Conserved Protein Domain Family
GH25_BacA-like

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cd06418: GH25_BacA-like 
Click on image for an interactive view with Cn3D
BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of Bacillus subtilis. BacA has a C-terminal catalytic glycosyl hydrolase family 25 (GH25) domain and an N-terminal peptidoglycan-binding domain comprised of three alpha helices which is similar to a domain found in matrixins.
Statistics
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PSSM-Id: 119380
View PSSM: cd06418
Aligned: 28 rows
Threshold Bit Score: 149.793
Threshold Setting Gi: 118473869
Created: 28-Jul-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
active site
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                       #                            #                                 # 
1SFS_A        18 LYFQSNAMARGIWGVDSAqvvtdq---lfqcvrTELGYPKFWGRYLSEVpnv-----seGLTRDEIVRIRNYGVKVLPIY 89
gi 118473869  25 VLAGLGAGVSAAPASAAApqlidfaaaqipaehIKAAGYAGVINYVSTSrpgss-fgakPITRPYAESLTRAGLVIVSNY 103
gi 20804242   29 TARADDKTPRTYSAVDCYsypgdd----aikqlREQLKFDIVGFYLNHVrgt----pdlTWTYDRRSDLAMSGWGFFPTY 100
gi 169350988 270 LMSSNGDTSRPAIGCDTAtkltp-----tqiqtLVDNGYRYVGRYVSNTpggt---ldkALTKTEVNNILNAGLKLFLIF 341
gi 169635868 282 LLSSAGNTDRAASACDMAtqltk-----qqaqlIKDNGYSIVGRYLTGSvgvgankkdkNLTLEEIQAITSVGLSIFPIY 356
gi 89097510   35 SGGNETDPESVVWGVDSAslttee---lfscvrDNFGNPQIWGRYLGTKegv-----sqGLTKEEAAFLQSNNAGILLIN 106
gi 15614778   95 GQRDGDDLPEIVWGVDSVnvtdss---fldcvtTNFGSPTIWGRYLGDKedv-----syGLTPEEIELLHDHDISILIIY 166
gi 94969898   38 GLAVAQESQPYHLGFDRNvypg-------ddllPALHKTFEWTGYWLNNppg----anrNTWAGKREMMKAAGFGFAVLY 106
gi 29830082    3 ATTWPAQRTFTGRAFDTCaapsl-----samkaWHTGFYGAAAVYVGGKnrgc---gqpNLTASWVKSVSTLGWKLIPLY 74
gi 119718549  68 AANPVTPGDFTGFGFDQChtpeqr----kmnrwLQSSPFLAVGIYISGDsrac--reqpELTPTWVRTQLAKGWRLLPIT 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #                                                            # #                
1SFS_A        90 Naf-------------------------reAVGYANGQVAARNAVFHARRLGipknkLLFANIEDFfa-------vdAAW 137
gi 118473869 104 Qygkpgg-----------------tapsdfRRGAAGGVADAKTAWQLHTAAGgarnaPIYFSVDEDidrqt-wnnlaLPW 165
gi 20804242  101 Iggdl----------------------slmVSKPELGIKHGLEAAQFMTDVGfgqgsVVYLDIEKPage-----lqlSPY 153
gi 169350988 342 Qesgn----------------------sveRFNFSTGIQNATSAIAAVKNLGyssfvPIYFAVDFDatdtq-iksniLPY 398
gi 169635868 357 Qdggw----------------------eesYFNEGNGLRDGSLAHNAAFKLGfpygaTIYFAVDVDildgn-ipgtvLPY 413
gi 89097510  107 Nqf-------------------------tdATGMENGTEIGNLGIQLASELGvpegtAIFADIEPDyp-------vdSDF 154
gi 15614778  167 Nqf-------------------------idATGYETGVNEAEGALAFAEELGipegvAIFANVEPEyp-------vdGAF 214
gi 94969898  107 Ngrlyn--------------------elkgKNPAQIGQKDGRDAAARANAEGfragaIIFIDQEQGgrml----eeqQAY 162
gi 29830082   75 Vgaqppcqtg------------sspekitaSTAASLGATDAADAVAKASALGmkagsPIYLDMESYdvtdkacndavLTY 142
gi 119718549 142 LgpqascqprfprygddetiiprpganggySKAKKQGNAEAVKSVGVAADLGiapgsTLWYDLEGFdlrntrcresaLAF 221
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                           #                             #                              
1SFS_A       138 IAAWVETLYPTg--yRPGLYADPTKGdfaaayceavs-rnnqvavqavIWSAAprpgttkeqkap-----ryqpaappcs 209
gi 118473869 166 FRGINSVIGVQ----RTGVYGGVNVCq---------------------WAIEDgvigr--------------------sg 200
gi 20804242  154 LNNWIKAVKSRk--fYPGFYGSYSMAdwlknlssalwsvelpapvaavSYDSDdnptglitsrciatqylqkqklaiikg 231
gi 169350988 399 FKAIVDTIKKDandfQIGVYGTRNVCatvrdt----------ypevgrLFISDssygysg----------------nlgy 452
gi 169635868 414 IKKVKESLDANgm-yKTGIYGTRNVCqqaida-----------gfvehCFVSDmstgfsg----------------nlgf 465
gi 89097510  155 IRGYYGAMSESp--yEAGIYGVFSSNstlyaaynnaaadsaglkenviIWTAYpqagisteseap------ayspeapeg 226
gi 15614778  215 LAGWYDTLTEAn--yPPALYGLFDDDsnvtialeeareenetifeeliLWSNQpqvgitseenap-----dsfdvnapdg 287
gi 94969898  163 LHAWFDAVIAAg--fKAGVYCSGMAAegvvtakdih---dhaqgrkiaIWAYNdacspsrgcyfpk----nppspaksgi 233
gi 29830082  143 VRAFDKALHAKt--yRTGYYGFRSSSakavadat------drtdlpgnLWYALwdkq----------------------n 192
gi 119718549 222 LSGWTWQIHRLg--yASGVYSGASSGikmlddarvn--rpgqvvlpdqIWLARwdgkant----------------sssy 281
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
Feature 1              #                                    #    
1SFS_A       210 anVWVWQYGRdae--------------------------vcpVDTNLA 231
gi 118473869 201 tpGKAWAWQTrswskgkih--------------paavlyqhtIDTASN 234
gi 20804242  232 tpGGDGTYDLsrsl------------------------aadpSDTACI 255
gi 169350988 453 tmPKTWSFDQfatditig-----------------ngegkvtIDKVAV 483
gi 169635868 466 pmPKEWAFDQfyehs----------------------elgfpIDKVAV 491
gi 89097510  227 saVLGWQYGLdae--------------------------acnIDTNLF 248
gi 15614778  288 srPLGWQYGLead--------------------------tcnIDTNLF 309
gi 94969898  234 pyAEIWQYAQsprrgeakacpknynadgncyppelpvetkthVDLNTA 281
gi 29830082  193 ttTADWPFGAgqwtnhsrahqym------vnskesrggytitVDRDAW 234
gi 119718549 282 lrEDGWRPHArikqyqgghd-------------etwggvtinIDRNFL 316

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