Conserved Protein Domain Family
PBP1_NPR_B

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cd06384: PBP1_NPR_B 
Ligand-binding domain of type B natriuretic peptide receptor
Ligand-binding domain of type B natriuretic peptide receptor (NPR-B). NPR-B is one of three known single membrane-spanning natriuretic peptide receptors that have been identified. Natriuretic peptides are family of structurally related but genetically distinct hormones/paracrine factors that regulate blood volume, blood pressure, ventricular hypertrophy, pulmonary hypertension, fat metabolism, and long bone growth. In mammals there are three natriuretic peptides: ANP, BNP, and CNP. Like NPR-A (or GC-A), NPR-B (or GC-B) is a transmembrane guanylyl cyclase, an enzyme that catalyzes the synthesis of cGMP. NPR-B is the predominant natriuretic peptide receptor in the brain. The rank of order activation of NPR-B by natriuretic peptides is CNP>>ANP>BNP. Homozygous inactivating mutations in human NPR-B cause a form of short-limbed dwarfism known as acromesomelic dysplasia type Maroteaux.
Statistics
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PSSM-Id: 107379
View PSSM: cd06384
Aligned: 5 rows
Threshold Bit Score: 756.251
Threshold Setting Gi: 113916
Created: 7-Feb-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to NPR-C complexed brain natriuretic peptide

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
gi 113916    26 TLAVVLPehnlsyawAWPRVGPAVALAVealg------ralpVDLRFVSSele---gaCSEYLAPLSAVDLKLYhDPDLL 96
gi 1703312   28 TVVVMLPdnhlkysfAFPRVFPAIRMAHddiqkkgkllrgytINLLNHSTesq--gagCSESQAQIMAVDTKLYeKPDAF 105
gi 5821364   60 TLAVVLPesniryawSWPRVAPALRMAVdraqelq-llsgyqVKWVFLTSeln---gaCSEYVAPLNAVDLKLYhNPDVL 135
gi 3834399   27 NIAIVLPhntk-yawAWPRVGPAIQMAIerinndgdllkdyvLTYKYKSSeen---ggCADSLAPLHAVDLKLEsDPDVF 102
gi 2217938   35 TAAVMLPdnyhkypwALPRVFPALLMAQedlhtkhklllghtITILNYSTenpaapgsCAESRAQVVVVDAKLYsRPDVF 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            ##  #   #                 ##                                            #  
gi 113916    97 LGPGCVYpaASVARFASHWRLPLLTAGAVASGFsakndhYRTLVRTGPSAPKLGEFVVTLHGhFNWTARAALLYLDARtd 176
gi 1703312  106 FGPGCVYsvASVGRFVNHWKLPLITAWAPAFGFdsk-eeYRTIVRTGLSTTKLGEFAHYLHShFNWTTRAFMLFHDLKvd 184
gi 5821364  136 FGPGCVYpsASVARFATHWRLPLITAGALAFGFkqdddhYNTTVRTGPTAIKLGEFVSHLHEhFNWSSRAALVYHDVKmd 215
gi 3834399  103 VGPGCIYttAPVARFATHWRLPLVTAAASAFGFsnktgeYNTTIRTGPAYAKLGEFANHIHEtFNWTSRVALLYLDLKtd 182
gi 2217938  115 FGPGCVYplASVGRFVSHWKLPLITAGGPAYGFekl-deYRTIVRIGPSTTKLGAFVNVLHTqFNWTSRAVVIFYDLKqd 193
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           ##  #  ##           #                                                       
gi 113916   177 drpHYFTIEGVFEAl-qGSNLSVQHQVYarep-----ggpEQATHFIRANGRIVYICgPLEMLHEILLQAQREnltngDY 250
gi 1703312  185 drpYYFISEGVFLVl-rRENITVEAVPYddqk----nsdyREMISSLKSNGRIVYICgPLDTFLEFMRIFQNEglppeDY 259
gi 5821364  216 drpHYFIIEGVFLAl-dKEFNNLTVSYQmype----nediGSVIQFIQNNGRVIYICgPLEMLHMIILQAHREkltdgDY 290
gi 3834399  183 erhFFFVTEGIFTSl-qEEFANLSMHPHhigkeeldqsaiIEIIQFIKQHARIVYLCfPFEDFRQIMFYAQKEgltggDY 261
gi 2217938  194 drpHYFLSEGIFMNlkdEMNMTVSARPYtne------qdyKELVSFIKENGRIIYICgPLETFLSIMKLFQSEiqdpeSY 267
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
gi 113916   251 VFFYLDVFGESLragptratgrpwqdnrtreqaqalREAFQTVLVITYreppNPEYQEFQNRLLIRAredfgvelgPSLM 330
gi 1703312  260 AIFYLDMFAKSIldkdykpwe------ssdinwtdpIKLFKSVFVITAkepdNPEYKAFQRELHARAkqefsvqlePSLE 333
gi 5821364  291 VFFYVDVFGESLrpdgtreank----pwqgnhsqelKEAFKTVLVISYhqpeNPEYFEFQKKLIQKSkeefgvelnYSLM 366
gi 3834399  262 VFFYLDVFGESLkvkspgesykp--wqmnhssesvlKEAFKSVMIITYrhpeEPEYLEFQEELRRRAtnvssadldNALV 339
gi 2217938  268 AIFYLDVFAESLthrkpwqn--------akfdwtnpIQVFKSVFVITYhppdNPEYKDFQRKLHARAqrdfgvnlePSLM 339
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
gi 113916   331 NLIAGCFYDGILLYAEVLNETIQEGGTREDGLRIVEkMQGRRYHGVTGLVVMDkNNDRETDFVLWAMgdldsgDFQPAAH 410
gi 1703312  334 DIIAGCFYDGFMLYAQALNETLAEGGSQNDGINITQkMQNRRFWGVTGLVSTDkNNDRDIDFNLWAMtnhktgQYGIVAY 413
gi 5821364  367 NFIAGCFHDGVLLYAQALNETLREGGSQKDGLSIVKkIQDRQMEGITGTVSMDkNNDRNTDFDLWAMtdheegNFEVVGH 446
gi 3834399  340 NFIAGCFYDGVMLYAMALNETLAAGGSKKDGLVITRkMQDRRFPGVTGLVNIDkNGDRDIDFSLWDMvdtetgKYEVVAH 419
gi 2217938  340 DYIAGSFYDGFVLYAMALDETLAEGGAQNNGINITRrTQNRSFWGVTGLVSIDkRNARNIDVDLWAMtnqetgEYGVVSY 419
                       410
                ....*....|.
Feature 1                  
gi 113916   411 YSGAEKQIWWT 421
gi 1703312  414 YNGTNKEIVWS 424
gi 5821364  447 YNGITKQINWT 457
gi 3834399  420 YLGIKKQIYWI 430
gi 2217938  420 YNGSTKEIVWS 430

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