Conserved Protein Domain Family
PB1_UP2

?
cd06410: PB1_UP2 
Uncharacterized protein 2. The PB1 domain is a modular domain mediating specific protein-protein interaction which play a role in many critical cell processes such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 interaction, which involves heterodimerization of two PB1 domains, is required for the formation of macromolecular signaling complexes ensuring specificity and fidelity during cellular signaling. The interaction between two PB1 domain depends on the type of PB1. There are three types of PB1 domains: type I which contains an OPCA motif, acidic aminoacid cluster, type II which contains a basic cluster, and type I/II which contains both an OPCA motif and a basic cluster. Interactions of PB1 domains with other protein domains have been described as noncanonical PB1-interactions.
Statistics
?
PSSM-Id: 99731
View PSSM: cd06410
Aligned: 27 rows
Threshold Bit Score: 103.454
Threshold Setting Gi: 147810341
Created: 28-Feb-2008
Updated: 17-Jan-2013
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116787206  35 LCRYGGrilprpGDGKLRYAGGNTRVVAASRsiGFADLIAKMSKVFGSsa---vlLKCQLPSEDLd--aLVSVKSDEDLE 109
gi 147845721   9 LCNFGGef--trQLGKLSYMGGKTRLVLVDRsvSFDELRSKLSQLTCAcpf-sieIKYQLPDESLes-rLVSVECEDDVV 84
gi 50428645    4 LCSHGGrlvpcgPGGGLRYVGGETRALAVPRgaPFRELTARLAEKAGAggdavtaVRYRLADGGLdedlLVSVTSDEELA 83
gi 116788887  24 LCSYGGkilprpSDGQLRYVGGETRLVTVDRsiTFRDFMKKLEDIFETmn---viIKYQLPTLDLd--iLISVICDEDLQ 98
gi 18087533    9 ICQSGGefv-tiKDGSLSYSGGDAFAIDIDQntSMTDFKSELAENFGFgle-amtLKYFLPGNKKt---LITISKDKDFI 83
gi 75264880    9 ICMSGGefq-teKGGSLSYKGGDAHAIDVDEqmKFIDFISEIGEMFNCdvr-tvsLKYFLPDNKKt---LISISNDKDLK 83
gi 125584092  44 MVSYGGriqprpHDHQLSYVNGETKILSLERplRFADFAARLAGLAGSpgd--fcVKYQLPGEDLd--aLVSVTNDEDLE 119
gi 125594311  46 LCSFGGrimprpSDGALKYIGGETRVLAVPRsiPFSDLKKKVEEMFRTev---aaIKYQLVAEDLd--vLVSVTCDEDLT 120
gi 115453433  50 ICNFGGrflprpSDGQLRYVGGERHLIKISRdiSWKELICKTSKLIRRah----mIKYHLPGEPMn--mLISITCDDDLR 123
gi 115444765   9 VLQVGGefk-tdDDGQMSYSGGEAHAMHVKSdwTFKTFKHEISSTLNNlkldsyvFKYFLPRNNKt---LISISNDKDLK 84
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 116787206 110 NMLEEYdrvg-------------areGLSKVRAFLF 132
gi 147845721  85 AMMSEFe-------------------ASQRIQVYIF 101
gi 50428645   84 HMRDEYdrlr-------------atrPSASFRVFVS 106
gi 116788887  99 NMMEEYdryds----------hkesgPCPRVKAFLF 124
gi 18087533   84 RMVNFSs-------------------DAGTVEIFVI 100
gi 75264880   84 RMIKFHe-------------------NSNTADVYLL 100
gi 125584092 120 HLVLEYdrlhllrpapgsgggssrggSTPRLRVFLF 155
gi 125594311 121 HMLDEYdrfea----------krspsASPRFRVYVF 146
gi 115453433 124 NMIDECivl---------------erTKVLLTVYLF 144
gi 115444765  85 RMVEFHa-------------------ESETTYIYVM 101
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap