Conserved Protein Domain Family
PB1_NBR1

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cd06396: PB1_NBR1 
Click on image for an interactive view with Cn3D
The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves heterodimerization of two PB1 domain, is required for the formation of macromolecular signaling complexes ensuring specificity and fidelity during cellular signaling. The interaction between two PB1 domain depends on the type of PB1. There are three types of PB1 domains: type I which contains an OPCA motif, acidic aminoacid cluster, type II which contains a basic cluster, and type I/II which contains both an OPCA motif and a basic cluster. The NBR1 protein contains a type I PB1 domain.
Statistics
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PSSM-Id: 99718
View PSSM: cd06396
Aligned: 5 rows
Threshold Bit Score: 124.188
Threshold Setting Gi: 156388111
Created: 27-Feb-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
PB1 interaction
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:PB1 interaction site [polypeptide binding site]
Evidence:
  • Comment: NBR1 contains a type I PB1 domain with an acidic amino acid OPCA motif

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                       # # #        #                    
2BKF_A          7 VTLNVTFknEIQSFLVsdpentTWADIEAMVKVSFDLn-tIQIKYLDEENEEVSINSQGEYEEALKMAvkqgnQLQMQVH 85
gi 118103047    5 VNLRVSYrgETQSFLVsdtahtTWADVEAMVKVSFDLd-dIQIKYIDEDNDEVSVNSKEEYEEALKIAvkqgnQLQMNVY 83
gi 146327515   34 INLKVTFrgNAKSFLLsgsetkSWESMEAMVKRSFGLc-nLQLTYFDEENEEVSVNSQLEYEEALKSAarqgnRLQMNVY 112
gi 156388111    5 VKVKATYnnISRRFEIps--cvEWSSFHALLQDYFGFeesCSTKYVDDESELVLLNSQAELDEAIRLIqrnskLLRIFVE 82
gi 147905864    5 VNLCVSCngESQNFLVsdsentTWADVETMVLVSYDLn-dIQIKYMDEDNEEVSVNSQGENEEALKSAvkqggLLRMNVY 83

                  ..
Feature 1           
2BKF_A         86 EG 87
gi 118103047   84 EE 85
gi 146327515  113 ET 114
gi 156388111   83 DH 84
gi 147905864   84 EK 85

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