Conserved Protein Domain Family
PBP1_iGluR_Kainate_GluR5_7

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cd06393: PBP1_iGluR_Kainate_GluR5_7 
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR5-7 subunits of Kainate receptor
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR5-7 subunits of Kainate receptor. While this N-terminal domain belongs to the periplasmic-binding fold type I superfamily, the glutamate-binding domain of the iGluR is structurally homologous to the periplasmic-binding fold type II. The LIVBP-like domain of iGluRs is thought to play a role in the initial assembly of iGluR subunits, but it is not well understood how this domain is arranged and functions in intact iGluR. There are five types of kainate receptors, GluR5, GluR6, GluR7, KA1, and KA2, which are structurally similar to AMPA and NMDA subunits of ionotropic glutamate receptors. KA1 and KA2 subunits can only form functional receptors with one of the GluR5-7 subunits. Moreover, GluR5-7 can also form functional homomeric receptor channels activated by kainate and glutamate when expressed in heterologous systems. Kainate receptors are involved in excitatory neurotransmission by activating postsynaptic receptors and in inhibitory neurotransmission by modulating release of the inhibitory neurotransmitter GABA through a presynaptic mechanism. Kainate receptors are closely related to AMAP receptors. In contrast of AMPA receptors, kainate receptors play only a minor role in signaling at synapses and their function is not well defined.
Statistics
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PSSM-Id: 107388
View PSSM: cd06393
Aligned: 3 rows
Threshold Bit Score: 811.176
Threshold Setting Gi: 9837162
Created: 11-Feb-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative
Feature 1:putative dimerization interface [polypeptide binding site]
Evidence:
  • Comment:based on sequence similarity to mGluR

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                  # ##  ##              
gi 9837162    35 QVLRIGGIFEtle---nePISVEELAFKFAVTNINRNRTLmPNTTLTYDIQRInlfDSFEASRRACDQLALGVAAVFGPS 111
gi 118101697  34 HVIRIGGIFEytdgpntqVMSAEEQAFRFSANIINRNRTLlPNTTLTYDIQRIhfhDSFEATKKACDQLALGVVAIFGPS 113
gi 17384613   34 HVIRIGGIFEyadgpnaqVMNAEEHAFRFSANIINRNRTLlPNTTLTYDIQRIhfhDSFEATKKACDQLALGVVAIFGPS 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                      #                                                             #  #
gi 9837162   112 hsssvsAVQSICNALEVPHIQTRWkhpsvdnkdsfyiNLYPDYASISRAVLDIVQfykWKAVTVVYEDAtgLIRLQELIK 191
gi 118101697 114 qgsctnAVQSICNALEVPHIQLRWkhhpldnkdtfyvNLYPDYASLSHAILDLVQylkWRSATVVYDDStgLIRLQELIM 193
gi 17384613  114 qgsctnAVQSICNALEVPHIQLRWkhhpldnkdtfyvNLYPDYASLSHAILDLVQylkWRSATVVYDDStgLIRLQELIM 193
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                     # #                                                                
gi 9837162   192 APSRYSikIKIRQLPTGskdARPLLKEMKKGkefCVIFDCSfqtAADVLKQLLSMgmmteYYHFFFTTLDLFAldlEPYR 271
gi 118101697 194 APSRYNirLKIRQLPLDtddARPLLKEMKRGrefRIIFDCShlmAAQILRQAMAMgmmteYYHFIFTTLDLYAldlEPYR 273
gi 17384613  194 APSRYNirLKIRQLPIDsddSRPLLKEMKRGrefRIIFDCShtmAAQILKQAMAMgmmteYYHFIFTTLDLYAldlEPYR 273
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 9837162   272 YSGVNMTGFRLLNIdnpqVASVVEKWSMERLQappkpetGLLDGMMTTEAALMYDAVYMVAaasqrasqiTVSSLQCHRH 351
gi 118101697 274 YSGVNLTGFRILNVenphVSSIIEKWAMERLQsapkaelGLLDGVMMTDAALLYDAVHVVSvcyqrapqmTVNSLQCHRH 353
gi 17384613  274 YSGVNLTGFRILNVdnphVSAIVEKWSMERLQaaprsesGLLDGVMMTDAALLYDAVHIVSvcyqrapqmTVNSLQCHRH 353
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
Feature 1                                                                                      
gi 9837162   352 KPWRFGSRFISMFKEAQWNGLTGQIIINKTDGLRKDFDMDIISLKEDgmekpfmesgrlnkVWKKVGVWNSNTGLNLT 429
gi 118101697 354 KAWRFGGRFMNFIKEAQWEGLTGRIVFNKSSGLRTDFDLDIISLKED--------------GLEKVGTWNPSNGLNIT 417
gi 17384613  354 KAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKED--------------GLEKVGVWSPADGLNIT 417

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