1WMH


Conserved Protein Domain Family
PB1_Par6
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cd06403: PB1_Par6 
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The PB1 domain is an essential part of Par6 protein which in complex with Par3 and aPKC proteins is crucial for establishment of apical-basal polarity of animal cells. The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes. A canonical PB1-PB1 interaction, which involves heterodimerization of two PB1 domains, is required for the formation of macromolecular signaling complexes ensuring specificity and fidelity during cellular signaling. The interaction between two PB1 domain depends on the type of PB1. There are three types of PB1 domains: type I which contains an OPCA motif, acidic aminoacid cluster, type II which contains a basic cluster, and type I/II which contains both an OPCA motif and a basic cluster. Interactions of PB1 domains with other protein domains have been described as noncanonical PB1-interactions. The PB1 domain module is conserved in amoebas, fungi, animals, and plants. The Par6 protein contains a type II PB1 domain.
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Statistics
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PSSM-Id: 99724
Aligned: 10 rows
Threshold Bit Score: 130.521
Created: 27-Feb-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PB1 interaction
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:PB1 interaction surface [polypeptide binding site]
Evidence:
  • Structure:1WMH; Human PKCiota and Par6alpha form an asymmetric heterodimer
    - View structure with Cn3D
  • Comment:Par6 contains a type II PB1 domain and aPKC contains a type I/II PB1 domain
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         # #      ### #                #   #                                          # 
1WMH_B         7 VEVKSKFDAEFRRFALpra--svsGFQEFSRLLRAVHQIpg-ldVLLGYTDA-HGDLLPLTNDDSLHRALASg-pPPLRL 81  human
Q9NAN2        15 LQVKSKFDSEWRRFSIpmhsasgvSYDGFRSLVEKLHHLes-vqFTLCYNST-GGDLLPITNDDNLRKSFESa-rPLLRL 91  Caenorhabditis ...
O97111        20 IEVKSKFDAEFRRWSFkrne-aeqSFDKFASLIEQLHKLtn-iqFLILYIDPrDNDLLPINNDDNFGRALKTa-rPLLRV 96  fruit fly
Q9BYG4        19 VEVKSKFGAEFRRFSLdrh--kpgKFEDFYKLVVHTHHIsn-sdVTIGYADV-HGDLLPINNDDNFCKAVSSa-nPLLRV 93  human
NP_001038106  17 MEVKSKFGAEFRRFSLers--kpgKFEEFYGLLQHVHKIpn-vdVLVGYTDV-HGDLLPINNDDNYHKAVSTa-nPLLRI 91  chicken
NP_001081992  18 VEVKSKFGAEFRRFALekt--kpgKFEEFYGLLQHVHKIpn-veVLVGYADI-HGDLLPINNDDNYLKAMTTa-nPLLRI 92  African clawed ...
NP_997728     19 VEVKSKYGAEFRRFSVdri--kpgKFEEFYKLIMTIHRIan-meVMIGYADI-HGDLLPINNDENFSKAVSTa-hPLLRI 93  zebrafish
XP_001120877  14 VAVKSKFDADIIRFSVnrn--dtiNYEDFRKLLAERHDIgpdlsFLIWYTDPtDGDLLPINNDNNLARALLAa-kPLLRI 90  honey bee
BAF99001      28 KEIKSKLDAEFRRFTInpn--kvgTYEDFYAFLERMHHLgd-vpFLVGYTDP-QGDLLPINNDDNYLKALTSs-kPPLKI 102 Hemicentrotus p...
AAX89405      20 LQVKSKYQAEFRRFPLdln---rdNFEDFFHRLQSLHHLan-fdFVITYTDPvHSDLLPINNDENFTKAKQScvnSLMRV 95  warty sea squirt

Feature 1             
1WMH_B        82 LVQKR 86  human
Q9NAN2        92 LIQRR 96  Caenorhabditis elegans
O97111        97 IVQRK 101 fruit fly
Q9BYG4        94 FIQKR 98  human
NP_001038106  92 FIQRK 96  chicken
NP_001081992  93 FLQRK 97  African clawed frog
NP_997728     94 FIQRQ 98  zebrafish
XP_001120877  91 FIQRI 95  honey bee
BAF99001     103 VLQKR 107 Hemicentrotus pulcherrimus
AAX89405      96 YVHRK 100 warty sea squirt

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