Conserved Protein Domain Family
GH25_LysA-like

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cd06417: GH25_LysA-like 
LysA is a cell wall endolysin produced by Lactobacillus fermentum, which degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. The N-terminal glycosyl hydrolase family 25 (GH25) domain of LysA has sequence similarity with other murein hydrolase catalytic domains while the C-terminal domain has sequence similarity with putative bacterial cell wall-binding SH3b domains. This domain family also includes LysL of Lactococcus lactis.
Statistics
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PSSM-Id: 119379
View PSSM: cd06417
Aligned: 8 rows
Threshold Bit Score: 281.637
Threshold Setting Gi: 116490316
Created: 13-Jun-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
active site
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            #                      #                            # #                     
gi 45272226    2 LKMVDVFSgsprs--fatlpETDITMVKATQGIgYVNPACNIDYANAKAAGKLLGLYHYCag----gnPIAEADYFINNI 75
gi 4210750     1 MNGIDISSyqael--nagivPSDFVIIKATEGTnYINPTWEEQAGQVIQTNKLLGFYHFAsv----gnPIAEADFFISVV 74
gi 29376595    1 MNGIDISSwqsninvgkegvPADFVIVKATGGTgYINPDCDRAFQQAISSGKKVAVYHFAnevglegtAEQEAEFFLKNI 80
gi 23335574   34 MVGIDVSGwqasn--vtctaSYDFAVVKVSQGVgFENSSWRTQAKCVTDRGKSLGLYHYAgg----nnAASEADYFVGRA 107
gi 154487272  51 MNVIDVSGwqsad--vtrvvDADAAVVKVTEGGgYVNPSWRSQIDWARQTGKACGGYHYAdg----gnVTAEVNHYLNQF 124
gi 163816450  12 MDGIDISAwqdti--ditkvPCDFVIVKATEGTdYKNRFFAKHCDQAMKAAKLLGAFHYAng----gdPHSEAEYFLAYS 85
gi 171742577  33 MNGIDVSGwqapd--itsvvDADFAIVKVNQGT-WLNSSWRTQAANAVNTGKELGLYDYAsg----mnATAEADAFVDRI 105
gi 116490316 464 MNGYDESSyqsgi--sngsiSGSFVIVKATQGTdYVNPAEASEVASTVAAGKKLGLYSYAet----gnAISEAEYFVSNI 537
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                   # #                                #                     #           
gi 45272226   76 KNYVGEAVLAVDWEgyqns--swgnYNYVRQFVNRVHELTGVWCMVYVSQSEirqvan---cindcpLWVAYYkysqpln 150
gi 4210750    75 KNYIGKAVLVLDFEagai---nawgNVGARQFLNRVKEKTGINPMIYMSSDVtrqfnws-tisstnpLWVAQYasmnptg 150
gi 29376595   81 KGYIGKAVLVLDWEstn-----kgdVAWAKRWLDYVQGKTGVKPMFYTYTNVlqsynfssiakadygLWLADYgannpqg 155
gi 23335574  108 RDYIGRAVLVLDWEsyqna--qwgnSDWVRRFVQRVHTLTGVWPMVYVQASAlgqipgd--vrancgLWVAQYasnaptg 183
gi 154487272 125 NGYVGQCVLALDWEsygnh--awgnGDWVRQWVNQVYSRTKVWPMVYVQDSAvyqipsd--vrshcmLWKAQYasmnatg 200
gi 163816450  86 KKYVGKAILVLDWEgqnnpqfgrsdRAWCKEWCDYVYRKTRVKPLIYIQKSAmdnvk-----nlgyrLWVAQYpdyeqtg 160
gi 171742577 106 GGYVGKAMLVLDWEsyqns--afgnSSWIREWVNRVHERTGVWPVVYCSKSVvsqipsd--vrahcmLWAAQYannnatg 181
gi 116490316 538 KSYLKDNPILILDWegsa---ltqgPTWAKQWLDEVHNLTGIRPLIYMSKSVtseynws-svapnygLWVAEYattastg 613
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
Feature 1                             #              #           
gi 45272226  151 wdyq--gagfniapwevFTIHQFTGs--------dMDRNMVNTTKEGW 188
gi 4210750   151 yqsepwtdgkgygawssAAIHQYSSagslsnwsgnLDINLAYINANQW 198
gi 29376595  156 ysqp---tpppvpywnfISMYQYTSngqlpgwngrLDLNVFFGDRSMW 200
gi 23335574  184 yqs-----rpwnyaiygEAMRQYTSngwvngyngpLDLNYFRGDASQW 226
gi 154487272 201 wqs-----tpwnagskgEGMVQYAStgyln-gvgpLDLNLFFGERDAW 242
gi 163816450 161 yqe-----hpwnegqydCSIRQYTSvgrlpgyegnLDLNKSYIDKATW 203
gi 171742577 182 yqs-----spwnagssgEGMLQYSSsgyln-grgpLDLNKFFGDRTAW 223
gi 116490316 614 yqsnpwtnnddygawstPTIFQYTDngslsgyggaLDLDLFYGDFEDW 661

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