Conserved Protein Domain Family
M1P_guanylylT_B_like_N

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cd06425: M1P_guanylylT_B_like_N 
N-terminal domain of the M1P-guanylyltransferase B-isoform like proteins.
GDP-mannose pyrophosphorylase (GTP: alpha-d-mannose-1-phosphate guanyltransferase) catalyzes the formation of GDP-d-mannose from GTP and alpha-d-mannose-1-Phosphate. It contains an N-terminal catalytic domain and a C-terminal Lefthanded-beta-Helix fold domain. GDP-d-mannose is the activated form of mannose for formation of cell wall lipoarabinomannan and various mannose-containing glycolipids and polysaccharides. The function of GDP-mannose pyrophosphorylase is essential for cell wall integrity, morphogenesis and viability. Repression of GDP-mannose pyrophosphorylase in yeast leads to phenotypes, such as cell lysis, defective cell wall, and failure of polarized growth and cell separation.
Statistics
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PSSM-Id: 133047
View PSSM: cd06425
Aligned: 27 rows
Threshold Bit Score: 339.187
Threshold Setting Gi: 123402013
Created: 13-Dec-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:probable substrate binding site
Evidence:
  • Comment:Predicted GDP-glucose binding site based on similar proteins.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             ####             #                                                         
gi 24638016    1 MKALILVGGFGTRLRPLTLTLPKPLVEFGNKPMILHQVEALAAAGvtDIVLAVNYRPEIMVEALkkyekeYNVNITFSVE 80
gi 124808663   1 MNALILVGGYGTRLRPLTLTTPKPLINFCNKPIIEHQILHLAKCGikEIILAIAYKPTNITNFVkemekkYNVQIIFSVE 80
gi 19069594    8 VKAVILVGGYGTRLRPLTYTVPKPLVPFANKPILRHQIEALVKVGikEIILALNYYSEFIIREVrdysneLGISIVYSKE 87
gi 145512980   1 MKALILVGGYGTRLRPLTFKCPKPLVEFANKPILMHQIEALVKVGvqEIILAINYQPDTMKEQInklqdlYKVKIICSQE 80
gi 71031126    1 MKSVILAGGHGTRIRPLTLSVPKPLVEFCNCPVIEHQIKACKNAGfdHIIIAVTEYHNIIEPIKqla-ekYAIRIDFSVE 79
gi 159475619   1 MRALILVGGYGTRLRPLTLSCPKPLVEFANKPMIIHQIEALKVAGctEVVLAINYQPEVMLGFIqewqekLGVRIVCSQE 80
gi 156085563   1 MKCVILAGGHGTRLRPLTLTVPKPMIPFCNRPIVEYQIKASKEAGvdHIILAISHEQNNMVPMIkelserCNIRIDCSIE 80
gi 47156979    8 LKALILVGGTGTRLQPITFTTPKPLVPFVNKPMLEHQVEALARVGveEIVLAMNYKYKRIIDAVdnfsgrYGTKITYSLE 87
gi 67601314   30 MKAIILSGGYGSRLRPLTLTKPKSIVELCNIPIIEFQIAQFASIGitEIIVALNYKANELIPTLkiiedrYAVKVHLSIE 109
gi 211962684   1 MKALVLVGGYGTRLRPLTLSVPKPLINFCNKSIVEYQIHSLKKAGvdHVILAVAYQPSTLMDALsaleqkYSLAITCSRE 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 24638016   81 NEPLGTAGPLALARDILakd---------------------------------------------------------hsP 103
gi 124808663  81 DEPLGTGGPLKLAENYLnk----------------------------------------------------------ydD 102
gi 19069594   88 QEPLGTAGPLALAKKYLeg-----------------------------------------------------------hT 108
gi 145512980  81 TEPLGTAGPIRLAKDHIikdn-------------------------------------------------------pdgL 105
gi 71031126   80 STPLGTAGPLRLAKELIcsdd-------------------------------------------------------dsdD 104
gi 159475619  81 KEPMGTAGPLALARETLddg--------------------------------------------------------kgtP 104
gi 156085563  81 KESLGTAGPLKLAKNLIcdpa------------------------------------------------------dnckE 106
gi 47156979   88 KEPLGTAGPIALAREYLsg-----------------------------------------------------------sT 108
gi 67601314  110 EKPLGTAGPIKLAQDFLke----------------------------------------------------------deP 131
gi 211962684  81 DEPLGTAGPIRLAKDLLlspspalasspdgngggaaavvrerpaprdrescqevsaesaaahgdagndqadarggdaedC 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            ###                                                                  #      
gi 24638016  104 FFVLNSDVICEYPF-ADLAAFHKAHG---AEGTIVVTKVEEPSKYGVVVhypnseslIERFVEKPVEFvSNRINGGIYIL 179
gi 124808663 103 FFVFNSDIICTFPL-IEMMNFHKQNK---APLTILVKEVEDPRAFGVVIted---kmITKFEEKPLVPkSSLINAGIYIL 175
gi 19069594  109 FFVLNSDITCRFPL-AEMLSFHYSHG---REGTILSTNVDDPSRYGIIItees-tslVRSFLEKPKDAvSNRVNAGIYIL 183
gi 145512980 106 FFVLNSDIICEFPL-DKLLQFHKQHN---HEGTIFVNEVDDPSKYGVILade--tgrIKDFIEKPQEFiSNKINSGLYLF 179
gi 71031126  105 FVVFNSDIICNYPL-KELLESHRKNS---AKVTILVTTVENSSEFGVILhde--nglIKSFLEKPKNStSNTINAGVYVL 178
gi 159475619 105 FFVLNSDVICDYPL-KDMLDFHKARG---AEATILVTKVDDPTKYGVVVmde--ygqVQRFVEKPKEFvGDKINAGIYVC 178
gi 156085563 107 FLVLNSDIICSYPF-AEMISAHRKNN---ADATILVTKTTHPSDFGVIVhde--tyrIHEFVEKPSQFiSNQINAGIYVL 180
gi 47156979  109 FFVLNSDVICEFPL-DDLLDFHRRTA---RLGTILATTVENPEKFGVIKtrkd-svlVEEFVEKPVVYvGNRVNAGIYVF 183
gi 67601314  132 FFVCNSDIICNFPLrEMLDLYHKKNSdseCNGVILIKQVSDPSKFGVVLhden-tliVEKFIEKPKDFvGDFINAGIYIL 210
gi 211962684 161 FFVCNSDVICPFPF-KEMLAFHKAKG---AEGTILVTEVENPSIYGVVLhde--egrVSDFIEKPQQFvGRCINAGLYIL 234
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                    
gi 24638016  180 NPSVLDRIEP-RPTSIEKEVFPAMVnd----kQLHSFDLEGYWMDVGQPKDYLTGTCLYL 234
gi 124808663 176 NKQILNFIPQ-RNCSLEKEIFPKLAsd----nMLYFYQLNNFWADIGKPLDFLKGQSLYM 230
gi 19069594  184 NPSVLDRIEL-RECSIEREIFPRMAee----hQLQVFDLKGFWMDIGQPADYIKGQGMYL 238
gi 145512980 180 NVSMIDRIPL-KPTSIEREIFPIMAke----gQLYQYILPGFWKDVGQPKDYLAGTVLIL 234
gi 71031126  179 NKEVLDHIPL-KNYSIEKQFFPKYLky----nSSYIYKLDGFWSDIGKPTGYLNGQHLYL 233
gi 159475619 179 SPSILNRIEL-RPTSIEREVFPHVAad----nRLYAYTLNGYWMDVGQPKDYLKGLHLYL 233
gi 156085563 181 NKNMLDYIPD-GSVSIERYLFPTMVam----gRTYCHPLNGLWADIGKPSDYIRAQQLYL 235
gi 47156979  184 ESDVLQYFKS-RPSSIENEVFPLLAtm----qQLCVYELQGFWMDIGTLEGYLKAQRLYL 238
gi 67601314  211 SKRILDLIKPnQQVSIEKDIFPIMAssntlycNKFFTNNENIWADIGNPKDFLLGSKLFM 270
gi 211962684 235 NTSVIDRIQL-RPTSIEKEVFPQMAre----kKLFCFKLDGYWADIGQPKDFLKGMTLHL 289

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