Conserved Protein Domain Family
PB1_p51

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cd06411: PB1_p51 
The PB1 domain is present in the p51 protein, a homolog of the p67 protein. p51 plays an important role in NADPH oxidase activation during phagosytosis. The PB1 domain is a modular domain mediating specific protein-protein interaction in many critical cell processes such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 interaction, which involves heterodimerization of two PB1 domains, is required for the formation of macromolecular signaling complexes ensuring specificity and fidelity during cellular signaling. The interaction between two PB1 domain depends on the type of PB1. There are three types of PB1 domains: type I which contains an OPCA motif, acidic aminoacid cluster, type II which contains a basic cluster, and type I/II which contains both an OPCA motif and a basic cluster. Interactions of PB1 domains with other protein domains have been described as noncanonical PB1-interactions. The PB1 domain module is conserved in amoebas, fungi, animals, and plants.
Statistics
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PSSM-Id: 99732
View PSSM: cd06411
Aligned: 4 rows
Threshold Bit Score: 127.316
Threshold Setting Gi: 118099133
Created: 4-Mar-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative
Feature 1:putative interaction surface of the p51 PB1 domain
Evidence:
  • None

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
Feature 1           #        #               #                                                 
gi 74759404  316 VTVQCAFTVALRARRgaDLSSLRALLGQALPHqaqlgqLSYLAPGEdghWVPIPEEESLQRAWQDaaacpRGLQLQCR 393
gi 118099133 355 LRVRCECTVVVRAGEvpSVPALRALLRERFGQqaergrLSYRHLDGk-eLGAVSGEEDLEKMWQQltdgrITLCCQDS 431
gi 149759089 289 ITVQCAFTLALKAPRgaDVSSLRALLSRALPHqaqqgqLSYRDPSDdghWVPLCGEEVLQRAWRDvaggpGGLRIQCR 366
gi 166233911 288 VTVQCHFTVPLKVPRgtDLSSFRTLLSQALLQqtqkgqFSYKARGEdraWVPISTEDSLQSVWRNvpvspRGLQLQCR 365

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