Conserved Protein Domain Family
PBP1_iGluR_AMPA_GluR3

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cd06387: PBP1_iGluR_AMPA_GluR3 
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor. The AMPA receptor is a member of the glutamate-receptor ion channels (iGluRs) which are the major mediators of excitatory synaptic transmission in the central nervous system. AMPA receptors are composed of four types of subunits (GluR1, GluR2, GluR3, and GluR4) which combine to form a tetramer and play an important role in mediating the rapid excitatory synaptic current. Furthermore, this N-terminal domain of the iGluRs has homology with LIVBP, a bacterial periplasmic binding protein, as well as with the structurally related glutamate-binding domain of the G-protein-coupled metabotropic receptors (mGluRs).
Statistics
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PSSM-Id: 107382
View PSSM: cd06387
Aligned: 3 rows
Threshold Bit Score: 781.14
Threshold Setting Gi: 164419726
Created: 11-Feb-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative
Feature 1:putative dimerization interface [polypeptide binding site]
Evidence:
  • Comment:based on sequence similarity to mGluR

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                         # ##  ##                       
gi 77416864   35 SIGGLFMRNTVQEHSAFRFAVQLYNTNQNtTEKPFHLNYHVDHldSSNSFSVTNAFCSQFSRGVYAIFGFYDqmSMNTLT 114
gi 38198631   28 NIGGLFMRSTVQEHSAFRFAVQLYNTNQNiTEKPFHLNYNVDNleSSNSFSVTHAFCSQFSRGVYAIFGFYDrrSMNTLT 107
gi 164419726  29 SIGGLFMRNTVQEHSAFRFAVQLYNTNQNtTEKPFHLNYHVDHldSSNSFSVTNAFCSQFSRGVYAIFGFYDqmSMNTLT 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             #                                                       #  #             # 
gi 77416864  115 SFCGALHTSFVTPSFPTDaDVQFVIQMRPALKGAILSLLGhYKWEKFVYLYDTErgFSILQAIMEAAVQNNWQVTARSVG 194
gi 38198631  108 SFCGALHTSFITPSFPTDtDVQFVLQMRPSLRGALLSLLAhYKWEKFVYLYDTDrgFSILQAIMESAVMNNWQVTARSVG 187
gi 164419726 109 SFCGALHTSFITPSFPTDaDVQFVIQMRPALKGAILSLLTyYKWEKFVYLYDTErgFSILQAIMEAAVQNNWQVTARSVG 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #                                                                               
gi 77416864  195 NIkdvqeFRRIIEEMDRRqekRYLIDCEVerINTILEQVVILgkhSRGYHYMLANLGFtdillERVMHGGANITGFQIVN 274
gi 38198631  188 NIvdpleYRRIIEEMDRRqekRFLIDCEVerINSILEQVVIAgknSRGYHYILANLGFtnmslDKVFPGGANITGFQIIN 267
gi 164419726 189 SIkdvqeFRRIIEEMDRRqekRYLIDCEVdrINTILEQVVILgkhSRGYHYMLANLGFtdivlERVMHGGANVTGFQIVN 268
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 77416864  275 nenpmVQQFIQRWvrLDEREFpeaknaPLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGsagDCLANPAVPWSQGidI 354
gi 38198631  268 pdspiVQQFLQRRerLDEREFpesrssPLKYTSALTHDAILVIAEAFRYLRRQRVDISRRGsagDCLANPAVPWSQGidI 347
gi 164419726 269 nenpmVQQFLQRWvrLDEREFpeaknsPLKYTSALTHDAVLVIAEAFRYLRRQRVDVSRRGsagDCLANPAVPWSQGidI 348
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
Feature 1                                                            
gi 77416864  355 ERALKMVQVQGMTGNIQFDTYGRRTNYTIDVYEMkvsGSRKAGYWNEYERFV 406
gi 38198631  348 ERALKMVQVQGMTGNIQFDSFGRRSNYTVDVYEMkpgGARKIGYWNEFEKFV 399
gi 164419726 349 ERALKMVQVQGMTGNIQFDTYGRRTNYTIDVYEMkasGSRKAGYWNEYERFV 400

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