Conserved Protein Domain Family
PBP1_iGluR_Kainate

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cd06382: PBP1_iGluR_Kainate 
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the kainate receptors
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the kainate receptors, non-NMDA ionotropic receptors which respond to the neurotransmitter glutamate. While this N-terminal domain belongs to the periplasmic-binding fold type I superfamily, the glutamate-binding domain of the iGluR is structurally homologous to the periplasmic-binding fold type II. The LIVBP-like domain of iGluRs is thought to play a role in the initial assembly of iGluR subunits, but it is not well understood how this domain is arranged and functions in intact iGluR. Kainate receptors have five subunits, GluR5, GluR6, GluR7, KA1, and KA2, which are structurally similar to AMPA and NMDA subunits of ionotropic glutamate receptors. KA1 and KA2 subunits can only form functional receptors with one of the GluR5-7 subunits. Moreover, GluR5-7 can also form functional homomeric receptor channels activated by kainate and glutamate when expressed in heterologous systems. Kainate receptors are involved in excitatory neurotransmission by activating postsynaptic receptors and in inhibitory neurotransmission by modulating release of the inhibitory neurotransmitter GABA through a presynaptic mechanism. Kainate receptors are closely related to AMAP receptors. In contrast of AMPA receptors, kainate receptors play only a minor role in signaling at synapses and their function is not well defined.
Statistics
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PSSM-Id: 107377
View PSSM: cd06382
Aligned: 31 rows
Threshold Bit Score: 252.963
Threshold Setting Gi: 71988861
Created: 17-May-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative
Feature 1:putative dimerization interface [polypeptide binding site]
Evidence:
  • Comment:based on sequence similarity to mGluR

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                    # ##  ##             
gi 17384613    37 RIGGIFeyadgpnaqVMNAEEHAFRFSANIINRnrtl---lpnTTLTYDIQRIhf-hDSFEATKKACDQLAlGVVAIFGP 112
gi 115905843   35 QIGGIFnr-----dgMSSKEELAFRFAIEKLNAkirndpsqnmSMLTYDIQHVrg-nDTFDATKKVCQQLGvGVAAVFGP 108
gi 29029595    26 RIAAILddp----meCSRGERLSITLAKNRINRaper---lgkAKVEVDIFELlr-dSEYETAETMCQILPkGVVAVLGP 97
gi 109109025   26 RIAAILddp----meCSRGERLSITLAKNRINRaper---lgkAKVEVDIFELlr-dSEYETAETMCQILPkGVVAVLGP 97
gi 118101923   26 RIAAILddp----meCSRGERLSITLAKNRINRaper---lgkAKVEVDIFELlr-dSEYETAETMCQILPkGVVGVLGP 97
gi 3287849     25 RMAAILddq----tvCGRGERLALALAREQINGiiev---pakARVEVDIFELqr-dSQYETTDTMCQILPkGVVSVLGP 96
gi 160773959   16 RMAAILdds----svCGRGERLALALARENINSvmen---parARAEVDIFELqk-dSQYETTDTMCQILPkGVVSVIGP 87
gi 24580751    51 NIGAFFy-------dDELELEKEFMTVVNAINGpes----eqtMRFYPLIKRLkpedGSVTMQEHACDLIDnGVAAIFGP 119
gi 45549153    26 KIGAIFf-------dTEMKLADAFSAALEEVNAin-------pALKLDAIKRYvtvdDSIVLQDISCDLIGsGVAAIFGP 91
gi 47213150     2 LLAAILddq----slCGRGERLALALARESVNSlmea---ssqSRVEVDLYELkn-dSQYSTTDTMCQILPkGVVSVIGP 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                         #                                                               
gi 17384613   113 Sqgsctn-avqsiCNALEVPHIQLRWkhhpldn---kdtfyvNLYPDYASLSHAILDLVQyl--kWRSATVVYDDSt--- 183
gi 115905843  109 Tslqdsl-avqsvCDVMDIPHIQTHWepkphl----pgqstiYMHPSNDIVSRAIRDLVKaf--rWKKISIIYDDFn--- 178
gi 29029595    98 SsspasssiisniCGEKEVPHFKVAPeefvkfq--fqrfttlNLHPSNTDISVAVAGILNff--nCTTACLICAKAe--- 170
gi 109109025   98 SsspasssiisniCGEKEVPHFKVAPeefvkfq--fqrfttlNLHPSNTDISVAVAGILNff--nCTTACLICAKAe--- 170
gi 118101923   98 SsspasssiisniCGEKEVPHFRVAPeeflklq--lqrfttlNLHPSNTDISVAVAGILNff--nCTTACLICAKAe--- 170
gi 3287849     97 SsspasastvshiCGEKEIPHIKVGPeetprlq--ylrfasvSLYPSNEDVSLAVSRILKsf--nYPSASLICAKAe--- 169
gi 160773959   88 AsspasgsivshiCGEKEIPHVKIGPeetprlp--ylrfasvTLYPSNEDLSLAIGSILRsf--sYPSASLVCAKAe--- 160
gi 24580751   120 Sskaasd-ivalvCNSTGIPHIEFDIsdegiqaekpnhqmtlNLYPAQAILSKAYADIVQnf--gWRKFTIVYDADda-- 194
gi 45549153    92 Ssktnsd-ivevlCNMTGIPHLQFDWhpqqsnrermnhqltvNVAPMELFLSAAFSDILAsktfdWKSFTIAYERSs--- 167
gi 47213150    74 AsspasgsavshiCGEKEIPHVKIGPeetpklp--ylrfasvTLHPSNEDLSMAIGAMLRsf--gYPPTSIICAKAecec 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                      #  #             # 
gi 17384613   184 -------------------------------------------------------gLIRLQELIMAPSrynirLKIRQLP 208
gi 115905843  179 -------------------------------------------------------gLTRLKDVLMESMhr--dIELTIYY 201
gi 29029595   171 -------------------------------------------------------cLLNLEKLLRQFLiskdtLSVRMLD 195
gi 109109025  171 -------------------------------------------------------cLLNLEKLLRQFLiskdtLSVRMLD 195
gi 118101923  171 -------------------------------------------------------cLLNLEKLLRQFLiskdtLSVRMLD 195
gi 3287849    170 -------------------------------------------------------cLLRLEELVRGFLisketLSVRMLD 194
gi 160773959  161 -------------------------------------------------------cLLRLEELIRRFLisretLSIRMLD 185
gi 24580751   195 ------------------------------------------------------raAARLQDLLQLREvhndvVRVRKFH 220
gi 45549153   168 -------------------------------------------------------hLIRLQHILAWKQlhkagIKMQEFE 192
gi 47213150   150 rfhrdpaerqpsvggrtcspfkqvhrlswthaplstsgrgrwyfcvrqqcdsapsgLLRLEELVQSFLisretLSVRMLD 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #                                                                               
gi 17384613   209 IDsddSRPLLKEMKRGrefRIIFDCsh-------------------------------------------------tmAA 239
gi 115905843  202 TKsmpFGTMMKRIKSSganHIIIDCsr-------------------------------------------------ksLI 232
gi 29029595   196 DTr-dPTPLLKEIRDDktaTIIIHAna-------------------------------------------------smSH 225
gi 109109025  196 DTr-dPTPLLKEIRDDktaTIIIHAna-------------------------------------------------smSH 225
gi 118101923  196 DSr-dPTPLLKEIRDDktaTIIVHAna-------------------------------------------------smSH 225
gi 3287849    195 DSr-dPTPLLKEIRDDkvsTIIIDAna-------------------------------------------------siSH 224
gi 160773959  186 DNl-dPTPLLKEIRDDkiaTIIIDAna-------------------------------------------------siSY 215
gi 24580751   221 KDd-dFRVMWKSIRGEr--RVVLDCep-------------------------------------------------nmLV 248
gi 45549153   193 RGd-dYRILWKRINNArekFVLLDCps-------------------------------------------------diLV 222
gi 47213150   230 DSl-dPTPLLKEIRDDkvaTIIIDAnasvsyrvlrkvstatdrsrspagvglanpgvsrslssptrrtgrrrglltlpPS 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 17384613   240 QILKQAMAMgmmteYYHFIFTTLDlya----ldlEPYRYSGVNLTGFRIlnvdnphVSAIVEKWsmerlqaaprsesgll 315
gi 115905843  233 QLLEKMMQLqmmmdYYHYIITPLDtfs----ldlTRYSGDMVNMTALQLvdmqvpeNMELLREYkeyalrngv----gpe 304
gi 29029595   226 TILLKAAELgmvsaYYTYIFTNLEfsl----qrmDSLVDDRVNILGFSIfnqshafFQEFAQSLnqswqencd----hvp 297
gi 109109025  226 TILLKAAELgmvsaYYTYIFTNLEfsl----qrmDSLVDDRVNILGFSIfnqshafFQEFAQSLnqswqencd----hvp 297
gi 118101923  226 TILQKAAELgmasaYYTYIFTNLEfsl----qrlDSQLDDRVNILGFSIfnqshafFQEFVQSLnqswqencd----hap 297
gi 3287849    225 LILRKASELgmtsaFYKYILTTMDfpi----lhlDGIVEDSSNILGFSMfntshpfYPEFVRSLnmswrence----ast 296
gi 160773959  216 LILKKASELgmtsaFYKYILTTMDfpl----lwlDDIVDEQSNIVGFSMfntthpfYLEFIRSLnlswregcd----inp 287
gi 24580751   249 ELLNSSTEFgltgqYNHIFLTNLEtytdhleelaADNETFAVNITAARLlvnpdppPYSLPYGYvtqrdnivy----ess 324
gi 45549153   223 DVINASIGYnmtgsFNHLFLTNLDthls--gidgFYSRDFTVAVAAVRIrtyvpppVHDEIDVFdnsvdt---------- 290
gi 47213150   309 VFVLQASDLgmmsaFYKYILTTMDfpl----lwlDDVVGDQSNVLGFSMlnsshvsYLDFIRSLnlswregcr----isp 380
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 17384613   316 dgvmmtDAALLYDAVHIVsvcyqrapqmtvnslqchrh---------------kawrfggrfmnfikeaqweGLTGRIVF 380
gi 115905843  305 dagmttEGVITFDGVNLIskalhhanrqtsnlavkalsce-----------rnqpwetgltlhndiestvmkGLTGDVEF 373
gi 29029595   298 ftgpalSSALLFDAVYAVvtavqelnrsqeigvkplscg------------saqiwqhgtslmnylrmveleGLTGHIEF 365
gi 109109025  298 ftgpalSSALLFDAVYAVvtavqelnrsqeigvkplscg------------saqiwqhgtslmnylrmveleGLTGHIEF 365
gi 118101923  298 ftgpalSSALLFDAVYAVvsavqelnrsqeigvkplscg------------saqiwqhgtslmnylrmveleGLTGHIEF 365
gi 3287849    297 ylgpalSAALMFDAVHVVvsavrelnrsqeigvkplact------------saniwphgtslmnylrmveydGLTGRVEF 364
gi 160773959  288 ypgpalSSALLFDAVHVVvsavqelnrsqeigvkplsct------------spqiwqhgtslmnylrmveydGLTGRVEF 355
gi 24580751   325 dpprtlIHDLIHDALQLFaqswrnasffypdrmvvpritcdfaasggrtwamgrylarlmkgvrttfrinrgIETLICEF 404
gi 45549153   291 -rfsslGSQLVYDSIVLFynalleisqrpgfyipnfscgrg--------fwqpgprlveqmkqitpkmvkppFKTQRLQI 361
gi 47213150   381 ypgpavSSTPSGRGGASTltrsc--------------------------------------------ligwkHLTSRSQY 416
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*
Feature 1                                                      
gi 17384613   381 NKtsGLRTDFDLDIIslk-------edGLEKVGVWSp---ADGLN 415
gi 115905843  374 ED--GERSNVVLHVTslh-------eeGMLQVGNWTr---EHGID 406
gi 29029595   366 NSk-GQRSNYALKILqft-------rnGFRQIGQWHv---AEGLS 399
gi 109109025  366 NSk-GQRSNYALKILqft-------rnGFRQIGQWHv---AEGLS 399
gi 118101923  366 NSk-GQRSNYALKILqht-------hsGFRQIGHWHv---SEGLS 399
gi 3287849    365 NSk-GQRTNYTLRILeks-------rqGHREIGVWYs---NRTLA 398
gi 160773959  356 NSk-GQRTNYTLHILekh-------rgGHKEIGIWYs---NNTLL 389
gi 24580751   405 DEd-GQRITFNIEVYdp---------lDGIGIAIWDprgqITQLN 439
gi 45549153   362 NAd-GQREDFNLEVYnp---------iIDRVTHIWNk--eFQLVD 394
gi 47213150   417 PTlmKLASMFTLRWLasrleprtglssVLWQIGTWFs---NNTLV 458

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