Conserved Protein Domain Family
PB1_UP1

?
cd06397: PB1_UP1 
Uncharacterized protein 1. The PB1 domain is a modular domain mediating specific protein-protein interaction which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 interaction, which involves heterodimerization of two PB1 domain, is required for the formation of macromolecular signaling complexes ensuring specificity and fidelity during cellular signaling. The interaction between two PB1 domain depends on the type of PB1. There are three types of PB1 domains: type I which contains an OPCA motif, acidic aminoacid cluster, type II which contains a basic cluster, and type I/II which contains both an OPCA motif and a basic cluster. Interactions of PB1 domains with other protein domains have been described as noncanonical PB1-interactions.
Statistics
?
PSSM-Id: 99719
View PSSM: cd06397
Aligned: 4 rows
Threshold Bit Score: 109.556
Threshold Setting Gi: 66802964
Created: 27-Feb-2008
Updated: 17-Jan-2013
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
EDR15809    4 TQFKLSKldGHTRRIVFpd-lpTWEALASRLEHLYAIpldkIGVSYIDNdnDEITLSSNNELQDFYRLshr----sneVI 78  Laccaria bicolor S...
EAU92815    3 VNFKFKFg-QETRRITFpd-ipSWASLSEKLQSIYNLpqvaVAVSYVDSdnDEITLNSEEELQDYYRQasrs---qgeVY 77  Coprinopsis cinere...
EDR09728    4 TQFKISQl-NGQTRLVEfpdipTWEALASKLEPLYAIpsekVGVTYIDNdnDEITLSSNDELQNFYRRshl----sdkVI 78  Laccaria bicolor S...
XP_635325   3 ITYKSNFe-GDVRRFSSdh-plTYTRLQDKLVNLYNLyeisFGITYLDDg-DNITIADAKDLEEAHNLlgneilrltiTR 79  Dictyostelium disc...
EDR15809   79 KFAVLDL 85  Laccaria bicolor S238N-H82
EAU92815   78 RLNVVDL 84  Coprinopsis cinerea okayama7#130
EDR09728   79 KFKIFDL 85  Laccaria bicolor S238N-H82
XP_635325  80 KLNENKN 86  Dictyostelium discoideum AX4
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap