Conserved Protein Domain Family
PBP1_iGluR_delta_1

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cd06392: PBP1_iGluR_delta_1 
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the delta1 receptor of an orphan glutamate receptor family
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the delta1 receptor of an orphan glutamate receptor family. While this N-terminal domain belongs to the periplasmic-binding fold type I superfamily, the glutamate-binding domain of the iGluR is structurally homologous to the periplasmic-binding fold type II. The LIVBP-like domain of iGluRs is thought to play a role in the initial assembly of iGluR subunits, but it is not well understood how this domain is arranged and functions in intact iGluR. Although the delta receptors are a member of the ionotropic glutamate receptor family, they cannot be activated by AMPA, kainate, NMDA, glutamate, or any other ligands. Phylogenetic analysis shows that both GluRdelta1 and GluRalpha2 may be closer related to non-NMDA receptors. In contrast to GluRdelta2, GluRdelta1 is expressed in many areas in the developing CNS, including the hippocampus and the caudate putamen. Furthermore, recent studies have shown that the orphan GluRdelta1 plays an essential role in high-frequency hearing and ionic homeostasis in the basal cochlea and that the locus encoding GluRdelta1 may be involved in congenial or acquired high-frequency hearing loss in humans.
Statistics
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PSSM-Id: 107387
View PSSM: cd06392
Aligned: 4 rows
Threshold Bit Score: 821.557
Threshold Setting Gi: 47211653
Created: 19-Dec-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative
Feature 1:putative dimerization interface [polypeptide binding site]
Evidence:
  • Comment:based on sequence similarity to mGluR

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                           # ##  ##                      
gi 118092396   25 HIGAIFe--gNAAKDDEVFKQAVSDLNLNDdiLQSEKITYSIKLIEAnNPFHAVQEACDLMTlGILALVTSTGCASANAL 102
gi 134024502   25 HIGAIFe--eNAVKDDEVFQLAVSDLSLNDdiLQSEKITYSIKFIEAnNPFQAVQEACDLMTqGILALVTSTGCASANAL 102
gi 38372397    25 HIGAIFe--eNAAKDDRVFQLAVSDLSLNDdiLQSEKITYSIKVIEAnNPFQAVQEACDLMTqGILALVTSTGCASANAL 102
gi 47211653    41 ILGSLPlrwqEEAGGLRNRMFLIDDEIIGQdnGGTTSPFLRGSSDQQpIRRRGAVEACELMNqGILALVTSTGCASASAL 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               #                                                                      #  
gi 118092396  103 QSLTDAMHIPHLFVQRstggsprtachlnpsleeeeytLAARPPVRLNDVMLKLVTelrWQKFIVFYDSDYDIRGLQGFL 182
gi 134024502  103 QSLTDAMHIPHIFVQRnsggsprtvcqfnpspegeeytLAARPPVRLNDVMLKLVTelrWQKFIVFYDSDYDIRGLQGFL 182
gi 38372397   103 QSLTDAMHIPHLFVQRnpggsprtachlnpspdgeaytLASRPPVRLNDVMLRLVTelrWQKFVMFYDSEYDIRGLQSFL 182
gi 47211653   121 QSLTDAMHIPHLYIQRnsdgsprtacrlnpspggqrytLAARPPVRLNDVMLTLVEelgWQKFIVFYDIEYDIRGLQSFL 200
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #             # #                                                               
gi 118092396  183 DQASRLGldVSLQKVDRNISrvFANLFTTMKTEelnrYRDTLRRAILLLSPrgAQTFINEAVETnlaskDSHWVYVNEEI 262
gi 134024502  183 DQASRLGldVSLQKVDRNISrvFATLFTSMKTEelnrYRDTLRRAILLLSPrgAQSFISEAVETnlaskDSHWVYVNEEI 262
gi 38372397   183 DQASRLGldVSLQKVDKNIShvFTSLFTTMKTEelnrYRDTLRRAILLLSPqgAHSFINEAVETnlaskDSHWVFVNEEI 262
gi 47211653   201 DQTSRQGvdVALQRVDRNISkvFTNLFTTMRTEelnrYRDTLRRAILLLSPrgAYTFIQQAVETnlaskDSHWVFVNEEI 280
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 118092396  263 tdnEILELVHSALGRMTVIRQIFPlSKDNNQRCMRNNHRISSLLCDPQEGYLQMLQVSNLYLYDSVLMLANAFHRKLEDR 342
gi 134024502  263 ndaEIVELVHSALGRITVIRQIFPsLKDNNIRCVRNNHRIASLPCDPQEGYLQMLQVSNLYLYDSVLMLANAFHRKLEDR 342
gi 38372397   263 sdpEILDLVHSALGRMTVVRQIFP-SAKDNQKCTRNNHRISSLLCDPQEGYLQMLQISNLYLYDSVLMLANAFHRKLEDR 341
gi 47211653   281 sdtEILELSHSALGRMTVIRQIFPlWRDSSSRCIRQNHRISSLLCDPQEGYLQNLEVSNLYLYDSVLMLANAFYRKLEDR 360
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 118092396  343 KWHSMASLNCMRKSTKPWNGGRSMLETIKKGHITGLTGVMEFREDGANPYVQFEILGTSYSETFGKDVRRLATWDs--EK 420
gi 134024502  343 KWHSMASLNCMRKSTKPWNGGRSMLDTIKKGRITGLTGIMEFKEAGANPHVQFEILGTSYSETFGKDVRRLATWDs--MK 420
gi 38372397   342 KWHSMASLNCIRKSTKPWNGGRSMLDTIKKGHITGLTGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDs--EK 419
gi 47211653   361 KWHSMASLNCIKKSTKPWNGGWSMLETIQKGNITGLTGTMDFKDGGANSHVQFEILGSSFSETFGKDVKRPKWNFpadKT 440

                  ....
Feature 1             
gi 118092396  421 GLNG 424
gi 134024502  421 GFNG 424
gi 38372397   420 GLNG 423
gi 47211653   441 GLCV 444

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