Conserved Protein Domain Family
PB1_NoxR

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cd06408: PB1_NoxR 
The PB1 domain is present in the Epichloe festucae NoxR protein (NADPH oxidase regulator), a key regulator of NADPH oxidase isoform, NoxA. NoxA is essential for growth control of the fungal endophyte in plant tissue in the process of symbiotic interaction between a fungi and its plant host. The Epichloe festucae p67(phox)-like regulator, NoxR, dispensable in culture but essential in plants for the symbiotic interaction. Plants infected with a noxR deletion mutant show severe stunting and premature senescence, whereas hyphae in the meristematic tissues show increased branching leading to increased fungal colonization of pseudostem and leaf blade tissue. The PB1 domain is a modular domain mediating specific protein-protein interactions which a play role in many critical cell processes such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 interaction, which involves heterodimerization of two PB1 domains, is required for the formation of macromolecular signaling complexes ensuring specificity and fidelity during cellular signaling. The interaction between two PB1 domain depends on the type of PB1. There are three types of PB1 domains: type I which contains an OPCA motif, acidic aminoacid cluster, type II which contains a basic cluster, and type I/II which contains both an OPCA motif and a basic cluster. Interactions of PB1 domains with other protein domains have been described as noncanonical PB1-interactions. The PB1 domain module is conserved in amoebas, fungi, animals, and plants.
Statistics
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PSSM-Id: 99729
View PSSM: cd06408
Aligned: 7 rows
Threshold Bit Score: 137.196
Threshold Setting Gi: 164647296
Created: 28-Feb-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
BAF36501     429 RKIRVKVHA-GDVRYIMIGAAIEYPDFVDRIKDKFGMkr-rFKIKIPDEdmpdGDMITVGDQDDLEMAIQSstslaKRQR 506 Epichloe festucae
XP_001240705 453 KKIRVKVHAdQDTRFIMIGPAIEFGALEGKIREKFGFks-kLKIKMRDD----GDMVTLGDQDDLDMLLSTarqaaRKQG 527 Coccidioides im...
BAE65134     245 RRFRVKVHAvEDTRYIIIGPTIGFSEFEMKIRDKFGFrg-lLKIRMQDE----GDMITMVDQEDLDLLFSSaretaIREG 319 Aspergillus oryzae
XP_001536353 460 RKIRAKVHAsSDVRFIMIGGSVGYNEFEAKIRDKFGFkq-rMRMQMQDD----GDMVTMGDQDDLDMLLTAakqeaRKDG 534 Ajellomyces cap...
XP_384299    419 TKIRVKVHA-DEVKLIMITPDTRFETLSDKVRDKFNIkr-rFKIKVKDDdmpnGDMITVGDQDDLEMVIDSvkdeaRKQR 496 Gibberella zeae...
EAT84610     438 SKIRVKVHA-GDTRYVFIGQDTSMRDFCQQIKEKFGVrn-nFKVEFKDD----GDMITMADQDDLDMAIDTaksmaRKEN 511 Phaeosphaeria n...
EDR11540     459 TLIRVKLHYqDDTRGMTLTPDTPFADFMDKVTAKFGKqingLGLKFKDEd---GGKVTLRDESDYELAIETar--eSAKG 533 Laccaria bicolo...
BAF36501     507 QDVAKMEIWIF 517 Epichloe festucae
XP_001240705 528 NDMGKLELWVS 538 Coccidioides immitis RS
BAE65134     320 SEMGKMEIWVE 330 Aspergillus oryzae
XP_001536353 535 LDMGKIEIWVQ 545 Ajellomyces capsulatus NAm1
XP_384299    497 TETGKMEIWIL 507 Gibberella zeae PH-1
EAT84610     512 SDMAKLEVSLP 522 Phaeosphaeria nodorum SN15
EDR11540     534 KPEGRLELWCM 544 Laccaria bicolor S238N-H82
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