Conserved Protein Domain Family
CESA_like_2

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cd06427: CESA_like_2 
CESA_like_2 is a member of the cellulose synthase superfamily.
The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, Glucan Biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of glucan.
Statistics
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PSSM-Id: 133049
View PSSM: cd06427
Aligned: 20 rows
Threshold Bit Score: 396.626
Threshold Setting Gi: 83859655
Created: 10-Nov-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
DXD motif
Feature 1:DXD motif
Evidence:
  • Comment:DXD motif in the catalytic site could be in binding the metal ion that is used to corordinate the phosphates of the NDP-sugar in the active site.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 21109893   61 PVYTVLVPMYKEpEVLPILANALRKLDYPisKLDVKLVLEADDLDTIeaakklgle-affeiirvPPSQPKTKPKACNYA 139
gi 21322891  120 KTYTVLVPAYGEpEVIAQLLASMHAFDYPkhLLQVLLMLEEDDLPTIaaaeaagvd-qvatiikvPPAQPRTKPKACNYG 198
gi 145220812  95 PVYTVLLPVYNEpSIVHNLIAGVGRLEYPkdKLEILLLVEEDDIATRramattel--eavrlilvPNSQPKTKPKACNYG 172
gi 206676348 198 PRVSLLIPLHDEtEILEALLRHIGMLTYPetLLDVILIVEASDTLTRshlettdlp-nwmrilivPAGKITTKPRAMNYA 276
gi 206684629 254 PVISVMVPLYKEaEISRALLTRIRKLSYPraLTDVILVLEEQDSVTRaalentrlppwirvvevpAFGGLTTKPRAMNYA 333
gi 119714968 237 PTYTILVPLYKEaGIVPRLVRDINALDYPrtRLDVKLLCEEDDEETVqrirdlqlp-phfhlvvvPDSQPKTKPKACNYG 315
gi 196184862  82 PRYTILAALHDEaAVVPQLIQRLSKIDYPrrQLEGFLVLEAHDQATIdaakaarrp-gwlrilvvPPGAPKTKPRALNHA 160
gi 83859655  110 PVISVIVALHDEaRVLPGLIAALSRLNYPrsKLDIILALEAHDQPTRaaaralagr-kalrvvvlPPLGPMTKPRALNVA 188
gi 211959023 296 PHYTILVPLYKEsAICRQLVDALDALDYPkeALDVIFLVEQDDELTQknlrkllr--ksmrmiilPPGKPQTKPRALSVG 373
gi 163761290 274 PIYTLLIPLYDEaAMAPALVARIDALRWPksLLDVKYICEAGDEATIealeaqdlg-peceivrvPAFGPRTKPKALQYA 352
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                      ###                                                               
gi 21109893  140 lhf--arGELLTIYDAEDKPEPDQLKRVVAAFrkaekdVVCIQARLNYYNad---eNWLTRMFTLEYTLWFDFYLPaley 214
gi 21322891  199 lhf--atGEIVTIFDAEDMPDPLQLRRVVVAFersasnTVCVQSRLSYRNar---qNLLTAWFTIEYDVWFNFLLPgvmr 273
gi 145220812 173 matpglkGEMVTIYDAEDIPDPLQLRKTVVAFqqlpdnVGCIQARLGYFNee---qNLLTRWFSMEYDQWFGMTLPavea 249
gi 206676348 277 lpf--crGDIIGIYDAEDAPNPDQLSEVVDLFartsekTACIQAVLDFYNar---sNALSRFFAIEYATWFRLILPgiar 351
gi 206684629 334 lnf--crGAIIGVWDAEDAPEADQLAKVAQAFaradskTACVQGVLDYYNpr---tNWISRCFTLEYGSWFRIVLKgmsr 408
gi 119714968 316 lql--atGDYCVIFDAEDRPDPDQLKKAIIAFsrvpenVVCVQAKLNHFNqd---qNMLTAWFANEYSMHFELVLPamga 390
gi 196184862 161 laf--atGELLTIYDAEDEPDPGQLREAASRFagq-pqLGCLQAPLRIRRrnaelsTFLDRQFAFEYAALFEVNLPgmak 237
gi 83859655  189 lqt--arGELVAVYDAEDAPHPDQLRQAAECFaad-drLGIIQAPLGWYNrt---eNWLTAQFALEYATQFNALLPllar 262
gi 211959023 374 laa--tkGEFVTVFDAEDRPEPQQLKKAICQFaleghdVACLQAALSIDHak---dGWLVRQFAFEYAALFDVFLPflsr 448
gi 163761290 353 lrg--arGSLIAVYDAEDKPAPGQLLEAWATFragddqLGCLQAPLAVANlr---sNWISGLFALEYSGLFRVLIPflar 427
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 21109893  215 lripIPLGGTSNHFRLDVLrqvRAWDPYNVTEDADLGVRLIQNGYRVNVVNSTTFEEanVSIPNWIRQRSRWLKGYMQTW 294
gi 21322891  274 mnapVPLGGTSNHLLTGVLkdlGAWDPFNVTEDADLGVRIAAKGYSTAVLDSVTWEEanSDTINWLRQRSRWYKGYLQTW 353
gi 145220812 250 agcvVPLGGTSNHMRTSVWraiGGWDEFNVTEDADLGVRLARAGYRTRILDSVTLEEanSDVLNWIRQRSRWYKGYLQTM 329
gi 206676348 352 mgfaIPLGGTSVFFRRNVLeklDGWDAHNVTEDADLGIRLARAGYQTTLISSVTLEEanNKAWPWIKQRSRWLKGYLITY 431
gi 206684629 409 lglvMPLGGTTMFVRRHVLeelGGWDAHNVTEDADLGVRLYRAGYRTEMLPSTTYEEanCRPWPWVKQRSRWLKGFMLTY 488
gi 119714968 391 aespIPLGGTSNHFVTAKLrelGAWDPFNVTEDADLGIRLHREGYRTAMIDSTTLEEanSQVPNWIRQRSRWNKGYIQTW 470
gi 196184862 238 lnlpFPLGGTSNHLRTAALrrvGGWDAYNVTEDADLGFKLWSAGWRLGVLESPTWEAppGALERWLPQRTRWLKGYMQTW 317
gi 83859655  263 lgwpLPLGGTSNIFRQSALvacGGWDPFNVTEDADLGFRMARSGWRAGLVAPGTLEEapITLRAWTHQRSRWLKGHFITW 342
gi 211959023 449 knllLPLGGTSNHFRVSALrkvGGWDPFNVTEDADLAVRFARQGFRTRTLNSSTYEEapLTLKAWLHQRTRWHKGWIQTL 528
gi 163761290 428 tgmpIPLGGTSNHFKRAALentGGWDPHNVTEDADLGLRLHAYGYRTGILKCATVEScpVQLDVWKRQRTRWLKGWAQTW 507

                 ....*..
Feature 1               
gi 21109893  295 LVHMRDP 301
gi 21322891  354 LVYMRRP 360
gi 145220812 330 LVHLRHP 336
gi 206676348 432 FTHMRRP 438
gi 206684629 489 LVHMRQP 495
gi 119714968 471 LVHMRAP 477
gi 196184862 318 GVHTRAP 324
gi 83859655  343 LVHMRDP 349
gi 211959023 529 AVHLRNP 535
gi 163761290 508 LVAMRNP 514

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