Conserved Protein Domain Family
PBP1_NPR_C_like

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cd06386: PBP1_NPR_C_like 
Click on image for an interactive view with Cn3D
Ligand-binding domain of type C natriuretic peptide receptor
Ligand-binding domain of type C natriuretic peptide receptor (NPR-C). NPR-C is found in atrial, mesentery, placenta, lung, kidney, venous tissue, aortic smooth muscle, and aortic endothelial cells. The affinity of NPR-C for natriuretic peptides is ANP>CNP>BNP. The extracellular domain of NPR-C is about 30% identical to NPR-A and NPR-B. However, unlike the cyclase-linked receptors, it contains only 37 intracellular amino acids and no guanylyl cyclase activity. Major function of NPR-C is to clear natriuretic peptides from the circulation or extracellular surroundings through constitutive receptor-mediated internalization and degradation.
Statistics
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PSSM-Id: 107381
View PSSM: cd06386
Aligned: 8 rows
Threshold Bit Score: 719.654
Threshold Setting Gi: 47211869
Created: 6-Feb-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:1YKI; human NPR-C complexed with brain natriuretic peptide, contacts calculated at 3.5 A.
    View structure with Cn3D
  • Structure:1YK0; human NPR-C complexed with atrial natriuretic peptide, contacts calculated at 3.5 A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1YK0_A       54 EVLVLLPqddSYLFSLTRVRPAIEYALrsvegngtgrrllppGTRFQVAYEDSDCgNRALFSLVDRVAAargaKPDLILG 133
1JDN_A       11 EVLVLLPqddSYLFSLTRVRPAIEYALrsvegngtgrrllppGTRFQVAYEDSDCgNRALFSLVDRVAAargaKPDLILG 90
1YK1_A       53 EVLVLLPqddSYLFSLTRVRPAIEYALrsvegngtgrrllppGTRFQVAYEDSDCgNRALFSLVDRVAAargaKPDLILG 132
gi 1215784   28 DVLIILPknnSYHFSISMVAPAIDYAQkkmksv----nglysGLNFNFHYENSNCgDEALFRLVDRSCQk---KPDLILG 100
gi 1532269   28 EVLVLLPknnSYIFSMPRVRPAIEYAKirlsa------dlypGLNFTVHYDNSDCgNEALFSLVSRSCTk---KPDLILG 98
gi 10443730  28 NMLVLLPkdnSYMFSMDRVKPAIDHALssiqen----qtllpGVHFNVIYNDSDCgNQALFSLIDIAMQl--qKPDVILG 101
gi 42760899  27 DVLVFLPqnnSFLFSSARVAPALRYAQrrlqag----egnfsGFHFNLHFQSSDSpNEALFALVDRSCAr---KPDLILG 99
gi 47211869  27 EVLAFLPqnnSYLFSSARVAPAVLYAQrrlea-----darfsGFRFNVHFEDSDCvNGAMFALVERACAr---KPHLILG 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          ##  #   #                 ##                                           #     
1YK0_A      134 PVCEYaAAPVARLASHWDLPMLSAGALAAGFqhkdsEYSHLTRVAPAYAKMGEMMLALFRhhhWSRAALVYSDDKleRNC 213
1JDN_A       91 PVCEYaAAPVARLASHWDLPMLSAGALAAGFqhkdsEYSHLTRVAPAYAKMGEMMLALFRhhhWSRAALVYSDDKleRNC 170
1YK1_A      133 PVCEYaAAPVARLASHWDLPMLSAGALAAGFqhkdsEYSHLTRVAPAYAKMGEMMLALFRhhhWSRAALVYSDDKleRNC 212
gi 1215784  101 PVCEYaAAPVARMASHWNIPVISAGALASGFsy-kkEYSHLTRVVPSYLKMAETFSAMFHrfnWKNAFLIYEDDMdqRNC 179
gi 1532269   99 PVCEYaAAQVVRMASHWNIPVISAGALATGFshkekEYSHLTRIAPSYLKMGETFSALFEhfgWNKVLLIFEDDSeeRNC 178
gi 10443730 102 PVCEYaAASVARLASHWNVPMLSSGALAVGFmqkssEYSHLTRVSPVYSKMGEMFLAMFRyhkWTKAFLLYTDDTqqRNC 181
gi 42760899 100 PVREYeAAGVARLASHWDIPMISAGALAAGFgnknsEFSQLTRIAPHYVKMAETFSALFErfgWRSALLLYEEDKqeRNC 179
gi 47211869  99 PVCEYeAAAVVRLASHWNVPVVSAGALAAGFskkktEYAQLTRIAPSYVKMGEIFAAMFErfdWRSALLVYEDDRqeRNC 178
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1       ##  #  ##          #                                                            
1YK0_A      214 YFTLEGVHEVfqEEGLHTSIYSFDetkd----ldlEDIVRNIQASe-rVVIMCassDTIRSIMLVAHRHgmtsgdYAFFN 288
1JDN_A      171 YFTLEGVHEVfqEEGLHTSIYSFDetkd----ldlEDIVRNIQASe-rVVIMCassDTIRSIMLVAHRHgmtsgdYAFFN 245
1YK1_A      213 YFTLEGVHEVfqEEGLHTSIYSFDetkd----ldlEDIVRNIQASe-rVVIMCassDTIRSIMLVAHRHgmtsgdYAFFN 287
gi 1215784  180 YFTLEGVHNIlkTENVHIDALNIHskdn---kvdsDEIIKLIYDSe--VIIMCagaDIIRDIMLAAHRRrltngsYIFFN 254
gi 1532269  179 YFTIEGVHSSlhVEGYKVDSVVIHkdhr----vetDEIIKDIYKTe-aVVVMCaggDTVRDIMLAAHRRrltsggYIFFN 253
gi 10443730 182 FFTLEGVHLAfkEEGYAMSIHNFDetkh----vdaEEIVHAIQNKe-rVVIMCassDTVRNIMLAAHRQgmtngdYVFFN 256
gi 42760899 180 YFTLEGVYHL--MSDYPVSQYPVLegdp----lhvDEIIHSMNDSe--VVIMCmgaERIRGIMLAAHRHqltrgrKIFFS 251
gi 47211869 179 FFTLEGIYHM--LHDVDMKTYPLDdgvaldtdklkSALILALRVTiiqLVIMCmpaEKIRELMLAAHARqltggnHMFFN 256
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1YK0_A      289 IELFNSSSYGDGSWKRGDKHDfeAKQAYSSLQTVTLLRTvKPEFEKFSMEVKSSVekqg---lnmEDYVNMFVEGFHDAI 365
1JDN_A      246 IELFNSSSYGDGSWKRGDKHDfeAKQAYSSLQTVTLLRTvKPEFEKFSMEVKSSVekqg---lnmEDYVNMFVEGFHDAI 322
1YK1_A      288 IELFNSSSYGDGSWKRGDKHDfeAKQAYSSLQTVTLLRTvKPEFEKFSMEVKSSVekqg---lnmEDYVNMFVEGFHDAI 364
gi 1215784  255 IELFNSSSYGNGSWKRGDKFDmdAKQAYATLNTVTLLRTvKPEFEDFSMEVKKSLqkagi-rhcdSDNINVFVEGFHDAL 333
gi 1532269  254 IELFNSSSYGDGSWRRGDKYDaeAKLAYSALNVVTLMRTaKAEFETFTTEVKKSIqrag--igpdSANVNMFMEGFHDAL 331
gi 10443730 257 IELFNSSTYGNGSWKRGDKYDleAKQAYSSLQTVTLLRTvKPEFEKFSMEVKSSVqklg---lndDDYVNMFVEGFHDAI 333
gi 42760899 252 IELFNASSYGDGSWRRDDEHDseAKQAYASLNTITLLRTvKPEFENFSLEMKSSAekegiydckdCGSVNMFVEGFHDAM 331
gi 47211869 257 VDLFNASSYGNGSWKKGDKHDnnAKQAFAFLNTVTLLRTvKPEFEVFSEEMKASVkkaefqdcndCADVNMFVEGFHDAV 336
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1YK0_A      366 LLYVLALHEVLRAGyskkDGGKIIQQTWNRTFEGIAGQVSIDaNGDRYGDFSVIAMTDVEAGTQEVIGDYFgkegRFEMR 445
1JDN_A      323 LLYVLALHEVLRAGyskkDGGKIIQQTWNRTFEGIAGQVSIDaNGDRYGDFSVIAMTDVEAGTQEVIGDYFgkegRFEMR 402
1YK1_A      365 LLYVLALHEVLRAGyskkDGGKIIQQTWNRTFEGIAGQVSIDaNGDRYGDFSVIAMTDVEAGTQEVIGDYFgkegRFEMR 444
gi 1215784  334 LLYAMAVVEVTQNGsnktDGARITQRMWNRTFEGIAGPVSIDaNGDRYGDFSVMAMVDHETGTYEDVINYFgingSFQML 413
gi 1532269  332 LLYALALHEVVKNGfskkDGVQITQSMRNRTFEGIAGQVSIDeNGDRNGDFSVMAMTDTQSGTYEAVFNYFgvnqSFQIM 411
gi 10443730 334 ILYALALHELLKNGfsqkDGEKLVQQMWNRTYEGIAGQVSIDaNGDRYGDFSVIAMTDKETGTQEVIGDYYgiqgHFEIR 413
gi 42760899 332 LLYAIALHEAMKHGyskkNGTEVTSRMWNRTIEGIAGQISIDtNGDRNGDFSVMAMTDVEAGTFEVVANYFgvnrTLELL 411
gi 47211869 337 LLYAIALYEATKHGyskrNGTEITSRMWNRTFEGIAGPVSIDeNGDRNGDFSLIAMTNTSSGTYEVAPSRHwqlgGEAVA 416

                .
Feature 1        
1YK0_A      446 P 446
1JDN_A      403 P 403
1YK1_A      445 P 445
gi 1215784  414 P 414
gi 1532269  412 P 412
gi 10443730 414 P 414
gi 42760899 412 P 412
gi 47211869 417 N 417

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