Conserved Protein Domain Family
GH25_LytC-like

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cd06414: GH25_LytC-like 
The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a C-terminal glycosyl hydrolase family 25 (GH25) domain and an N-terminal choline-binding module (CBM) consisting of eleven homologous repeats that specifically recognizes the choline residues of pneumococcal lipoteichoic and teichoic acids. This domain arrangement is the reverse of the major pneumococcal autolysin, LytA, and the CPL-1-like lytic enzymes of the pneumococcal bacteriophages, in which the CBM (consisting of six repeats) is at the C-terminus. This model represents the C-terminal catalytic domain of the LytC-like enzymes.
Statistics
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PSSM-Id: 119376
View PSSM: cd06414
Aligned: 44 rows
Threshold Bit Score: 196.635
Threshold Setting Gi: 15903474
Created: 31-May-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
active site
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            #                             #                                  # #        
gi 15903474  302 KKIIDISEHNGRIn----DWKKVIDenKVDGVIVRLGYSgk-------eDKELAHNIKELNRLGIPYGVYLYTYAenetd 370
gi 160944986 277 TFGIDVSKYQSGL-----DWNKIKKs-GVSFVIIRIGYRgygaagnlvkDPMFEEHFTNARNAGLKVGAYFFTQAvneae 350
gi 116630110   2 IPGIDISEWQGHV-----DFNAVKAs-GVKFVLIRAGYGrsa----sqvDHYFAEHYAQAKAAGLQVGAYWYSYAvspad 71
gi 169335729  80 VNGIDVSVWNNNI-----NWTKVKNa-GIKYVFIRVAARgygksgtifdDSMFVKNINGAKAAGIKVGVYFFSQAitkae 153
gi 160937853 100 FRGIDVSRWQGDI-----NWSQVAAd-DVSFVMLGTRSKga-------vDPYFHRNIQQASAAGVKVGVYIYSLAmtpem 166
gi 160936922 105 EKGITVTKYQNRAnengiDWSRVASd-GVSFAMIRVGYYkd-------kDPYFDRNVTEAFANGIHTGVFFYTQAldvqt 176
gi 169824069 574 QQGADLSKFNRYV-----DMRLAKKn-GMDFVILKAGSGys------geDPKFQQNYNNAKAAGLNVGAYWYSYAvnvee 641
gi 160893556 162 IDGIDISRWQGKI-----DWKKVKAd-GVKFAIIRVALRttesg-vleaDALYKENLQGAIDAGLDVGVYIYSQAistae 234
gi 167772010   5 IKGIDISSHQGDI-----DFERVKAd-GVRFVIIKAGQGlr------emGTFRQKYLPAVLAAGLDWGAYWWSDAvtvae 72
gi 163816068  86 QKGIDVSEWNGSI-----NWKKVKAs-GITFAFIRVGGRyygsg-kfyvDANYRENLKGAIAAGLDVGVYFYSQAinsse 158
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                 # #                                            #       
gi 15903474  371 AENDAKQTIELIkkynmnlsYPIYYDVEnweyvnksk-----rapsdtdtwVKIINKYMDTMKQAGyqNVYVYSYRSLlq 445
gi 160944986 351 AQEEAEGCNWALngr--mldYPIFYDTEastapggtgr----adglgaedrTKCAIAFCERVKELGy-TPGVYASTTWyr 423
gi 116630110  72 AANEARACLTVLgnr--hfdYPIYFDLEekwqfa-----------ngrnfcDSLVKSFCSVLEQNGc-YAGLYISRSPlq 137
gi 169335729 154 ARQEANYTLNKIkgy--kmdLPVVMDYEysggssgrlt----qaklsktaaTNICMEFLNTIKAAGy-TPMLYANYSMln 226
gi 160937853 167 AVEEANFVLNLIhdy--pvsYPVAFDMEdstqgt-----------lskdelAAIANAFCGRISEAGy-YPVIYANDNWla 232
gi 160936922 177 AIDEANFVLKVIkdf--pisYPIAYDVEsqhlldn---------gltrqqiTDNVNAFCKTISDAGy-HPVVYGNNEWlt 244
gi 169824069 642 AKEEAVRYMKILgkk--qfeYPVYLDFEdpsqrk-----------ipketkTDMAIAFMSILEKNGf-YTGLYSSGSWin 707
gi 160893556 235 AKAEADFTMNLLkgy--dinLPIVMDFEyytgntgrla----rahlsvaqaTTICNAFCKEVESKNy-TAMVYANKSLlt 307
gi 167772010  73 AQKEAAAFVRALdgl--rptYPVYMDQEyespcgnaw-----gvgkgkqlrTDMAKAFLKVLEDAGy-YAGLYASTNWlq 144
gi 163816068 159 AKAEAAYTMNLIsgy--ninLPIVMDYEyaweegvgitgrlynanlsksaaTTVINSFCSAVEIRGy-VGMLYASKSVit 235
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
Feature 1                      #                         #                  #     
gi 15903474  446 trlk-hpdilkHVNWVAAYtnalewe----npyysgEKGWQYTSSEYMKGIqg----rVDVSVWY 501
gi 160944986 424 krvdyntlrsrYTIWNAHYgvss---------spigCDLWQGTEKARINGYsg----eLDANISY 475
gi 116630110 138 nyis-ptvaqrYAIWIAEYgprcn--------yggnYGIWQHYSTGSVPGVsg----nCDLDYAY 189
gi 169335729 227 yslnketidakYAVWLAHYststs--------yngdYTFWQYSSDGKVSGIsg----rVDMNFWY 279
gi 160937853 233 nkld--mskmnYPVWVARYsakp---------ayqnPVMWQATSTGAVNGIsg----nVDIDFQF 282
gi 160936922 245 rnmd--tgqipYDIWYARYgtvn---------sypnRTIWQCTDTGSVDGIng----nVTIELAF 294
gi 169824069 708 nqfe-rerlkdYDIWIAHWhvtnpn------cytpdYGMWQFTNKSKIKGVpdtgeggVDMNYSY 765
gi 160893556 308 ndvnsnaiaknYQIWLAQYpgwdsatgsihasfdgkYSYWQYTSSGSVDGIag----rVDMNFRY 368
gi 167772010 145 ywvd-dkqleaYDKWVAQYaekctyt---gsygmwqHHGDARGFVGRVDGIsv----pVDINACY 201
gi 163816068 236 ddmnisninnkYPVWSALYsdsdtd------slkakHSYWQYSEDGTVAGIgr----aTDMNFRY 290

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