Conserved Protein Domain Family
PB1_p62

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cd06402: PB1_p62 
The PB1 domain is an essential part of p62 scaffold protein (alias sequestosome 1,SQSTM) involved in cell signaling, receptor internalization, and protein turnover. The PB1 domain is a modular domain mediating specific protein-protein interaction which play roles in many critical cell processes. A canonical PB1-PB1 interaction, which involves heterodimerization of two PB1 domains, is required for the formation of macromolecular signaling complexes ensuring specificity and fidelity during cellular signaling. The interaction between two PB1 domain depends on the type of PB1. There are three types of PB1 domains: type I which contains an OPCA motif, acidic aminoacid cluster, type II which contains a basic cluster, and type I/II which contains both an OPCA motif and a basic cluster. Interactions of PB1 domains with other protein domains have been described as noncanonical PB1-interactions. The PB1 domain module is conserved in amoebas, fungi, animals, and plants.
Statistics
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PSSM-Id: 99723
View PSSM: cd06402
Aligned: 9 rows
Threshold Bit Score: 130.531
Threshold Setting Gi: 156377106
Created: 27-Feb-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59861145    3 LSVKAYLnfe-egnPEIRRFSIeqd-----------vsaSYEYLMEKIRRVYPSllr-knFQLFWRDEEEELVAFSSDEE 69
gi 156400995   3 LSVKAYLlqd-dgnQEIRRFAVdeg-----------vstNYDYLVQKVQSVFPNvrg-rgIRLYWKDSDEELVTFSSDEE 69
gi 115922476   3 MTVKAYLkrgenanAEIRRFVIdva-----------vssNYEYLSKKVAQVFPSlgdpdyFSLSWKDSEGDNITFSSDDE 71
gi 47207916    3 LTVKAYLlgkdeavKEVRRFAVdhd-----------vssSFEYLCRKTAEIFSNlkn-saFTMFYKDEDEDLVAFSSDDE 70
gi 148230116   3 VTVKAYLlgkdeshKEIRRFQLelpvagkg--kaassgsSCEILANKVTDVFQGlkg-gaFQMFYKDEEGDLVAFSTDEE 79
gi 74735628    4 LTVKAYLlgkedaaREIRRFSFccspepeaeaeaaagpgPCERLLSRVAALFPAlrp-ggFQAHYRDEDGDLVAFSSDEE 82
gi 156377116   3 VHIKAYLnag-teeEEIRRFSAdeg-----------aatSFLWLQEKIKSLFPPiqg-reVEISWHDEDGEVVRLSSDEE 69
gi 156377106   4 ILVKAYLhpd-tqkQEIRRIHVdel-----------ttkKYCDFVPKVTAAFPElkeaenVKLFWKDQENDLICLSTDSE 71
gi 156537980   9 VFLRKNNsrn-dnhAEIRRFAIdad-----------vvtNFTYLREKLQTVFPDlrg-krFTITWKDFENDEIVICSCEE 75
                         90       100
                 ....*....|....*....|.
gi 59861145   70 LVIALGSss-gdNFRVYIKVQ 89
gi 156400995  70 LVEALGSln-gnVFRLFIKPV 89
gi 115922476  72 LVEALGQin-ddTFRIYVKEK 91
gi 47207916   71 LMMGLGCmk-daTFRIFIKEK 90
gi 148230116  80 LHMGLSLln-edVFRIYIKEK 99
gi 74735628   83 LTMAMSYvk-ddIFRIYIKEK 102
gi 156377116  70 LTMALCSka-ddVLYVYVKMA 89
gi 156377106  72 LSEAMSHqssddTVRVFLKTA 92
gi 156537980  76 LVIALAElqkypLCKLFVTLH 96
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