Conserved Protein Domain Family
PB1_P67

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cd06406: PB1_P67 
Click on image for an interactive view with Cn3D
A PB1 domain is present in p67 proteins which forms a signaling complex with p40, a crucial step for activation of NADPH oxidase during phagocytosis. PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes . A canonical PB1-PB1 interaction, which involves heterodimerization of two PB1 domains, is required for the formation of macromolecular signaling complexes ensuring specificity and fidelity during cellular signaling. The interaction between two PB1 domain depends on the type of PB1. There are three types of PB1 domains: type I which contains an OPCA motif, acidic aminoacid cluster, type II which contains a basic cluster, and type I/II which contains both an OPCA motif and a basic cluster. Interactions of PB1 domains with other protein domains have been described as noncanonical PB1-interactions. The PB1 domain module is conserved in amoebas, fungi, animals, and plants. The p67 proteins contain a type II PB1 domain.
Statistics
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PSSM-Id: 99727
View PSSM: cd06406
Aligned: 7 rows
Threshold Bit Score: 123.338
Threshold Setting Gi: 147899077
Created: 3-Mar-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
PB1 interaction
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:PB1 interaction surface [polypeptide binding site]
Evidence:
  • Structure:1OEY; Human PB1 domain of p67 and p40 form an asymmetric heterodimer
    View structure with Cn3D
  • Comment:p40 contains a type I PB1 domain and p67 contains a type II PB1 domain

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             #         #                #                                   #           
1OEY_A         4 XAYTLKVHYKYTVVXKTQPGLPYSQVRDXVSKKLELRLEHTKLSYRPRdsneLVPLSEDSXKDAWGQVKNYCLTLWCENT 83
gi 147899077 363 ASYLVKVYYKYTVAIQISRKLAYADLLTIISSKLQLLPSTIKLSYKKDe--tDVLLNEENTEKAWSLATDNCLRLKCTEV 440
gi 51472303  355 SLCVVKVHFTYTITMCMVPGLPYTTTLEKISNKLGLPAMAITLSYAHLdsgkIVIDEDTRMEDVWSCVHNGRLTLWCDLK 434
gi 151427610 348 KPYVLKVHYKYTVAMQVKPDLSYKELLGLVCDKLELQPEHTMLRYKSAasgeLVPLSAQNLEEAWSHSKDQCLTVWCDCT 427
gi 160333871 350 SGCVVKVHFQFTIAIAIAHGQPYGVILQMISSKLKLPASTLTLRYAKEgsaeRVIIEDSEMEAVWNSAKDGRLTLWCSVT 429
gi 47225189  355 DSYVVKVRFTFTFAVIVPRGSSYATLAQKVGEKLSVPADAVILSLSSEaaeeDVINGSTDMEAVWGRASGRCITLWCRLA 434
gi 122936673 351 DECIVKVHFTFTFTICVARGASYATLAEKIASKLKLPVTSITLSYSLMrt-kKTINQDTKMEDVWSQVNNGHLTLWCTLQ 429

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