Conserved Protein Domain Family
PBP1_iGluR_NMDA_NR1

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cd06379: PBP1_iGluR_NMDA_NR1 
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor. The ionotropic N-methyl-d-asparate (NMDA) subtype of glutamate receptor serves critical functions in neuronal development, functioning, and degeneration in the mammalian central nervous system. The functional NMDA receptor is a heterotetramer ccomposed of two NR1 and two NR2 (A, B, C, and D) or of NR3 (A and B) subunits. The receptor controls a cation channel that is highly permeable to monovalent ions and calcium and exhibits voltage-dependent inhibition by magnesium. Dual agonists, glutamate and glycine, are required for efficient activation of the NMDA receptor. When co-expressed with NR1, the NR3 subunits form receptors that are activated by glycine alone and therefore can be classified as excitatory glycine receptors. NR1/NR3 receptors are calcium-impermeable and unaffected by ligands acting at the NR2 glutamate-binding site
Statistics
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PSSM-Id: 107374
View PSSM: cd06379
Aligned: 8 rows
Threshold Bit Score: 535.885
Threshold Setting Gi: 25147808
Created: 13-Jul-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative
Feature 1:putative dimerization interface [polypeptide binding site]
Evidence:
  • Comment:based on sequence similarity to mGluR

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 68164778     8 LLALLFsssfar--------agcdpKIVNIGAVL-STKKHEQIFREAVNQANK--RHGTWKLQLNATSVTH--------K 68
gi 67043573     8 LLAVLFlfsfar--------agcdpKIVNIGAVL-STKKHEQIFREAVNQANK--RHFTRKIQLNATSVTH--------R 68
gi 156368325    7 LFLLLAfstys----------vdsaKTFNIGAML-SSTDAIGAFQEAIEAVNVn-NETFPGVKLNASSFIL--------S 66
gi 33243903    10 LLAATYlaccvy--------aqaseQVITIGASL-SSEKMEFEFKQAVNALNR--RHLKSRILFNSTTILM--------D 70
gi 94732623     5 LFAFLIscscar--------ggcepKTVNIGAVL-SQKRYEQVFKDAVTQANN--IYGKDKFKMNAISVTH--------K 65
gi 548377       8 TLALLFscsvar--------aacdpKIVNIGAVL-STRKHEQMFREAVNQANK--RHGSWKIQLNATSVTH--------K 68
gi 24644257    12 LFGLAIvllvapidaaqrhtasdnpSTYNIGGVL-SNSDSEEHFSTTIKHLNFdqQYVPRKVTYYDKTIRM--------D 82
gi 25147808     7 IFIWIFlqlg-----------ytidYKVSVLIVSePNQETFKELKVSVTAAFVe-VFGSTSYHLGNDTISAafvdaksgD 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            # ##  ##                                    #                                
gi 68164778    69 PNAIQMALSVCEDLISSQVYAILVSHPpapndh--ltptpVSYTAGFYRIPVIGLTTRMSIYSDksIHLSFLRTVPPYSH 146
gi 67043573    69 PNAIQMALSVCEDLISSQVYAILVSHPpaptdh--ltptpISYTAGFYRIPVIGLTTRMSIYSDksIHLSFLRTVPPYSH 146
gi 156368325   67 QNPIRSALDVCEQLVAKQVHIVIVSHPngttd----ppisVSYACGFYRIPVIGISARESIFSDktIHESFLRTIPPYSD 142
gi 33243903    71 SNPIRSALDICDKLLAQHVYTVVASHPnstdh----spisVSYTCGYYNIPVVGISARDSAFSDvnVHKMFLRTVPPFAH 146
gi 94732623    66 PNAIQMALSVCEDLISNQVYAILVSHPpqsndh--ltptpVSYTAGFYRIPVVGLTTRMSIYSDksIHLSFLRTVPPYSH 143
gi 548377      69 PNAIQMALSVCEDLISSQVYAILVSHPptpndh--ftptpVSYTAGFYRIPVLGLTTRMSIYSDksIHLSFLRTVPPYSH 146
gi 24644257    83 KNPIKTVFNVCDKLIENRVYAVVVSHEqtsgd---lspaaVSYTSGFYSIPVIGISSRDAAFSDknIHVSFLRTVPPYYH 159
gi 25147808    75 NRLELTQDIVCSQMLNHSLASVIFSPLltsssrfidlvtsSAYTLSFYKLPVVGVMVRDAEFSKknIYPTFVRPTAPLSD 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                            #  #                                # #      
gi 68164778   147 QANVWFEMMRvFNWNHVILIVSDDhegraAQKKLETLLEEREskskkrnyenldqlsydnkrgpKAEKVLQFDPGtknVT 226
gi 67043573   147 QALVWFEMMRlFNWNHVILIVSDDhegraAQKKLETLLEEKEs---------------------KADKVLQFEPGtknLT 205
gi 156368325  143 QADVWLRLLKyFEWNKVILLTSNDqdsraIITRFSTLAEKSDi---------------------KIEKTVMFPSGsenVT 201
gi 33243903   147 QADVWLELLVnLTWHKVIFVYSADeegrsVLSRFQTLAEEHNi---------------------RIEPSVKYAPGeknYT 205
gi 94732623   144 QAQVWFDMMReFQWNHIILIVSDDhegraAQKRLETLLEEREtksknrnyenldqlsfdnkrgpKAEKVLLFSQDt-nLT 222
gi 548377     147 QSSVWFEMMRvYSWNHIILLVSDDhegraAQKRLETLLEEREs---------------------KAEKVLQFDPGtknVT 205
gi 24644257   160 QADVWLEMLShFAYTKVIIIHSSDtdgraILGRFQTTSQTYYddvd---------------vraTVELIVEFEPKlesFT 224
gi 25147808   155 EAFVFLHMLLsLKYRQVVVLSVKRd---iNADQFVEEFEKRRvef-----------------kiIVQRYIEVELNenlND 214
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 68164778   227 SLLLEAKELEARVIILSAseDDAATVYRSAAMLnmTGSGYVWLVGEREisgNALRYAPDGVIGLQLingknESAHISDAV 306
gi 67043573   206 ALLLEAKELEARVIILSAseDDATAVYKSAAMLdmTGAGYVWLVGEREisgSALRYAPDGIIGLQLingknESAHISDAV 285
gi 156368325  202 SYLQQLQKTQSRVILFSAspQDASVVYYNATSLkmTGEGYIWIVTQQAlsgVARENLPQGAIGIELlhgnsEISQLKDAT 281
gi 33243903   206 SVLAPILKHTSRVILLSAstEDAEVIYRDADVLgmTGEGWAWIVSEQA---FDAYNIPVGFLGVHLvngtnEVNHIKDAV 282
gi 94732623   223 ALLQEAKELEARVIILSAseDEAAAIYKVARQLnmTGSGYVWLVGEREmsgKALSEAPDGLLGLQLingknESAHIYDAV 302
gi 548377     206 ALLMEAKELEARVIILSAseDDAATVYRAAAMLnmTGSGYVWLVGEREisgNALRYAPDGILGLQLingknESAHISDAV 285
gi 24644257   225 EHLIDMKTAQSRVYLMYAstEDAQVIFRDAGEYnmTGEGHVWIVTEQA---LFSNNTPDGVLGLQLehahsDKGHIRDSV 301
gi 25147808   215 TLAESFEEVTSNIIVLFAkkDDAVRIFANAGDL--TGKGKVWIVSESA---GEAHNVPNGSLGCRLgq--tAFSVLRDSF 287
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 68164778   307 AVVAQAVHDLFe-KENITDPPRGCVGntniWKTGPLFKRVLMSSKYSegvTGRVEFNEDGDRKFANYSIMNlqn---rkL 382
gi 67043573   286 AVVAQAIHELFe-MENITDPPRGCVGntniWKTGPLFKRVLMSSKYPdgvTGRIEFNEDGDRKFANYSIMNlqn---rkL 361
gi 156368325  282 VISATALQNLAnaGKTLTTPTASCREtq-qWSSGQELFNALVNVSLPrgtTGPIAFNSDGDRKNAVYRLMNrrqsssdaV 360
gi 33243903   283 QVIGHAFWSLLd-TENISNPPTECKDid-sWTDGEKVYNELIKTQLNg-eTGQVSFNSEGDRLNPMYDIMNing--nrrS 357
gi 94732623   303 AVVAQSIQELFe-KENITEPPRGCVGntniWKTGPLFKRVLMSSKYPdglTGRVEFNDDGDRRFAHYSILNyqk---trL 378
gi 548377     286 GVVAQAVHELLe-KENITDPPRGCVGntniWKTGPLFKRVLMSSKYAdgvTGRVEFNEDGDRKFANYSIMNlqn---rkL 361
gi 24644257   302 YVLASAIKEMIs-NETIAEAPKDCGDsavnWESGKRLFQYLKSRNITg-eTGQVAFDDNGDRIYAGYDVINire--qqkK 377
gi 25147808   288 SILKSAMETIFreSKIDIFPPVECDRdsvdAEWNSLQAPALLNEICGt-sTSRVHFNDKCERIGVEYDIINfh----meR 362
                         410       420
                  ....*....|....*....|....*...
Feature 1                                     
gi 68164778   383 VQVGIYngs------nvlTNDRKIIWPG 404
gi 67043573   362 VQVGIFngs------yiiQNDRKIIWPG 383
gi 156368325  361 DVVGLYeng-------hvSINESIIWPG 381
gi 33243903   358 MSVGLYghqek--vlglrMMGRNITWPG 383
gi 94732623   379 VQVGVYngsq-----vvmNAQRKIIWPG 401
gi 548377     362 VQVGIYngt------hviPNDRKIIWPG 383
gi 24644257   378 HVVGKFsydsmrakmrmrINDSEIIWPG 405
gi 25147808   363 KQVGNMvgd------ilrLDEDSIEWAG 384

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