Conserved Protein Domain Family
PBP1_iGluR_AMPA_GluR2

?
cd06389: PBP1_iGluR_AMPA_GluR2 
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor. The AMPA receptor is a member of the glutamate-receptor ion channels (iGluRs) which are the major mediators of excitatory synaptic transmission in the central nervous system. AMPA receptors are composed of four types of subunits (GluR1, GluR2, GluR3, and GluR4) which combine to form a tetramer and play an important role in mediating the rapid excitatory synaptic current. Furthermore, this N-terminal domain of the iGluRs has homology with LIVBP, a bacterial periplasmic binding protein, as well as with the structurally related glutamate-binding domain of the G-protein-coupled metabotropic receptors (mGluRs).
Statistics
?
PSSM-Id: 107384
View PSSM: cd06389
Aligned: 3 rows
Threshold Bit Score: 762.249
Threshold Setting Gi: 23831146
Created: 11-Feb-2008
Updated: 17-Jan-2013
Structure
?
Aligned Rows:
 
putative
Feature 1:putative dimerization interface [polypeptide binding site]
Evidence:
  • Comment:based on sequence similarity to mGluR

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                   # ##  ##                            #
gi 33327158   27 QIGGLFPRGADQEYSAFRIGMVQFGTAEFRLTPHIDNLEVANSFAVTNCFCSQFSRGVYAIFGFYDKkSVNTITSFCGTL 106
gi 161377423  28 QIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRGVFAIFGFYDKkSVNTITSFCGTL 107
gi 23831146   28 QIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKkSVNTITSFCGTL 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                               #  #             # #     
gi 33327158  107 HVSFITPSFPlDGNQQFIIQMRPDIKGPLLSLIEYYkWDKFAYLYDSDRGLTTLQVVLDTAAEKKwQVTAINVGNMkder 186
gi 161377423 108 HVSFITPSFPtDGTHPFVIQMRPDLKGALLSLIEYYqWTKFAYLYDSDRGLSTLQAVLDSAAEKKwQVTAINVGNInndr 187
gi 23831146  108 HVSFITPSFPtDGTHPFVIQMRPDLKGALLSLIEYYqWDKFAYLYDSDRGLSTLQAVLDSAAEKKwQVTAINVGNInndk 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 33327158  187 kdeaYRSLFQDLENKkerRVILDCEQdkVKDIMEQVITIgrHVKGYHYIIANLGFvdgdlSKIQYGGANVSGFQIVDFDD 266
gi 161377423 188 kdetYRSLFQDLEVKkerRVILDCERdkVNDIVDQVITIgkHVKGYHYIIANLGFtdgdlSKIQFGGANVSGFQIVDYDD 267
gi 23831146  188 kdemYRSLFQDLELKkerRVILDCERdkVNDIVDQVITIgkHVKGYHYIIANLGFtdgdlLKIQFGGANVSGFQIVDYDD 267
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 33327158  267 plVSKFDQRWEALEEKEYPGAdsk-iryTSALTYDAVQVMTEAFRYLHKQRIDISRRANNGDCLANPAVPWAQGveIERA 345
gi 161377423 268 plVSKFIQRWSTLEEKEYPGAhtstikyTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGHGveIERA 347
gi 23831146  268 slVSKFIERWSTLEEKEYPGAhtttikyTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGveIERA 347
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
Feature 1                                                          
gi 33327158  346 LKQVRVDGLTGNIQFDQYGKRVNYTVNVMELksnGAVKIGYWNEVDKMVV 395
gi 161377423 348 LKQVQVEGLTGNIKFDQNGKRINFTINVMELkstGPRKIGYWSEVDKMVV 397
gi 23831146  348 LKQVQVEGLSGNIKFDQNGKRINYTINIMELktnGPRKIGYWSEVDKMVV 397

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap