Conserved Protein Domain Family
PBP1_iGluR_delta_2

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cd06391: PBP1_iGluR_delta_2 
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the delta2 receptor of an orphan glutamate receptor family
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the delta2 receptor of an orphan glutamate receptor family. While this N-terminal domain belongs to the periplasmic-binding fold type I superfamily, the glutamate-binding domain of the iGluR is structurally homologous to the periplasmic-binding fold type II. The LIVBP-like domain of iGluRs is thought to play a role in the initial assembly of iGluR subunits, but it is not well understood how this domain is arranged and functions in intact iGluR. Although the delta receptors are a member of the ionotropic glutamate receptor family, they cannot be activated by AMPA, kainate, NMDA, glutamate, or any other ligands. Phylogenetic analysis shows that both GluRdelta1 and GluRalpha2 are closer related to non-NMDA receptors. GluRdelta2 was shown to function as an AMPA-like receptor by mutation analysis. Moreover, targeted disruption of GluRdelta2 gene caused motor coordination impairment, Purkinje cell maturation, and long-term depression of synaptic transmission. It has been suggested that GluRdelta2 is the receptor for cerebellin 1, a glycoprotein of the Clq and tumor necrosis factor family that is secreted from cerebellar granule cells.
Statistics
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PSSM-Id: 107386
View PSSM: cd06391
Aligned: 3 rows
Threshold Bit Score: 857.016
Threshold Setting Gi: 55583881
Created: 19-Dec-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative
Feature 1:putative dimerization interface [polypeptide binding site]
Evidence:
  • Comment:based on sequence similarity to mGluR

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                         # ##  ##                        
gi 25090493    28 HIGAIFDESAKKDDEVFRTAVGDLNQNEEILQTEKITFSVTFVDGNNPFQAVQEACELMNqGILALVSSIGCTSAGSLQS 107
gi 55583881    28 HIGAIFDESAKKDDEVFRMAVADLNLNNEILETEKITVSVEFVDGNNPFQAVQEACELMNrGILALVSSIGCMSAGSLQS 107
gi 118089961   35 XXGAIFDESAKKDEEVFRMAVADLNQNDEILQTEKITCSVTFVDGNNPFQAVQEACDLMNqGILALVSSIGCTSAGSLQS 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             #                                                                      #  # 
gi 25090493   108 LADAMHIPHLFIQRstaGTPRSGCgltrsnrnDDYTLSVRPPVYLHDVILRVVTeyaWQKFIIFYDSEYDIRGIQEFLDK 187
gi 55583881   108 LADAMHIPHLFIQRapaGTPRSSCppttraqpDDYTLFVRPPVYLNDVIFQVVMeytWQKFIIFYDTDYDIRGIENFLDQ 187
gi 118089961  115 LADAMHIPHLFIQRstgGTPRSSCgltrsnrnDDYTLSVRPPVYLNDVILRVITeyaWQKFIIFYDNDYDIRGIQEFLDK 194
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                     # #                                                                 
gi 25090493   188 VSQQGmdVALQKVENNinkmITTLFDTMRIEelnryRDTLRRAILVMNPatAKSFITEVVETnLVAFDCHWIIINEEIND 267
gi 55583881   188 TSQQGmdVSLQKVESNinmmITGMFRTMRVEelhryRDTLRRAVLFMSPatAKAFITEVVETnLVAFDCQWIIINEEISD 267
gi 118089961  195 VSQQGmdVALQKVENNinkmITGLFATMRIEelnryRDTLRRAILVMNPltAKSFLTEVVETnLVAFDCHWIIINEEISD 274
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 25090493   268 vDVQELVRRSIGRLTIIRQTFPIPQNISQRCFRGNHRISSTLCDPKDPFAQNMEISNLYIYDTVLLLANaFHKKLEDRKW 347
gi 55583881   268 mDVQELVMKSIGRLTLVRQTFPLPQNTSQRCVRNNHRINTSLCDPKDPKAQMLEITNRYIYDTVLLLANtFHRKLEDRKW 347
gi 118089961  275 lDVQELVRRSIGRLTIIRQTFPVPQNISQRCFRGNHRISSSLCDPKDPFSQSMEISNLYIYDTVLLLANaFHKKLEDRKW 354
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 25090493   348 HSMASLSCIRKNSKPWQGGRSMLETIKKGGVSGLTGELEFGENGGNPNVHFEILGTNYGeelGRGVRKLGCWNPVTGLNG 427
gi 55583881   348 HSMASLSCIRKGSKPWQGGKSMLETVKKGGVSGLTSLLEFNDNGSNPNIHFEILGTNYGedrGRGVSRLATWDPIHGLNG 427
gi 118089961  355 HSMASLTCIRKNSKPWQGGRSMLETIKKGGVNGLTGELEFAENGGNPNVHFEILGTNYGedlGRGIRKLGCWNPITGLNG 434

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