Conserved Protein Domain Family
GH25_muramidase_1

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cd06413: GH25_muramidase_1 
Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues.
Statistics
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PSSM-Id: 119375
View PSSM: cd06413
Aligned: 19 rows
Threshold Bit Score: 271.075
Threshold Setting Gi: 169836239
Created: 30-Aug-2005
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
active site
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              #                        #                            # #                 
gi 23348296   68 YPIHGTDVSKYQSDVDWsav-rasGISFAFIKATEGGDRVDERFNEHWSGTREARLPRGAYHFYYFCRPAIEQARWYIQN 146
gi 50083506   54 YTVRGFDVSHHQGNIDWaki-spqKFQFVYLKATEGGDFQDPKFQENWLKAREYHFHVGAYHFYRLCRDGKTQAENFIAT 132
gi 32263061   25 YPIKGVDVSAHQGQIEWkil-keqGISFAFIKATEGSKWVDKRFAYNFENAHNQGLFVGAYHFFSFDSSGLTQAENFIRN 103
gi 47528786   39 YEIKGVDVASYQGDIDWrel-ekqNMKFAFIKATEGSAFVDKYFSKNWTNANKTSMRVGAYHFFSFDSKGETQAEQFIRN 117
gi 13476430   18 YPVRGIDVSHHQGQIDWrrv-aadDVAFAIIKATEGGDHVDRAFATNLREARAAGIAVGAYHFFTFCRPGADQAKNFISV 96
gi 45656952   44 YPIRGIDVSNHQGKIDWtlv-pksEISFVYIKATEGRDFKDKSFHLNWKKAKANGFFVGAYHFFTLCKSGKEQAENFIST 122
gi 116251310  40 YPIQGIDVSHHQGDIDWkvvasqpNVRFAFMKATEGGDHRDSKFADNWQRAGDAGVVRGAYHFFTFCRPGKDQAQNVLAT 119
gi 118591108  39 YTIRGIDISHHQGDIDWaqv-aadDVAFVYMKATEGGDFKDRAFARNWAGAGGAGLARGAYHFFSLCKSGREQAENFLSV 117
gi 114798870  37 PGAEGLDLSHHNGAVDWprl-staGLSFVYLKATEGEGHVDTRFQENWLGAWRHHWQAGAYHFYLLCQDGRRQADNFIRQ 115
gi 160938789  71 YPVRGVDVSHYQGEIDWkvl-grqDIDFAYIKATEGSSHVDEKFYQNWSESALSGLAVGAYHFFSFDSSGKDQLAHFIQC 149
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                      # #                                      #                      # 
gi 23348296  147 VPreq--saLPPVLDMEWnphsptcklrpnaavvRREMRTFLQAVEKHYGKRPVIYTTVDFFDDNdlrq---lseyPFWL 221
gi 50083506  133 VPkki--daLPPVIDLEYdancint---ytkeqlLEQIKVTHDLLKAHYGKQPIFYVSKNFYHIVlmgs---fqnaPLWI 204
gi 32263061  104 VQndkspkrLPPVIDIEFygtkasn--ppsaqsvYKELDKLLLHLEQYYGVKPIIYTTPSFYDMYlrgr---ykdnPLWI 178
gi 47528786  118 VPkyk--qaLPPVIDVEFyankkdn--ppkredvTKELSVMIEMLEKHYGKKVILYATQEAYDLYikda---ypqcDIWI 190
gi 13476430   97 VPhdq--plLPPVVDVEFggncpqr---pspeqlNAELQAFLGPVEAAFGKTAIVYLTDEAEAAYarqi----aarPLWL 167
gi 45656952  123 VPkei--dsLPPVVDLEFlgncker---ssmkdvSNEIQEFLNRVDSHYGKKTILYLTYEFIDRYigpn---fqdhPIWI 194
gi 116251310 120 VPkeq--gtLPIAVDLEFvgncnki---ptleemVAEVNAFFTELKGTFPEKPIFYVTQEFFDQYlkgnesrfpdhYLWL 194
gi 118591108 118 LPqds--dmLAPVVDLEYtgncarr---ppaeevLQEISDFAALVEQGRGKQVILYVPENFYLDYlkgr---glnrRLWT 189
gi 114798870 116 VEvrs--gaLPPAVDLEHahncapq---nsrgetLADLKVFLAALEAEYGAVPVIYTTPAFHAEWlageg--fdahPLWV 188
gi 160938789 150 LPdre--gmLPPAVDVEFygdkaan--ppnpadvEQELGALLEGLEAQYGIVPVIYATEESWNLYirgr---fdryPLWI 222
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
Feature 1                                   #                 #      
gi 23348296  222 RSvaghpde--------kygphpWTFWQYTGTGSIPGi---RGDADINTFAG 262
gi 50083506  205 RDydgkpe---------lkddrqWLFWQYTSKSSIKGi---EKPVDLNVYAG 244
gi 32263061  179 RSvffaphslwarlfnvyfdknsWIFWQYNPKGVLKGysgaEKYIDLNVFNG 230
gi 47528786  191 RSvltkps---------lsderkWTFWQYTNRGKLSGyngkEKYIDLNVFYG 233
gi 13476430  168 RSllmep------------drhdWVYWQYHNQGRVDGi---QGNVDLNVLQG 204
gi 45656952  195 RDlfkhpn---------tfsnqrWILWQYKSRGSLPGi---SGPVDMNVLNG 234
gi 116251310 195 RSvfrepr---------qeecshWSIWQFADNGTLDGi---QGPVDLNALCP 234
gi 118591108 190 QSiwhsp-----------gyvsdWTLWQYHDRGTIKGv---SGDVDLNVLHP 227
gi 114798870 189 RSlegp-------------prlpYAIWQYSMKGRVPGv---TGNVDLNRAAE 224
gi 160938789 223 RNvktkpr----------tegepWLLWQYTNRQRLGGyegeETFIDMNVYCG 264

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