Conserved Protein Domain Family
NTP_transferase_like_2

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cd06426: NTP_transferase_like_2 
NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family.
This is a subfamily of nucleotidyl transferases. Nucleotidyl transferases transfer nucleotides onto phosphosugars. The activated sugars are precursors for synthesis of lipopolysaccharide, glycolipids and polysaccharides. Other subfamilies of nucleotidyl transferases include Alpha-D-Glucose-1-Phosphate Cytidylyltransferase, Mannose-1-phosphate guanyltransferase, and Glucose-1-phosphate thymidylyltransferase.
Statistics
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PSSM-Id: 133048
View PSSM: cd06426
Aligned: 34 rows
Threshold Bit Score: 279.782
Threshold Setting Gi: 125975125
Created: 7-Nov-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Substratemetal binding
Feature 1:Substrate binding site
Evidence:
  • Comment:Putative substrate binding site based on conserved residues of similar proteins.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           ###                                           #                              
gi 83816253  122 VVLMAGGLGTRLRPLTDdcPKPLLEVGDKPILETILEGFIahGFHRFYLSVNYKAGMIEDYFRDGsnwGVDISYVHEEKR 201
gi 146347943 124 VVIMAGGKGTRLHPYTKiiPKALIPIGEIPIIERIINRFLefKFENFYITVNYKKEIIKAYFSKKl--SYKISFLEEKKP 201
gi 125975125 121 VVIMAGGLGTRLYPYTKilPKPLIPIGEIPIAEHIMNRFNkfGCRQFYLILNHKKNTVKAYFNDIe-kNYSVNYVEEEKP 199
gi 33864986  129 IVIMAGGKGKRLMPLTAntPKPMLPVHGKPMLEHILDRLRedGFKNVIISVNYLSERITSYFQDGskfDMNISYLYEDKP 208
gi 83589609  128 VVIMAGGKGTRLDPFTKilPKPMLPLGDKPIVEVLMDRFYdqGFSQFILSVGYKAEVVKLYFNDSngrPYKVNFVQEEEP 207
gi 15792652  119 IIIMAGGLGSRLKELTKdtPKPMLKVGKKPILESIIQRLKnqNFENFIFCVNYKKQIIEDYFQKGqkfGVKISYIKERKK 198
gi 126696743 128 FFILAGGKGLRMRPLTKnlPKPMLHISGKPMIELIINNAKefGFRNFVLSIGYLGEVIKEYFGNGdkfGINISYIQEEKP 207
gi 118443180 122 VFILAGGLGTRLRPLTEkvPKPMLKIGDKPMLERIIKQFKayGFRNFIISINYKGEIIENYFKDGsdfDVNIEYVREEKK 201
gi 53712729  126 IVIMAGGQGTRLKPLTNiiPKPLIPIGEKTFMEDIMDRFVkcGSNNFYVSVNYKADVIKHYFSTLrdsSYRINYFQENVP 205
gi 153808788 131 VVIMAGGKGTRLKPITNviPKPLVPVGDKTILEVIMDQFEgiGCHKFYMSVNYKADMMEYYLSQLd-hKYDIEFFMEDKP 209
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                              # #                                                       
gi 83816253  202 LGTAGPLSLLperp-detMIVMNGDLLTKLNFTHLLDFHREHGAVATMCVREHETQVPYGVIEtdd-qsmEGIEEKPTer 279
gi 146347943 202 LGTAGGLSLVgnsi-gntFFVSNCDILVNANYSKILEYHKEHNNKVTVVTALKNYIIPYGILNlnqkgdiASIDEKPNye 280
gi 125975125 200 LGTGGGLSLLkgki-tstFVLSNCDILIEEDYEKIYSYHKKMNNLITMVCSLKNIKIPYGVVEindkgeiENIKEKPElv 278
gi 33864986  209 LGTAGALSGLdsktrenpVIVTNADILSGISYSDLLIYFRRNTSNGLMAVRTQEWQNPFGVVQsng-shiTNIIEKPThy 287
gi 83589609  208 LGTAGALGLLrqql-qgtFLVTNCDVIIEMNYGELLRYHHEKGNALTIVGALRDFTIPYGVLRtea-gefHQIEEKPSfh 285
gi 15792652  199 LGTAGALSLIkqef-kesFIVMNADILTELDFNALLKAHKKSKALMSVCVREFEQQIPYGVITqkq-gfiENIEEKPTqk 276
gi 126696743 208 LGTAGSLAYLkkdlltdyVFITNGDVVTSLEYSNMLNFAKYTKADGVIAVKEFGLQNPFGVIEtsn-dnfIGISEKPIyk 286
gi 118443180 202 LGTAGSISLAkdkl-kddFIVINGDILTGIDFEELLNYHKENKYDITAGARNYEMRVPYGVMVmkd-kliKSLEEKPTyn 279
gi 53712729  206 LGTAGSLTLMrdki-httFFVSNCDIIINEDYSQILKYHKENKNELTVVAALKNYPIAYGVLYtkengllDSIVEKPDlt 284
gi 153808788 210 LGTIGSVSLLkgki-ttpFFVSNCDSINEQDYRDVYDYHTNNHNDMTIVTMVKSFKIPYGVIEtgedglmVNLKEKPEht 288
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
Feature 1                                                                       
gi 83816253  280 YFVNAGIYVLEPETLGYVPenefFDMPDLFKRLIDEGkeATVFPVr-EYWQDVGRkEDFHRVN 341
gi 146347943 281 FLINTGMYVLEVDVLRYISkgiyFNMTDLINICLSNGekVGIYPVtdNDWLDMGEfREMKSMI 343
gi 125975125 279 YFVNTGLYFAEPKIIEELEenrpVEFPDIIKKYKSRGekIGVYPIseNSWMDMGQfDEMEKMK 341
gi 33864986  288 YQVNAGLYVLDNKLLDLLTpnsyCDMPDLFRMGLEINlnLQVYPLh-EQWLDIGRpKDYDIAN 349
gi 83589609  286 FLVNIGLYVLEPEVLEGLDnssfIHMTDLIMATKDKGlrVGVYPHh-GRWFDIGQwDEYRQTL 347
gi 15792652  277 FLVSAGIYVLENEILNLIAkneyLDMPELIKLVLQKGk-VNTYIIn-DYWIDIGRpDEFLKAN 337
gi 126696743 287 STINAGVYVVSKNLIGLIEkgkhIDMNQLFELGINKKkiLKVFALh-EEWTDVGRpEDYKRIR 348
gi 118443180 280 FYINSGIYVLSKDVVKYIPdnkeYNMTDLIEDIINDNgrCGAYNIt-EYWSDIGHiEDYKKAN 341
gi 53712729  285 FKINTGLYILEPNLLDEIPegqfYHITSLIDKLRKENrrIGVFPVseKSWIDVGNwNEYFSII 347
gi 153808788 289 YMVNSGVYILNPELIDEIPegefFHITHLMEKVKACGgrVGCFPVseDSWKDMGEwPEYLKMI 351

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