Conserved Protein Domain Family
PB1_TFG

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cd06401: PB1_TFG 
The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development and cell polarity. A canonical PB1-PB1 interaction, which involves heterodimerization of two PB1 domains, is required for the formation of macromolecular signaling complexes ensuring specificity and fidelity during cellular signaling. The interaction between two PB1 domain depends on the type of PB1. There are three types of PB1 domains: type I which contains an OPCA motif, acidic aminoacid cluster, type II which contains a basic cluster, and type I/II which contains both an OPCA motif and a basic cluster. The PB1 domains of TFG represent a type I/II PB1 domain. The physiological function of TFG remains unknown.
Statistics
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PSSM-Id: 99722
View PSSM: cd06401
Aligned: 9 rows
Threshold Bit Score: 105.673
Threshold Setting Gi: 66826367
Created: 27-Feb-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41351004   11 LIIKAQLGDDIRRIPIHNEDiTYDELLLMMQRVFRGqlqssdeVTIKYKDEDDDLITIFD--SSDLSFAIQCsr---iLK 85
gi 82113970   11 LIIKAQLGEDIRRIPIHNEDiTYDELVLMMQRVFRGklltndeVTIKYKDEDGDLITIFD--SSDLSFAIQCsr---iLK 85
gi 50729668   11 LIIKAQLGEDIRRIPIHNEDiTYDELVLMMQRVFRGkllsndeVTIKYKDEDGDLITIFD--SSDLSFAIQCsr---iLK 85
gi 41688743   11 LIVKAQLGEDIRRIPIHNEDiTYDELVLMMQRVFRGkllsndeVTIKYKDEDGDLITIFD--SSDLSFAIQCsr---iLK 85
gi 115665540  17 LIIKAQLGDDIRRIPIHNEDiTYDELVLMMQRVYRGklnpsdeVVIKYKDEDGDLITIFD--STDLSFAIQCsr---iLK 91
gi 91078978   14 LIIKVQLGDDIRRIPIHNEAiTYDELLLMMQRVFKGklfasddITIKYKDEDGDLITIFD--SSDLSFAIQCsr---iLK 88
gi 156386794   7 LIIKAQLGDDIRRIPIHNEDlTYDELLLMMQRVFRGklnssddVLIKYKDEDGDLVTIFD--SSDLSFAKSMsr---iLR 81
gi 66826367    4 LILKIQHNDDTRRVSMERDP-TFLELRKMTVTFFKIn-----sFLIKYFDEDKDLITITSdnDLKEAFSIATts---pRT 74
gi 42601344    2 VILKTEFKGDRRNIPLANEQlTFDDLLLMLCRIYSAdig--ddDLVKYLDSENDWITMND--SNDLSFAIQLaeddgrKF 77

                 ....*.
gi 41351004   86 LTLFVN 91
gi 82113970   86 LTLFVN 91
gi 50729668   86 LTLFVN 91
gi 41688743   86 LTLFVN 91
gi 115665540  92 ITLFVN 97
gi 91078978   89 LQILPN 94
gi 156386794  82 LTLFGK 87
gi 66826367   75 VRLFVS 80
gi 42601344   78 LKIKVG 83
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