Conserved Protein Domain Family
GH25_CH-type

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cd06412: GH25_CH-type 
Click on image for an interactive view with Cn3D
CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme (acetylmuramidase) and diacetylmuramidase activity. The first member of this family to be described was a muramidase from the fungus Chalaropsis. However, a majority of the CH-type lysozymes are found in bacteriophages and Gram-positive bacteria such as Streptomyces and Clostridium. CH-type lysozymes have a single glycosyl hydrolase family 25 (GH25) domain with an unusual beta/alpha-barrel fold in which the last strand of the barrel is antiparallel to strands beta7 and beta1. Most CH-type lysozymes appear to lack the cell wall-binding domain found in other GH25 muramidases.
Statistics
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PSSM-Id: 119374
View PSSM: cd06412
Aligned: 16 rows
Threshold Bit Score: 293.844
Threshold Setting Gi: 40739237
Created: 30-Aug-2005
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
active site
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            #                       #  #                            # #                 
1JFX_A         5 VQGIDVSHWQGSINWSSVKSAGMSFAYIKATEGTNYKDDRFSANYTNA---YNAGIIRGAYHFARPnassGTAQADYFAS 81
gi 126597      2 VQGFDISSYQPSVNFAGAYSAGARFVIIKATEGTSYTNPSFSSQYNGAttaTGNYFIRGGYHFAHPgettGAAQADYFIA 81
gi 40744608   17 VQGFDISHYQETVDYQGAYDSGARFVMIKATEGTSYTDPKFSTHYSGA---TSAGLIRGGYHFAQPgsssGADQASYFIE 93
gi 46098392   31 IPGFDVSGYQPNANMNGAYANGARFVYIKATEGTTFKSSSFSSQYNAA---TNAGLIRGAYHFARPdsssGATQARFFLN 107
gi 9909922    70 TEGVDVSSHQGNVAWSTLWNSGVKWAYAKATEGTYYTNPYFAQQYNGS---YNVGMIRGAYHFATPdttsGATQANYFVD 146
gi 50843125   81 PEGMDVSSHDGNVDWPAKVSSGMSFAWVKATEGTSYQNPFYASQYNGS---QSAGLIRGAYHFALPsnssGQAQATYFSD 157
gi 116671220 155 VKGLDVSAYQSTVDWLQQWNMGARFAYVKASEGNYYTNPSYSSQYNGS---RNVGMIRGAYHFAIPnwssGADQARYFVQ 231
gi 2327014    34 ALGIDVSNHNGEVDFAKVGADGRDFAFVLATDGESFTSDLFDSQYSGA---GEAGLYRAGYHFARPdg-sATKQADRFLK 109
gi 134101847 157 AEGIDVSNHNGSIDWRKVAADGKQFTFVLATDGTSFTNPRYSEQYHGA---KEAGLIAGAYHFARPdk-sAEAQADRLLA 232
gi 134100299  75 VAGMDVSGHQGVVDWRAAWDAGARFAYVKASEGVGFRNKHFPQQYDGS---RGVGMVRGAYHFALPdrssGAEQAHFFVD 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                        # #                                               #             
1JFX_A        82 NgggwsrDNRTLPGVLDIEhnps----------gamCYGLSTTQMRTWINDFHARYKARTTrDVVIYTTASWWNTCTGSW 151
gi 126597     82 HgggwsgDGITLPGMLDLEsegs----------npaCWGLSAASMVAWIKAFSDRYHAVTGrYPMLYTNPSWWSSCTGNS 151
gi 40744608   94 HgggwsgDGQTLPGMLDLEa---------------gCYGLSTSAMSSWIKDFGETYKAATGrYPMIYTTTSWWQECTGND 158
gi 46098392  108 NgggwsaDGRTLPGALDLEsssg----------vatCYGLSKSQLVSWIQDFGNTYHASTGrYPTLYCSSGWWNQCVASS 177
gi 9909922   147 HgggwsrDGKTLPGALDIEwnpy----------gatCYGKSQSGMVSWIRDFLNTYKARTGrDAVIYTATSWWTQCTGNY 216
gi 50843125  158 HgggwseDGYTLPGVVDLEynpy---------genaCYGLSQTAMASWIRDFVSTYQERWGrAPMIYTSTSWWNMCVGSA 228
gi 116671220 232 NgggwtpDGYTLPPVLDFEfnpyegrtingfyfgntCYGMSPAQLTSWVRDFGNTMLAMTGrLPMIYTNTSWWKLCTADA 311
gi 2327014   110 Tvgs-tnDGRTMPPVLDMEanpn----------gatCYGLDDAQMEEWIKSFVGRVKEKTGrEAVIYTSPSFWKECTGNS 178
gi 134101847 233 Tady-qpDGRSLPPVLDLEvdpk----------gggCYGLSVQEMHQWTDTFNRKIKDATGkDPIIYANPSFWNQCMGGT 301
gi 134100299 152 NgggwvpDGHTLPGALDVEhnpy----------ggaCYGLPPEGMSRWIAEFSDTYRARTGrFPAIYTTTRWWQQCTGGN 221
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
Feature 1                  #                         #              #           
1JFX_A       152 NGMaa-kSPFWVAHWgvs----aptVPSGFPTWTFWQYSATGrvggvsgdVDRNKFNGSAARL 209
gi 126597    152 NAFvn-tNPLVLANRyasa---pgtIPGGWPYQTIWQNSDAYay-----gGSNNFINGSIDNL 205
gi 40744608  159 SGFg--eYPLVVARWgss----vgtLPASWSTHSFWQNADTYef-----gGDSEVWNGSEDSL 210
gi 46098392  178 AFAs--nYALWVANYgvs----spkIPTGFNYYTFWQYSDNGpy-----pGDSDTFNGSLDGL 229
gi 9909922   217 GGFaa-sNPLWIARYast----vgtLPAGWGYYTMWQYTSSGpt-----vGDHNKFNGALDRV 269
gi 50843125  229 ASDitavAPLWIARYsst----vgeLPSGWDAWTMWQYSDTG--------YDHDRMAGTREDL 279
gi 116671220 312 AGFg--dYPLWVAAYpssatndagpVPSSWDTYSMWQYSSTGpy-----aGDSNVWNGDYASL 367
gi 2327014   179 EAFt--tNPLWTAEWdvd----kpsKVGGWPAHTFWQYSNSGkvdgvdgaVDVNRFNGGTAEL 235
gi 134101847 302 ADYg--dHPLWLASYgvs----npkVPAGFDNWDFWQYTDSGkvagiskpTDLNQFQGGIERL 358
gi 134100299 222 PSFga-nNPLWLARYape----pgaLPAGWRFHTIWQFADRGvf-----pGDQNTFNGGPEQL 274

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