Conserved Protein Domain Family
PBP1_iGluR_AMPA_Like

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cd06383: PBP1_iGluR_AMPA_Like 
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of uncharacterized AMPA-like receptors
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of uncharacterized AMPA-like receptors. While this N-terminal domain belongs to the periplasmic-binding fold type I superfamily, the glutamate-binding domain of the iGluR is structurally homologous to the periplasmic-binding fold type II. The LIVBP-like domain of iGluRs is thought to play a role in the initial assembly of iGluR subunits, but it is not well understood how this domain is arranged and functions in intact iGluR. AMPA receptors consist of four types of subunits (GluR1, GluR2, GluR3, and GluR4) which combine to form a tetramer and play an important roles in mediating the rapid excitatory synaptic current.
Statistics
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PSSM-Id: 107378
View PSSM: cd06383
Aligned: 8 rows
Threshold Bit Score: 385.696
Threshold Setting Gi: 31074387
Created: 17-May-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative
Feature 1:putative dimerization interface [polypeptide binding site]
Evidence:
  • Comment:based on sequence similarity to mGluR

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                     # ##  ##           
gi 24581733   18 LWIVFInev-dnEPAAKAVEVVLTYLKKNi-----rYGLSVQLDSiea--------nksDAKVLLEAICNKYATSIek-- 81
gi 21358761   32 KINIFMtydednMLVKQSLDAAISYLEKN-------TGEGAMVDGkhiya----ipkgnDVEVTVNKSCDLMDEAIda-- 98
gi 108874039   2 QISVFVnev-gnDLAQVAVDVALNYIRKNp-----sLGLSVELLTveg--------nrtDSKGLLESLCSKYTEAInt-- 65
gi 66500221   19 RYRVIInde-anKVANQSITTALETIKENypn-hlgNVWSVQVNEs-------------DINNTLDRVCNNWDSAVekgg 83
gi 72112569   25 GAFYGMmtd-kdDEYKRIIDDAVDYVTRQawt--nqNTLRVTHFQpdtnalgepevstnIFQAVQIEVCADARSSS---- 97
gi 31074387   44 GILPSKs-----LPLSEAKSILTSLEDENi------TFSGVRLQEl------------pDDDVIAIKTCLRALRAL---- 96
gi 115934879   1 ALFGTEtg--yqDNYKTIIQDGVRYINRNt------TFLSEVHQLvfvdssi-nsrpsnSVYVALQEGCDHVATSQ---- 67
gi 115916338   1 ALYGEYth--vdDVYKNILTDAQQFINRDfsilptgDEVSVVHFQapdgv----twlrdSVAVAVRAACSFIDNKD---- 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                  #                                                     
gi 24581733   82 kqTPHLILDTTksgiasetvksftqaLGLPTISASYgqqgdlrqwrdldeakqkyllQVMPPADIIPEAIRSIVIhmnit 161
gi 21358761   99 gkPPHIVLDATttgmisetiksftraLTLPTFSASYgqegdirewrkltpseeeylvQLMPPGDIIVQSIRDIVRtqnit 178
gi 108874039  66 nrPPHVIFDTTltgvssetvksisaaLGIPTVSASTgqegdlrqwrslsnvksnyllQVMPPTDIIPEVIRAIVTymnit 145
gi 66500221   84 aeVPDLVIDTTtaglaakisnsftaaLGIPTLSAQYgqvgdlqywrklsadqqdyliQVMPPTDLIPEVIRQLSIqlnit 163
gi 72112569   98 --LRGIVLPHDicmdcnd-isgvigdAINPMVAIDLaggd--------------ysiKLYPDVEDLVDMFAEVINytkwr 160
gi 31074387   97 --KPSAIIGPYsstya-----iatehLRIPYFVTSLtpasqs---------etpyliQLFPSAHALARASVDMLSyyqlk 160
gi 115934879  68 --VSALVLPKDrctasdd-iagvlshATNPVFSIDPgnlgs-----------gstafKMQPSPEDMTSFYIDILSyyswm 133
gi 115916338  71 --AHALIMPDDvcldcgg-lgyvmgdAYLPTIATDQaaes--------------qaiKMYPVKDDMVELISGVVNhyrwt 133
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                         #  #           # #                                             
gi 24581733  162 NAAILYDDSfvmdhkyKSLLQNIQTRHvitAIAKDGKREreEQIEKLRNLDinNFFILGtl-qsIRMVLESVKPAyfe-r 239
gi 21358761  179 NAGIIYDDTfvmehkyKSLLQNLPCRHimtRVEATEKEVr-RQTKRLKDADivNYFAVGsg-dtISRILDAATANdmfgr 256
gi 108874039 146 NAAILYDESfvmdhkyKALLQNFPTRHvitAIGNDRDRA--EQIEKLRNLDinNFFILGsf-asIKKVLESAKREffe-r 221
gi 66500221  164 NAAILYDYNfvmdhkyKSLLLNVPTRHvinETSQQIIEMk-RQLLRLRDLDivNYFILGne-ntISIALEAADALnftdk 241
gi 72112569  161 DFLLIYDGDnaq-givEEMTAQANSRNqtiQILPIGDDMm-EMQKTIEESSikNILLFCqyeeiCLDVVKMAIDEglmid 238
gi 31074387  161 RVAVIYDCEageiileRLAREPWLLVTgyhVTNSSVGGVr-EQLKVMRNMYy-TTFILVltpgrTRYVLDQALSLsmfsk 238
gi 115934879 134 NFTLLYDDGgaf--anMEGVMEYATMNkwnISTVIIDEEfgNNIPMIEERGskNIFIYCsseiiLRNTIDQALLFgtmgp 211
gi 115916338 134 TMIFLYDQDsay--diLSAMMSRTPQHgwvIHPMILADDvqAQMKELKAKAikNIIVYMhveenIKTVVDHAYEEgvltd 211
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 24581733  240 nFAWHAITQNEg-----eISSQRDNATIMFMKPMAYTQYRDRLgllrttyn---lneepqlSSAFYFDLALRSfltiKEM 311
gi 21358761  257 kYAWYALSKDNq-----dIQCGCENASIVYLRPHTSADSRGRIamlqrdyg---ltstpeiDAVAYFEYFMRGilgaAKM 328
gi 108874039 222 nFAWHAITQYQg-----eLSSNIENATIMLLRPVSDSKSKDRLgvirttyn---mkqepqiTTVFYFDLALRTflaiKNI 293
gi 66500221  242 kYGWFLLTPDIni----wPRCECRDISVLFMKPEFDKRNNSDSvefsl--------pkpilLSAFYYDMIRLAvlamKSA 309
gi 72112569  239 gYHWFLGNIDLplt--wdEVRQIRLDGAYITRLQMNKQANVNVryt-------------ttRPENQEEWPFRLknayDAV 303
gi 31074387  239 pNKWFLINVGLqey--dlDKYADSHANVTVLRLMMDYNSSFCGlgenislsraafhdavrlYVHMYTTHALRLsmvgTGE 316
gi 115934879 212 aYTWMIGNMDMgid--rqFLEDLEDSNGFVTRFNMNYTREQQYalp-------------taRNTPTGEWQFRErcafDAV 276
gi 115916338 212 tWHWLFGNPNVaylnknfLETRLRYNSAFITRFKMQVASSVEGtfy-------------trRPDAIRKWPFRQqmtyDSI 278
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 24581733  312 LQSGawpkdmeylncddfqggntpqrnldlrdyftkitepTSYGTFDLvtqst-----------------qpfnGHSFMK 374
gi 21358761  329 AAAGkytdfeylrceefsednp-pvrndfdlrsalqsvsmTNTWASISwgsngm---------------sypdvPLTMDK 392
gi 108874039 294 LQVGawppnmkyltcdeydgtnspnhtidlksafievtepTTYGPFEFpkgk------------------tpfnGHSFMK 355
gi 66500221  310 LDDGewpmeprh--------------------itcdeynnTNTPERKLnffgklkdayknitptyagikwgsrnGEHQAK 369
gi 72112569  304 VLFGeafes--------------------------hrartGSFPTKVAqcptasdt----------ftlssvmqDVKEIN 347
gi 31074387  317 RVSMrrtvr--------------------------klrmdGCTGHLMFsrfgirsesfl----qlmtlqgynldCSSGTW 366
gi 115934879 277 IAVGhglrlyr-----------------------kkrvadGNTGSSVLpgdssmpacpts---slvvnendltyYLKEVT 330
gi 115916338 279 LSVSyalra--------------------------yhdqyGSYPRSGRcgdknspllp------ffnkaqsfegCSGEIS 326
                        410       420       430
                 ....*....|....*....|....*....|....*
Feature 1                                           
gi 24581733  375 FEMDINVLQIrggs-svnSKSIGKWIsglNSELIV 408
gi 21358761  393 FKILAGRTAE--------RKTLGEWSagmPGTLMF 419
gi 108874039 356 FDMDISAVTIrgga-svsTKNLGKWEaslDNALYV 389
gi 66500221  370 FVMSVHLVTIkdgv-vsnTVDSGSWNasiSSPLQL 403
gi 72112569  348 FEGLSGHISFdeny-rrtNYSITVHQg-kGQTVYF 380
gi 31074387  367 RSRPADVSKRvepsksysTVASLSGNvfgDRPLRI 401
gi 115934879 331 FEGITGTVAFddeg-nrvNYTITVRSg-qGETIDQ 363
gi 115916338 327 FDANGNRVNYtidi-fvgKNQYLSTSk-lGVFTQN 359

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