Conserved Protein Domain Family
PB1_NLP

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cd06407: PB1_NLP 
A PB1 domain is present in NIN like proteins (NLP), a key enzyme in a process of establishment of symbiosis betweeen legumes and nitrogen fixing bacteria (Rhizobium). The PB1 domain is a modular domain mediating specific protein-protein interaction which play a role in many critical cell processes like osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 interaction, which involves heterodimerization of two PB1 domains, is required for the formation of macromolecular signaling complexes ensuring specificity and fidelity during cellular signaling. The interaction between two PB1 domain depends on the type of PB1. There are three types of PB1 domains: type I which contains an OPCA motif, acidic aminoacid cluster, type II which contains a basic cluster, and type I/II which contains both an OPCA motif and a basic cluster. Interactions of PB1 domains with other protein domains have been described as noncanonical PB1-interactions. The PB1 domain module is conserved in amoebas, fungi, animals, and plants.
Statistics
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PSSM-Id: 99728
View PSSM: cd06407
Aligned: 10 rows
Threshold Bit Score: 112.802
Threshold Setting Gi: 125580730
Created: 27-Feb-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33468530  817 HRVKVTYGDEKTRFRMpk-swSYEHLLQEIARRFNVsdm--skFDVKYLDDDLEWVLLTCDADLEECIDVClss--esST 891
gi 115450519 845 LKIKAIYGEERCIFRLqp-swGFQRLKEEIVKRFGIsqd--thVDLKYLDDESEWVLLTCDADLLECIDVYkss--snQT 919
gi 75266410  674 MKVKAMFGDSMLRMSLlp-hsRLTDLRREIAKRFGMddvlrsnFSLKYLDDDQEWVLLTCDADLEECIQVYkss-slkET 751
gi 125606541 798 MRVKVTFGSEKVRFRLkp-ecDFQELKQEISKRLSIadm--nsLIVKYLDDDSEWVLMTCDADLHECFHVYkla--diQT 872
gi 75272058  781 FRVKATFADEKIRFSLqp-iwGFSDLQLEIARRFNLndv--tnILLKYLDDDGEWVVLACDGDLEECKDIHrss--qsRT 855
gi 75205167  748 VSIKATYREDIIRFKIspesvSITELKQQVAKRLKLet---aaFELKYLDDDREWVSVSCDADLSECLDTSaa---kaNT 821
gi 168036338 698 VTVKATFGADTVRFKLlv-ksSYLELRTEISGRLKVdd---qgFDLKYLDDEEEWMLITCDADVKECIEVArtl--grHT 771
gi 75173883  745 LRIKVSYGEEKIRLRMrn-srRLRDLLWEIGKRFSIedm--srYDLKYLDEDNEWVLLTCDEDVEECVDVCrtt--psHT 819
gi 75097615  848 LIVKASYREDTVRFKFep-svGCPQLYKEVGKRFKLqd---gsFQLKYLDDEEEWVMLVTDSDLQECLEILhgm--gkHS 921
gi 125580730 551 VTIKASHRGDIIRFRVpc-saGVAAVKAVVAKRLSLda---gaFDVKYLDDDHEWVLLSCDADFQECLDVVpalpsmsVT 626

                 ....*..
gi 33468530  892 IKLCIQA 898
gi 115450519 920 VRILVNP 926
gi 75266410  752 IRILVHH 758
gi 125606541 873 IKISVHL 879
gi 75272058  856 IRLSLFQ 862
gi 75205167  822 LRLSVHD 828
gi 168036338 772 VKLMVRE 778
gi 75173883  820 IKLLLQA 826
gi 75097615  922 VKFLVRD 928
gi 125580730 627 ARSGSGA 633
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