Conserved Protein Domain Family
PBP1_NPR_A

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cd06385: PBP1_NPR_A 
Click on image for an interactive view with Cn3D
Ligand-binding domain of type A natriuretic peptide receptor
Ligand-binding domain of type A natriuretic peptide receptor (NPR-A). NPR-A is one of three known single membrane-spanning natriuretic peptide receptors that regulate blood volume, blood pressure, ventricular hypertrophy, pulmonary hypertension, fat metabolism, and long bone growth. In mammals there are three natriuretic peptides: ANP, BNP, and CNP. NPR-A is highly expressed in kidney, adrenal, terminal ileum, adipose, aortic, and lung tissues. The rank order of NPR-A activation by natriuretic peptides is ANP>BNP>>CNP. Single allele-inactivating mutations in the promoter of human NPR-A are associated with hypertension and heart failure.
Statistics
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PSSM-Id: 107380
View PSSM: cd06385
Aligned: 9 rows
Threshold Bit Score: 760.798
Threshold Setting Gi: 9955248
Created: 7-Feb-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Comment:based on structural similarity to NPR-C complexed with hormone peptide

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
1DP4_A          4 TVAVVLPltNTSYPWSWARVGPAVELALarvkarpdLLPGWTVRMVLGSSENaaGVCSDTAAPLAAVDLKWEhSPAVFLG 83
gi 12313701    46 TLAIILPetNTAYPWAWPRIGPALERAIikinsdpnLLPNHHLTYVFKSSENsnGICSESVAPLVAVDLEFAyKPWAFIG 125
gi 113912      36 TVAVVLPlaNTSYPWSWARVGPAVELALaqvkarpdLLPGWTVRTVLGSSENalGVCSDTAAPLAAVDLKWEhNPAVFLG 115
gi 5821362     30 TMAVLLPktNRVYPWAWPRVGPAIQLAIdrinndpsLLPDLHVQTFLGNSEDkdGVCSDSTAPVVAVDLQFThHPEVFLG 109
gi 15487298    26 TIAVLLPktSTSYPWALPRVGPAIQMAIdrvnadrdLLPDFHLWAVYGDTEDkhKRCSESAAPVTAVDMQFIyHPYVFLG 105
gi 113678661   48 TLAVILPlhNTEYPWAWPRVGPALYWALekvnsdpnLLAGYHLQLVFNSSENkeGLCSDSVAPLVAVDLKFSyNPWAFIG 127
gi 12313664    31 TLAAILPltNTDYPWAWPRVAPALYRAVdsvnsdphLLPGLKLQLVHGSSENreGFCSDSAAPLVAVDLKLShDPWAFIG 110
gi 47210257    38 TLAVILPqsNTEYPWAWPRIGPAIDRAVrtvnanatLLPDHHLTYAFKSSEDkaGICSELAASLMAVDLKLAhNPWAFIG 117
gi 3721601     50 DAGGHPAaaQPHLPLGVAPGGAALVRAMerinedptLLPGYQLRYSYKNSENkqGRCDESIAQLVAVDLKYThNPWAFIG 129
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            ##  #   #                  ##                                            #   
1DP4_A         84 PGCVYSAAPVGRFTAHWRVPLLTAGA-PALGIgvk-deYALTTRTGPSHVKLGDFVTALHRrlgWEHQALVLYADRLgdd 161
gi 12313701   126 PGCSYTASPVGLFTTHWDVPLITAGA-PAIAFld--giYPTITNTGPTHKKLGRFALRICEhfgWREYVTLMFSDNKedd 202
gi 113912     116 PGCVYAAAPVGRFTAHWRVPLLTAGA-PALGFgvk-deYALTTRAGPSYAKLGDFVAALHRrlgWERQALMLYAYRPgde 193
gi 5821362    110 PGCIYTAAPVAVSLPIGRSPLSLWGPpPMASMtkp-tsTSTPPRTGLIPTKLGLFVAHLHQqynWTSRAMIVYRDSSvdd 188
gi 15487298   106 PACIYSAAPVVRFTEHWKVPLITAGA-SAIGFgvkdeeYKYITRTGVVHSKLAQFLMHIHQqynWSSRAMLIYSDDKdd- 183
gi 113678661  128 PGCDYSSSPVARFTTHWEVPMITSGA-RALGFn----lYSSITNIGPTHKKLGEFVLRMHRhfgWDKHAMLMFNDNKndd 202
gi 12313664   111 PGCDYSSSPVARFTTHWDVPMVTAGA-RADGFs----kFAAVTNTGPTHKKLGEFSLKIQEtfgWHHHTMLIFSDNKddn 185
gi 47210257   118 PGCSYTSSPVGLFTTHWDIPMVTAGA-PGHGLlr--qrLPIRHQHGPTHMKLGRSPCTSASt-sWRQHVMLIFSDKKmdd 193
gi 3721601    130 PGCDYTTSTVARFTDYWGLPLVTAGA-PATAFsda-slFTSITNTGPTHRKLGEFALHIHQhfkWLQQAMLLYSDNKvdh 207
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              ##  #  ##           #                                                      
1DP4_A        162 --rpCFFIVEGLYMRvreRLNITVNHQEFvegd-pdhyPKLLRAVRRKGRVIYICSspDAFRNLMLLALNAgltgedYVF 238
gi 12313701   203 --rpCYFAMEGLYEEl-kSINISLQDSVFeenkppinySQILADIQNIGRVMFVCCspDVFRRLMIEFWKAdlpheqYVF 279
gi 113912     194 --ehCFFLVEGLFMRvrdRLNITVDHLEFaedd-lshyTRLLRTMPRKGRVIYICSspDAFRTLMLLALEAglcgedYVF 270
gi 5821362    189 --rpCFFTMEGLYMEl-pKFNLTVVDLQFkdke-ltnyTTLIQDIKQKGRIIYMCCypDMFRQLMIQAWREglcsgdFAF 264
gi 15487298   184 --raCYFTIEGAFVElpkFNNMTVVDMNMkeyg-vinhTSTIQYIKQRGRIIYICCppDDFRQLMLQAWRQglcsgdYVF 260
gi 113678661  203 --rpCYFAVEGPYTQm-rEDNITADDLVFnedeeplryDELLRDISHKARVVYVCCkwETFRKLMVEFWRQgfpqeeYAF 279
gi 12313664   186 dertCYFAIEGLYSLm-gKHNITVFDYFVesn---inhKELVQIIQKNGRVVYLCCswDNMRSLMVQFWKEgvdlenYVF 261
gi 47210257   194 --rpYYFAMEGLYMEl-kHTNITLAERVFeedpalvdyAQILADIRNEGRVIFVCCkpDIFRRLMVQFRREdlphhhYVF 270
gi 3721601    208 --rpFYFATEGLYAEl-kENNLTMEHMSFdehdpsinyETLLQDIEQGGRVVYVCCpwTIFRRLMLYFNNStlpreeYVF 284
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
1DP4_A        239 FHLDVFGqslksaqglvpqkPWERGDGQDRSARQAFQAAKIITYkePDNPEYLEFLKQLKLLAdkkFNFTVEDGLKNIIP 318
gi 12313701   280 LYIDLFAvsls------nkqPWARGDQDDTIAKDAFQSVKILSYrePQNQEYQQFVRDLKADAktsFNYSVQDSLMNIIA 353
gi 113912     271 FHLDIFGqslqggqgpaprrPWERGDGQDVSARQAFQAAKIITYkdPDNPEYLEFLKQLKHLAyeqFNFTMEDGLVNTIP 350
gi 5821362    265 FYVDMWGaslqssifpdpkrPWYRGDADDAKAREAFKAVMIITYkePDNPEYKEFLTNLSRFSgepFHYKEESTLMNVLA 344
gi 15487298   261 FYIDNYGaslqgstfpdyrrPWYRDDADDANAREAFKSVMIITYkePENPEYFEFLQDLKSYAp-kFNHTMESTLMNTVA 339
gi 113678661  280 FFIDLFGrslqs----hparPWARGDADDNAAKEAFKSVKILTYrePQNPEYKDFVSKLKTEAmdmFNFNVEDSLMNLIS 355
gi 12313664   262 FFIDLFAeglgg---ekpgmPWFRGDQDDHAARLAFRSVKVLTYmePQNAEYHQFVETLKKDAekmFNFTIKDSLYNLIA 338
gi 47210257   271 FYIDVFGfglr------agrPWYRGDQDDAAAREAFQSVKILTYrePENLEYQQFLSTLKTDAklmFNYTIQDSLMNIIA 344
gi 3721601    285 FYIDIFGdslgt----epayPWAGQDADDRKAKEAFQYVKILTYhePQNPEYKKFVSDLKEDSkrmFNFTVQDSLKNIIS 360
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
1DP4_A        319 ASFHDGLLLYVQAVTETLAQGgt------vtDGENITQRMWNRSFQGVTGYLKIDrNGDRDTDFSLWDMdp-etGAFRVV 391
gi 12313701   354 GGFYDGLMLYAHALNETALVPga------rpPGKLISGKMWNRTFHGVTGLLHLDvSGDRETDFALWDLvdtnsSSFQIV 427
gi 113912     351 ASFHDGLLLYIQAVTETLAHGgt------vtDGENITQRMWNRSFQGVTGYLKIDsSGDRETDFSLWDMdp-enGAFRVV 423
gi 5821362    345 ASFHDSVLLYAHAVNETRTNGyt------mnNASAITSHMRNKSFYGASGFVKIDdSGDRENDFSLWDMye-ahGTFQIV 417
gi 15487298   340 ADFYDSVMLYAHVVNETREKGes------irNATAIISHMWNRTYYGVSGFLRVDdNGDRENDYSLWDLse-agGDFQVV 412
gi 113678661  356 GSFHDGVMLYSHALNDTMDRSgs------rpPGDVVNKRMWNRTYHGVTGLVQLDeNGDREIDFALWDMtdtktGDYQIV 429
gi 12313664   339 GGFYDGVMLYSRALNETLSKRkpglrpvqrpKGDMVTQRMWNRTFQGVMGTVEMDkFGDREIDFALWDMtdinsGKFEVV 418
gi 47210257   345 GGFYDSVMLYAQVLNETMATAgd------rpAGKLVNARMWNRTFHGVTGKVHLDkNGDRETEFALWDMtdgdsHMFQVH 418
gi 3721601    361 GGFYDGLMLYSHALNETMAGEeg------mpPGTAVTKRMWNRTYYGVTGSVQIDeNGDREVDFALWDMtsnetGVFQIV 434
                         410       420
                  ....*....|....*....|
Feature 1                             
1DP4_A        392 LNYNgTSQELMAVSEHKLYW 411
gi 12313701   428 VVYNsFEEQVTPVPGTSVRW 447
gi 113912     424 LNYNgTSQELVAVSGRKLNW 443
gi 5821362    418 SHYNgTLRKIMALPGREIQW 437
gi 15487298   413 ANYNgTQRSINRVPGREIHW 432
gi 113678661  430 SVYNgSQKQMILEPGMKVHW 449
gi 12313664   419 CVYNsSIKELVLQKGLNFQW 438
gi 47210257   419 THPH-ISEHLRMVPGTIVRW 437
gi 3721601    435 SVYNgSQKQMVSVPGKKIQW 454

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