Conserved Protein Domain Family
PB1_MUG70

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cd06409: PB1_MUG70 
The MUG70 protein is a product of the meiotically up-regulated gene 70 which has a role in meiosis and harbors a PB1 domain. The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 interaction, which involves heterodimerization of two PB1 domains, is required for the formation of macromolecular signaling complexes ensuring specificity and fidelity during cellular signaling. The interaction between two PB1 domains depends on the type of PB1. There are three types of PB1 domains: type I which contains an OPCA motif, acidic amino acid cluster, type II which contains a basic cluster, and type I/II which contains both an OPCA motif and a basic cluster. Interactions of PB1 domains with other protein domains have been described as noncanonical PB1-interactions. The PB1 domain module is conserved in amoebas, fungi, animals, and plants.
Statistics
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PSSM-Id: 99730
View PSSM: cd06409
Aligned: 13 rows
Threshold Bit Score: 109.711
Threshold Setting Gi: 3183377
Created: 28-Feb-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183377   575 FTIKYRSi--AGRVHRLRldg-inSVSDLRTAVEEREKEq-------------------lVTLTYIDDEGDVVELVSDSD 632
gi 126275953 463 FKFKSPAi--EGRVHRISira-seGLDKLRALMDAKLHTkdfqklkv-----skdnsdelYAISYVDDEGDIVSITSDND 534
gi 160703532 478 FPFKFKAp--SGRVHRLQvta-saGIEELIANVASKLGSeveaiggtpt-fefgkislsgFALSYLDNEGDTVSITTNDD 553
gi 50550993  445 FQFKFKSp--SGRNHRLTvvp-naGVTALRTSISDKLSVgdvel------------vtqnYAISYIDDEGDIVAITSDQD 509
gi 115487552 457 FAFKLQDq--KGRVHRFTcg--seSLNELASSIKQRLSItde---------------egiMQLLYEDDEGDRVLLTTDAD 517
gi 149239558 506 FVFKFRSpghIGKVHRVAlay-gdGIEKLKELIGAKLLAkdfealgv-----nrsvkegtYIVSYLDDENDIVSITSDYD 579
gi 168002427 384 FKLKLSAy--DGKPHHYRfncgseSLTELMSTIAQRVGDdidl--------------thlPRLMYIDDEGDKVLLATDSD 447
gi 164651834 500 YVFKFRTp--SGRTHRFQar--hdDVEHLREIVSGKLATdpfftefqpknedspkpdpidFHLSYTDADGDTVLITSDDD 575
gi 115442383 442 FSFKLQDr--KGRMHRFScv--seSLDELVSAVSYRLGMek-----------------ekINLLYDDDEGDRVVLTTDGD 500
gi 75265956  409 FAFKFEDr--KGRVQRFNst--geSFEELMSVVMQRCEAds------------------gLQIMYQDDEGDKVLISRDSD 466
gi 50302383  493 HSFKFKTl-tNNKTHRVSlrp-ieGVSKLVELIGEKLGGsd------------------dVEILYVDDENDLVSITHDQD 552
gi 75264250  414 FAFKLQDk--KGRMHRFMce--tqSLTTLITAILQRMGDdiep--------------dnlPQIMYEDEDNDKVVLASDND 475
gi 168028206 360 FAFKLKVnshNGKVGHYRfncgseSLKNLMTMIVQRVGDdidr--------------thlPLLMYVDDEGDEVLLATDSD 425
                         90       100
                 ....*....|....*....|...
gi 3183377   633 LREAILLarrrGLPRLEVRGVAA 655
gi 126275953 535 LVECIAIntrlDNDKADLYLHNP 557
gi 160703532 554 LVEAISLsrlaHREKVDLFVHDP 576
gi 50550993  510 LLDAVSItrraGLEKADLFIHHP 532
gi 115487552 518 LAGAVLHakssGLKVLKLHIDLS 540
gi 149239558 580 LLECVRVnrklGKEKADIYLSSL 602
gi 168002427 448 VVAAVNVarisGWKALTLHLEES 470
gi 164651834 576 ITDAVKIartaGTDRVVLFVQGG 598
gi 115442383 501 LSAAIQHarsaGWKVLRLHMDEP 523
gi 75265956  467 LVAAVTFarslGQKVLRLHLDFT 489
gi 50302383  553 LIDCVLVhknmNLDKIDLLVHYR 575
gi 75264250  476 LGAAVEHaksiGWKGLKLHLDYT 498
gi 168028206 426 LVAAVNFarisGWKVSLESILKH 448
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