Conserved Protein Domain Family
PB1_Joka2

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cd06398: PB1_Joka2 
The PB1 domain is present in the Nicotiana plumbaginifolia Joka2 protein which interacts with sulfur stress inducible UP9 protein. The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development and cell polarity. A canonical PB1-PB1 interaction, which involves heterodimerization of two PB1 domain, is required for the formation of macromolecular signaling complexes ensuring specificity and fidelity during cellular signaling. The interaction between two PB1 domain depends on the type of PB1. There are three types of PB1 domains: type I which contains an OPCA motif, acidic aminoacid cluster, type II which contains a basic cluster, and type I/II which contains both an OPCA motif and a basic cluster. Interactions of PB1 domains with other protein domains have been described as noncanonical PB1-interactions. The PB1 domain module is conserved in amoebas, fungi, animals, and plants.
Statistics
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PSSM-Id: 99720
View PSSM: cd06398
Aligned: 9 rows
Threshold Bit Score: 116.741
Threshold Setting Gi: 115447045
Created: 27-Feb-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93280150    2 IVIKVKYEETLRRFNArvine-kldlNMDGLSDKIFQLFNIardaeLILTYVDEDGDVVTLVDDEDLQDVMRQd------ 74
gi 125548712  18 LVVKVKFGGTLKRFTAfvngp-hfdlNLAALRSKIASAFKFnpdteFVLTYTDEDGDVVILDDDSDLCDAAISq------ 90
gi 115447045  21 VVLKVKYGETLKRFGGyvqgp-qfslNLSALRSKIASAFKFgsdvdFILTYTDEDGDIVMLDDDDDLHDAAIHq------ 93
gi 116785594   3 LVVKVKYQGILRRLTLqlreeyvpeiNMDALKCKIRELFKLnpnadMSITYTDEDGDVVTMADDVDFLDAVRQg------ 76
gi 164650374  15 LIVKCTFDKWHKRITFssa----rncSYDLLRHKVEQCFSLys-tsYAIAYKDDDGEITNITTETDLTEAIQYfqagdda 89
gi 116507364  11 LVVKCTFDKANKKITFnsa----rncSFNVLKEKVEKCFSLr---sSIISWRDDDGETSQIVSDPDLAEAVQYfcsgdds 83
gi 147794209 192 NGKVVKYGNTLRRFNAcvdengqldlDINGLRAKVITLFNLvpdadLTLTHIDEDGDVVTLVDDEDLHDVMKSlrk---- 267
gi 58268928   17 LVVRCSYEGSSRRVNFpsa----atcRLESLRNRVEECFSLsa-apYSLIYTDDDGEEFSIRNENDLTEAISYfisgddd 91
gi 75313180    8 LVVKVSYGGVLRRFRVpvkangqldlEMAGLKEKIAALFNLsadaeLSLTYSDEDGDVVALVDDNDLFDVTNQr------ 81
                         90       100       110
                 ....*....|....*....|....*....|....
gi 93280150   75 ---------------------LNPLRISVRLNAA 87
gi 125548712  91 --------------------rLNPLRINVELKSS 104
gi 115447045  94 --------------------kLNPLRINVQLNNS 107
gi 116785594  77 ---------------------LNPLRLDVSLATE 89
gi 164650374  90 plssa----asilsgrsfgprKVTLRVSITVDYD 119
gi 116507364  84 aplssa---asilsgrsfgsrKITLRVTITVDYD 114
gi 147794209 268 ------------------kqkPFGHRLDQSVVNC 283
gi 58268928   92 aatsnysgsvsgvlpyslstsKITLRLDVVVEYD 125
gi 75313180   82 ---------------------LKFLKINVNAGVS 94
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