Conserved Protein Domain Family
PBP1_iGluR_delta_like

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cd06381: PBP1_iGluR_delta_like 
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of an orphan family of delta receptors, GluRdelta1 and GluRdelta2
This CD represents the N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of an orphan family of delta receptors, GluRdelta1 and GluRdelta2. While this N-terminal domain belongs to the periplasmic-binding fold type I superfamily, the glutamate-binding domain of the iGluR is structurally homologous to the periplasmic-binding fold type II. The LIVBP-like domain of iGluRs is thought to play a role in the initial assembly of iGluR subunits, but it is not well understood how this domain is arranged and functions in intact iGluR. Although the delta receptors are a member of the ionotropic glutamate receptor family, they cannot be activated by AMPA, kainate, NMDA, glutamate, or any other ligands. Phylogenetic analysis shows that both GluRdelta1 and GluRalpha2 are more homologous to non-NMDA receptors. GluRdelta2 was shown to function as an AMPA-like receptor by mutation analysis. Moreover, targeted disruption of GluRdelta2 gene caused motor coordination impairment, Purkinje cell maturation, and long-term depression of synaptic transmission. It has been suggested that GluRdelta2 is the receptor for cerebellin 1, a glycoprotein of the Clq, and the tumor necrosis factor family which is secreted from cerebellar granule cells. Furthermore, recent studies have shown that the orphan GluRdelta1 plays an essential role in high-frequency hearing and ionic homeostasis in the basal cochlea and that the locus encoding GluRdelta1 may be involved in congenial or acquired high-frequency hearing loss in humans.
Statistics
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PSSM-Id: 107376
View PSSM: cd06381
Aligned: 9 rows
Threshold Bit Score: 450.413
Threshold Setting Gi: 71989779
Created: 17-May-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative
Feature 1:putative dimerization interface [polypeptide binding site]
Evidence:
  • Comment:based on sequence similarity to mGluR

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                              # ##  ##                   
gi 25090493    28 HIGAIFdes--akKDDEVFRTAVGDLNQneeil--qtekITFSVTFVDg-nNPFQAVQEACELMNq--GILALVSSIgct 100
gi 17566612    26 KIGAIFre----rEDAHIEAAVRYSVEWlsqrg--iygdIDLVIEYIDv-lDHYDAIKKACKMLEk-dHIVALLGGShaa 97
gi 118089961   35 XXGAIFdes--akKDEEVFRMAVADLNQndeil--qtekITCSVTFVDg-nNPFQAVQEACDLMNq--GILALVSSIgct 107
gi 134024502   25 HIGAIFeen--avKDDEVFQLAVSDLSLnddil--qsekITYSIKFIEa-nNPFQAVQEACDLMTq--GILALVTSTgca 97
gi 118092396   25 HIGAIFegn--aaKDDEVFKQAVSDLNLnddil--qsekITYSIKLIEa-nNPFHAVQEACDLMTl--GILALVTSTgca 97
gi 38372397    25 HIGAIFeen--aaKDDRVFQLAVSDLSLnddil--qsekITYSIKVIEa-nNPFQAVQEACDLMTq--GILALVTSTgca 97
gi 55583881    28 HIGAIFdes--akKDDEVFRMAVADLNLnneil--etekITVSVEFVDg-nNPFQAVQEACELMNr--GILALVSSIgcm 100
gi 71989779    21 RIGLITsh---hlEHSVRTAVNIIVPRIneqivktrgacFITHTSFIAlknSHEDLNTKICDLANsevSVIIGVVDResg 97
gi 47211653    41 ILGSLPlrwqeeaGGLRNRMFLIDDEIIgqdng--gttsPFLRGSSDQq-pIRRRGAVEACELMNq--GILALVTSTgca 115
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    #                                                                    
gi 25090493   101 sagslqslaDAMHIPHLFIQRstagtprsgcgltrsnrnddytLSVRPPVYLHDVILRVVTeyaWQKFIIFYDSEYDIRG 180
gi 17566612    98 lnaqleritDDLDIPFLTAIDdlrtd------------mgkskIDFWPRPQLFEAVVDMFThwrWNRIVLVYEGDERIRR 165
gi 118089961  108 sagslqslaDAMHIPHLFIQRstggtprsscgltrsnrnddytLSVRPPVYLNDVILRVITeyaWQKFIIFYDNDYDIRG 187
gi 134024502   98 sanalqsltDAMHIPHIFVQRnsggsprtvcqfnpspegeeytLAARPPVRLNDVMLKLVTelrWQKFIVFYDSDYDIRG 177
gi 118092396   98 sanalqsltDAMHIPHLFVQRstggsprtachlnpsleeeeytLAARPPVRLNDVMLKLVTelrWQKFIVFYDSDYDIRG 177
gi 38372397    98 sanalqsltDAMHIPHLFVQRnpggsprtachlnpspdgeaytLASRPPVRLNDVMLRLVTelrWQKFVMFYDSEYDIRG 177
gi 55583881   101 sagslqslaDAMHIPHLFIQRapagtprsscppttraqpddytLFVRPPVYLNDVIFQVVMeytWQKFIIFYDTDYDIRG 180
gi 71989779    98 siieeqcaeLNILFIHYYWTPgyqkk-------------qqtsLNLYPSMEYSQLMERLINlwrWDNFVYIYSNYDAPKQ 164
gi 47211653   116 sasalqsltDAMHIPHLYIQRnsdgsprtacrlnpspggqrytLAARPPVRLNDVMLTLVEelgWQKFIVFYDIEYDIRG 195
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           #  #              # #                                                         
gi 25090493   181 IQEFLDKVSQQGm-dVALQKVENNinkmITTLFDTMRIEelnry-rdtlRRAILVMNPatAKSFITEVVETnlvafDCHW 258
gi 17566612   166 LEQLLESEEYASirfYLIKVHDGDymkaARQVKELEECRllhkkdcsefSRLLVDMNPehTYTFLLASLQMgl-ieLKHW 244
gi 118089961  188 IQEFLDKVSQQGm-dVALQKVENNinkmITGLFATMRIEelnry-rdtlRRAILVMNPltAKSFLTEVVETnlvafDCHW 265
gi 134024502  178 LQGFLDQASRLGl-dVSLQKVDRNisrvFATLFTSMKTEelnry-rdtlRRAILLLSPrgAQSFISEAVETnlaskDSHW 255
gi 118092396  178 LQGFLDQASRLGl-dVSLQKVDRNisrvFANLFTTMKTEelnry-rdtlRRAILLLSPrgAQTFINEAVETnlaskDSHW 255
gi 38372397   178 LQSFLDQASRLGl-dVSLQKVDKNishvFTSLFTTMKTEelnry-rdtlRRAILLLSPqgAHSFINEAVETnlaskDSHW 255
gi 55583881   181 IENFLDQTSQQGm-dVSLQKVESNinmmITGMFRTMRVEelhry-rdtlRRAVLFMSPatAKAFITEVVETnlvafDCQW 258
gi 71989779   165 LIETLSRLEKSP---ALLRAHTLDdsmmATALALRDTCDrnrc--wpkkNRVLIELSPneTLTFFDASLKLgm-isVHNW 238
gi 47211653   196 LQSFLDQTSRQGv-dVALQRVDRNiskvFTNLFTTMRTEelnry-rdtlRRAILLLSPrgAYTFIQQAVETnlaskDSHW 273
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 25090493   259 IIINEEindvdvQELVRRSIGRLTIIRQtfpiPQNISQRCFRGNHRISSTLCdpk----dpFAQNMEISNLYIYDTVLLL 334
gi 17566612   245 FLLTNMelstmdMELFRYNHARFISPYPvd-sTFLTENRDAFNFSHFKEHITekwamktdnSRNLKMMEAVFTFDAVYAF 323
gi 118089961  266 IIINEEisdldvQELVRRSIGRLTIIRQtfpvPQNISQRCFRGNHRISSSLCdpk----dpFSQSMEISNLYIYDTVLLL 341
gi 134024502  256 VYVNEEindaeiVELVHSALGRITVIRQifpsLKDNNIRCVRNNHRIASLPCdpq----egYLQMLQVSNLYLYDSVLML 331
gi 118092396  256 VYVNEEitdneiLELVHSALGRMTVIRQifplSKDNNQRCMRNNHRISSLLCdpq----egYLQMLQVSNLYLYDSVLML 331
gi 38372397   256 VFVNEEisdpeiLDLVHSALGRMTVVRQif-pSAKDNQKCTRNNHRISSLLCdpq----egYLQMLQISNLYLYDSVLML 330
gi 55583881   259 IIINEEisdmdvQELVMKSIGRLTLVRQtfplPQNTSQRCVRNNHRINTSLCdpk----dpKAQMLEITNRYIYDTVLLL 334
gi 71989779   239 FLITALdd--lnDHLSQYTHNGMRVSLLtv-sKEKWNQNDLAIKLPDMYQEYlak---ipsNPRTPFKDFAFIFDSILLA 312
gi 47211653   274 VFVNEEisdteiLELSHSALGRMTVIRQifplWRDSSSRCIRQNHRISSLLCdpq----egYLQNLEVSNLYLYDSVLML 349
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 25090493   335 anafhkkledrkwhsmas--lscirknskpwqggrsmLETIKKGGVSGLTGELEFGEn-GGNPNVHFEILGtnygeelgr 411
gi 17566612   324 anvfnelsshmqmndvpqtlcrkssrnsrkyqhgrslIDNIVHNDLHGLSGDLRRLNghPLKSNFSMRIQLlgysgrldd 403
gi 118089961  342 anafhkkledrkwhsmas--ltcirknskpwqggrsmLETIKKGGVNGLTGELEFAEn-GGNPNVHFEILGtnygedlgr 418
gi 134024502  332 anafhrkledrkwhsmas--lncmrkstkpwnggrsmLDTIKKGRITGLTGIMEFKEa-GANPHVQFEILGtsysetfgk 408
gi 118092396  332 anafhrkledrkwhsmas--lncmrkstkpwnggrsmLETIKKGHITGLTGVMEFREd-GANPYVQFEILGtsysetfgk 408
gi 38372397   331 anafhrkledrkwhsmas--lncirkstkpwnggrsmLDTIKKGHITGLTGVMEFREd-SSNPYVQFEILGttysetfgk 407
gi 55583881   335 antfhrkledrkwhsmas--lscirkgskpwqggksmLETVKKGGVSGLTSLLEFNDn-GSNPNIHFEILGtnygedrgr 411
gi 71989779   313 cqagdrriis------------------cgdneavkkFKLPIVKPFKGLTGKISFNGt-SDRSDSELHIWEmgitgaglh 373
gi 47211653   350 anafyrkledrkwhsmas--lncikkstkpwnggwsmLETIQKGNITGLTGTMDFKDg-GANSHVQFEILGssfsetfgk 426
                         410
                  ....*....|....*..
Feature 1                          
gi 25090493   412 gVRKLGCWNp--VTGLN 426
gi 17566612   404 iGFWEPATNv--HVNMS 418
gi 118089961  419 gIRKLGCWNp--ITGLN 433
gi 134024502  409 dVRRLATWDs--MKGFN 423
gi 118092396  409 dVRRLATWDs--EKGLN 423
gi 38372397   408 dMRKLATWDs--EKGLN 422
gi 55583881   412 gVSRLATWDp--IHGLN 426
gi 71989779   374 tGIWKSTWEg--SKELT 388
gi 47211653   427 dVKRPKWNFpadKTGLC 443

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