Conserved Protein Domain Family
PBP1_iGluR_NMDA_NR3

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cd06377: PBP1_iGluR_NMDA_NR3 
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR3 subunit of NMDA receptor family
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR3 subunit of NMDA receptor family. The ionotropic N-methyl-d-asparate (NMDA) subtype of glutamate receptor serves critical functions in neuronal development, functioning, and degeneration in the mammalian central nervous system. The functional NMDA receptor is a heterotetramer composed of two NR1 and two NR2 (A, B, C, and D) or of NR3 (A and B) subunits. The receptor controls a cation channel that is highly permeable to monovalent ions and calcium and exhibits voltage-dependent inhibition by magnesium. Dual agonists, glutamate and glycine, are required for efficient activation of the NMDA receptor. Among NMDA receptor subtypes, the NR2B subunit containing receptors appear particularly important for pain perception; thus NR2B-selective antagonists may be useful in the treatment of chronic pain.
Statistics
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PSSM-Id: 107372
View PSSM: cd06377
Aligned: 6 rows
Threshold Bit Score: 518.2
Threshold Setting Gi: 47211789
Created: 11-May-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative
Feature 1:putative dimerization interface [polypeptide binding site]
Evidence:
  • Comment:based on sequence similarity to mGluR

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 46277636    19 SAGGRPQPCGVLARLGGSVRLGALMp------------------------------------------------------ 44
gi 20376816    21 VVRGHPQPCRVPTRAGASVRLAALLp------------------------------------------------------ 46
gi 51701684    30 SSSSHPQPCQILKRIGHAVRVGAVHlqpwttapraasrapddsragaqrdepepgtrrspapspgarwlgstlhgrgppg 109
gi 118104429   30 YIAGPGVSTSCLERGSGVAAAPRGEvaagardqrp--------------------------------------------- 64
gi 125830202   29 PAHSHPQPCHILARIGHTVRLGALL------------------------------------------------------- 53
gi 47211789     8 CARSHPQPCQVLKRIGHTVRVGVLHvhprplpgpegwdaepplpglgasghdglr------tgssasgprgssrdqnrar 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                  # ##  #
gi 46277636    45 ----------rAPLARARARAALARaal------aprLPHNLSLELVVaa-----------------ppARDPASLTRGL 91
gi 20376816    47 ----------rAPAARARVLAALATpa--------prLPHNLSLELVAva-----------------spTRDPASLARGL 91
gi 51701684   110 srkpgegaraeALWPRDALLFAVDNlnrv-----eglLPYNLSLEVVMaieaglgdlpllpfsspsspwSSDPFSFLQSV 184
gi 118104429   65 -vgvgerrpgpAPSPRDAILLAVANlngv-----agmLPYNLSLEVVMaieagladlplfpfsspsaswSNDPVSFLQSL 138
gi 125830202   54 -----------PPRQSVRVRAALHRalsglaesgnnfLPYNLSLDVVAre-----------------aqSGDPESLFRCV 105
gi 47211789    82 rregnaaresrVFAPRDSVLAAVEAvnr------aelLPFNLSLEAVVavgsglgglpaspsssaggaePEDPLSFVESV 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #                              #                                                
gi 46277636    92 CQALVPPGVAALLAFPEARpellqLHFLAAATETPVLSLLRrearaplgapnpFHLQLHWASPLETLLDVLAAVLQaHAW 171
gi 20376816    92 CQVLAPPGVVASIAFPEARpelrlLQFLAAATETPVVSVLRrevrtalgaptpFHLQLDWASPLETILDVLVSLVRaHAW 171
gi 51701684   185 CHTVVVQGVSALLAFPQSQgemmeLDLVSLVLHIPVISIVRhefpr--esqnpLHLQLSLENSLSSDADVTVSILTmNNW 262
gi 118104429  139 CHTVVVQGVSAILAFPQTRgemleLDFVSAALRIPVVSIVLgefpr--rspnpLHLQMSLENSLSSDADITFSILAmNNW 216
gi 125830202  106 CQDIVVQGVSAVLAFPQTQeeivqMEFMSSFLEIPFISIIEhgepl--ktqnrFHLQMTTRIPPSGLVELLLAVLQrSGW 183
gi 47211789   156 CHSVVVQGVSAMLAFPRNRdefvkLDFVSQALQVPVVSVVRreftr--hsqnwLHLQMPMVPVAAEAEPLLLWLLMrNGW 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                          #  #                  # #                                      
gi 46277636   172 EDVGLALCRTq-DPGGLVTLWTSRAg-------rPPQLVLDLSRRdt---------gdAGLRARLAPMAAPvggeapvpA 234
gi 20376816   172 EDIALVLCRVr-DPGSLVTLWTNHAs-------qAPKFVLDLSRLds---------rnDSLRAGLALLGALegggtpvpA 234
gi 51701684   263 YNFSLLLCQEdwNITDFLLLTQNNSk-------fHLGSIINITANlpst-----qdllSFLQIQLESIKNSt------pT 324
gi 118104429  217 YNFSLMVCQEewNITDFLFLTQQSSk-------fHLGSIINITANltst-----ndllNYLQFYLESIKDTt------sT 278
gi 125830202  184 EESMAVLCHGw-EDAGLLDLLKLQGrfgwgpsqwHLRAALNLSHStarm-----anisDFLSEHFNLDHSPp------aS 251
gi 47211789   234 WDVRVLLCRNr-DLTSFLLLVRNHTr-------fQLGPLVNLSVAppsssspggrdqqQALLQQLEALRDPpa-----aA 300
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 46277636   235 AVLLGCD------IARARRVLEAVPPG------PHWLLGTPlppkaLPTAGLPPGLLALGEvarppLEAAIHDIVQLVAR 302
gi 20376816   235 AVLLGCS------TARAHEVLEAAPPG------PQWLLGTPlpaeaLPTTGLPPGVLALGEteqhsLEAVVHDMVELVAQ 302
gi 51701684   325 VVMFGCD------MESIRRIFEITTQFgvmppeLRWVLGDSqnmeeLRTEGLPLGLIAHGKttqsvFEHYVQDAMELVAR 398
gi 118104429  279 MVMFGCD------MEKTRRIFEITTRFgvmppeLHWIIGDSqnveeLRTEGLPLGLIAHGKttqsvFEHYVQDAMELVAR 352
gi 125830202  252 VLLFGADpecassVLRSAHDLGLTLPT------VHWIMGHPlspdaLHSIGLPLGLLAYGEvdhkpLDFYISDALQLINR 325
gi 47211789   301 LVTFGCH------VREVRRLWALAARLml--peFHWVLGDGqevggLRAEGLPPGLLAHGLagppsLDQYVQDALELVAR 372
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 46277636   303 ALGSatqvqPKRALLPAPVNCGXlqpag-pespGRFLARFLANTSFQgrTGPVWVTg-SSQVHMSRHLKVWSLRRDPRGA 380
gi 20376816   303 ALSSmalvhPERALLPAVVNCDDlktgg-seatGRTLARFLGNTSFQgrTGAVWVTg-SSQVHVSRHFKVWSLRRDPLGA 380
gi 51701684   399 AVATatmiqPELALIPSTMNCMEvett--nltsGQYLSRFLANTTFRglSGSIRVKg-STIVSSENNFFIWNLQHDPMGK 475
gi 118104429  353 AVAAatmiqPELALIPSTMNCMDtdek--nitsGQYLSKFLANTSFDglSGHIKVKg-SSVVSSENNFFIWNLQHDPVGN 429
gi 125830202  326 AVTAatvvrPDLALIQNMVNCFDkpnkhelpssGQYIARFLSNTSFVglTGPVIVQrnLSRVHTSHKVHIWSLRRDAVGQ 405
gi 47211789   373 AVGSaaladAALALSPATTDCLEerrg--rgssGMYLSRFLSNTSFDgrSGFVSAGggAGALLSEARHYVWSLQLDPLGQ 450
                         490       500
                  ....*....|....*....|....*
Feature 1                                  
gi 46277636   381 PAWATVGSWrdgqldlEPGGASAWP 405
gi 20376816   381 PAWATVGSWqdgqldfQPGAAALRV 405
gi 51701684   476 PMWTRLGSWqg---rkIVMDYGIWP 497
gi 118104429  430 PMWTRLGSWqe---gkIVMDYGIWP 451
gi 125830202  406 PTWVTVGSWegg--rlNVEEQGLWQ 428
gi 47211789   451 PTWTRMGRWrr---gkVVMDQGAWP 472

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