Conserved Protein Domain Family
GH25_muramidase_2

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cd06419: GH25_muramidase_2 
Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues.
Statistics
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PSSM-Id: 119381
View PSSM: cd06419
Aligned: 9 rows
Threshold Bit Score: 214.568
Threshold Setting Gi: 58336941
Created: 7-Jul-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
active site
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                   #                       #                            # #             
gi 28377935   49 AVVSGFDVRGVAVSQNDGylDFAALQNDGLKFVYLHATQGASYTDDNFASNYERIVGTSLGVGVIHTFSFSSTAAAQADY 128
gi 116492382  52 LALAPYPVHGCVIDQENGiiDFNSLQKQHISFVYLNATTGATYFDDSFNTNYSRIQSTDLKVGIVHNFSFQKRPKAQLRF 131
gi 81429151   46 PNEQQYPVLGAQISQEDGyqDYQILKKESLKFVYLKATEGASYKDDNFDSNYSRAEGSGMSVGVYHFFSFDSSPEDQAQQ 125
gi 116494574  43 PDPQTYPVLGVRLDQTDGvqDFDSLRSSKVSFVYLKATEGSSYFDDNFNTNFNQAAGSRLSIGIYHVFSFETTPQAQAAQ 122
gi 116617641  48 AIPSGFSVQGVSINQTSNyvDFNNLASNGVSFVYMRTTSGSSVMDGGYKSSFSRAKSAHLKVGTIHVYDASVTAATQAQY 127
gi 116490488  92 KANLKKYALGTTLSSDQPytDYSYLKSQNIRFVYFRSTTGNSSFDNLFLTSIKSAKDAGLSVGSMTIYDPSITAYSAYLY 171
gi 116334164  49 QQLSNYPIQGVMINQDSGy-LDFQQLANREKFVYLQATSGATYTDDAYGDNFSRSQGADIAVGVVHTFSFTSSAEQQYRH 127
gi 58336941   38 PPSSNSSAIGIQLNQDVDyvDLHKLQSNGISFVYLKATQGRSYFDENYLSYRDQILGTKLAFGSMITYSNESTPLQHYRY 117
gi 42518735   38 PRGSNMSVLGIELDQTKDyiDLHKLEKNGISFVYLRSTQGKSYFDDNYLLYRDQIQGTNLNFGTIIAYSDETSNQEQYQY 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                        # #                                    #                    #   
gi 28377935  129 FEKTVGDSIGNLPIAIQVQyygdytdqtiavrksRAKLKALVTTLTQDynrSCVVWSTPAVakqivkp-alkdtdLWLDT 207
gi 116492382 132 ISQKVKSNTGQLPVVIRVSyygdynakrvdwkkaGPNLADLVKLLANYygqAVVIKTTPAIkrqldpt-yikqskFWLEE 210
gi 81429151  126 FIKSVGQDTGHLPIMVYLSyyndyaqkppakaktQRAIARFVTLINQYyhqDCIIGGAPALlkryvp--tkgtypLWQTT 203
gi 116494574 123 FTRQVGQNIGDLPIGIYLSyytekk---pstqwlTTQLQTFVTLVQQHyhrQVLLMGSPSIlkavqk--vdsqapRWVVS 197
gi 116617641 128 YIDNVGNNIGELPIAISVTadqis------tatsKQRLASLVQILASHynhDMIIYTTPNVqkklss--tisktkYWLIE 199
gi 116490488 172 FVRKVGKKVGNLPIAVYVTddsit-----ddnsiTNLLGLLQDLKEYYpnnSVIVRCDKTVydevhaklaslnlkYWLIE 246
gi 116334164 128 FRATVKEDSGTLPIMVAVAyygkynndnhqmamqGQKLKMLVQKLTQHysqGVIILATHQVldqfvhp-vlpalhYWVAD 206
gi 58336941  118 FFSQVGNNTGSLPILIEPInsrs--------kkyLRSMGQFTRMLEKHg-kSVIINIDYKYh------------nYFDAQ 176
gi 42518735  118 FLNKVGTNTGSLPVMIVPAashl-------tksyWKRMGIFAQMINNLg-kRVMIAGDYRYh------------nYFPEG 177
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
Feature 1                           #                #    
gi 28377935  208 akthq------qgrrVMFMHYSDravyrqngtrqeFAGILF 242
gi 116492382 211 pqikk------hnwrVQFVEYDAeqkfkndhsdleLPVSYF 245
gi 81429151  204 qqrpt------vgtkNGFWQYTTaskipggrddseYQLAVF 238
gi 116494574 198 dkkp--------ttsSGFWQYTSgarlpn-gphadYRAAVF 229
gi 116617641 200 dntkn------tdskNLFIQYDEdqtigsglkaikMPTTVF 234
gi 116490488 247 nnldg------lgseNQFVQYNAngkvgsgmrsfrLPLSVF 281
gi 116334164 207 grltg------qgaqVKFIEYDAngtmtqnaqshaVERAVF 241
gi 58336941  177 tkfmssdakspnklkYSFWRYTTngrvk---nlagLEKGVT 214
gi 42518735  178 trflytgaslkdrrhYAFWCYTQngrvk---nidnLERNVT 215

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