHALHHMSKDLCadyaGVCPEM 437
gi 121583804 370 NIWFAEFWEDDFKCKLtrpgirgdggLRKCTGEERIgrdsgYEQEGKVQFVIDAVYAMAHALHSMHIDLCpgsmGVCDKM 449
gi 163914977 356 NVWFAEFWEENFNCKLtitgskkedtDRKCTGQERIgqdslYEQDERVQFVVDAVYAMAHALHNMNKDLCpgstGICPEM 435
gi 12644040  356 NVWFAEFWEENFGCKLgshgk-rnshIKKCTGLERIardssYEQEGKVQFVIDAVYSMAYALHNMHKDLCpgyiGLCPRM 434
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
Feature 1                                                                                 
2E4Z_A       409 EqagGKKLLKYIRHVNFNGSAgtPVMFNKNGDAPGRYDIFQYQttnt--tnpgYRLIGQWTDELQLNIEDMQW 479
gi 3024134   434 EptdGRMLLQYIRAVRFNGSAgtPVMFNENGDAPGRYDIFQYQatngsassggYQAVGQWAETLRLDVEALQW 506
gi 118097083 438 EhagGKKLLKYIRSVNFNGSAgtPVMFNKNGDAPGRYDIFQYHttnt--stpgYRLVGQWTDDLQLNIDDMQW 508
gi 121583804 450 DpvdGRMLLTYIRAVNFNGSAgtGVMFNENGDAPGRYDIFQYQlsnt--tnpgYKLIGQWTNHLRLSAEDMQW 520
gi 163914977 436 EhagGKKLLKYIRNVSFNGSAgtPVMFNKNGDALGRYDLFQYQitng--stqgYRLIGQWTDELQLNIEDMQW 506
gi 12644040  435 StidGKELLGYIRAVNFNGSAgtPVTFNENGDAPGRYDIFQYQitnk---steYKVIGHWTNQLHLKVEDMQW 504

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