Conserved Protein Domain Family
GT8_HUGT1_C_like

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cd06432: GT8_HUGT1_C_like 
The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family.
C-terminal domain of glycoprotein glucosyltransferase (UGT). UGT is a large glycoprotein whose C-terminus contains the catalytic activity. This catalytic C-terminal domain is highly homologous to Glycosyltransferase Family 8 (GT 8) and contains the DXD motif that coordinates donor sugar binding, characteristic for Family 8 glycosyltransferases. GT 8 proteins are retaining enzymes based on the relative anomeric stereochemistry of the substrate and product in the reaction catalyzed. The non-catalytic N-terminal portion of the human UTG1 (HUGT1) has been shown to monitor the protein folding status and activate its glucosyltransferase activity.
Statistics
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PSSM-Id: 133054
View PSSM: cd06432
Aligned: 15 rows
Threshold Bit Score: 449.147
Threshold Setting Gi: 67478161
Created: 11-Jun-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative ligandmetal binding
Feature 1:putative ligand binding site
Evidence:
  • Comment:annotation is based on homology to other subgroups of the superfamily

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              ###  ##                                                                    
gi 118094837 1230 LNIFSVASGHLYERFLRIMMLSVLKHTk-------tPLKFWFLKNYLSPTFKEFIPYmakkYNFQYELVQYKWPRWLHQQ 1302
gi 57223472  1228 INIFTVASGLLYERFASIMILSVMKHTn-------sSVKFWFIENFLSPTFIAFIPKlaeeYGFQYEFVTYKWPHWLRAQ 1300
gi 28829249  1369 IHIFSVASGHLYERFLKIMMLSVVKNTe-------sPIKFWFLKNYLSPAFKEFIPEmakeYGFQYELVTYKWPWWLRKQ 1441
gi 145337405 1301 INIFSIASGHLYERFLKIMILSVLKNTn-------rPVKFWFIKNYLSPQFKDVIPHmaqeYNFEYELITYKWPSWLHKQ 1373
gi 67477397  1240 INIFSVASGHLYERLLRIMMVSLLKHTk-------sPVKFWFLKNYLSPQFTDFLPHmaseYNFQYELVQYKWPRWLHQQ 1312
gi 115686276 1168 LNIFSLASGHLYERLLRIMMLSVLKHTk-------sPVKFWFLKNYLSPSFKEIIPEmakeYDFEYELIQYKWPRWLHQQ 1240
gi 28920900  1192 INIFSVASGHLYERMLSIMILSVMEHTd-------hSVKFWFIEQFLSPSFKSFLPHlaaeYGFKYEMVAYKWPHWLRHQ 1264
gi 28564471  1164 INIFTVASGHLYERFLSIMTASVMAHTd-------hTVKFWLIENFLSASFKAFLPHlaahYGFEYELVTYQWPHWLRGQ 1236
gi 62360214  1364 LNIFTVASGHLYERFLRIMMHTVMRTSsdvhganttRIKFWLIENFLSPQFKELVPLlaehYGFDVGFVTYRWPWWLNKQ 1443
gi 15214322  1157 INIFSVASGHLYERFLYIMTKSVIEHTd-------kKVKFWFIENFLSPSFKSSIPAiakkYNFEYEYITYNWPHWLRKQ 1229
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    #               # ###                        #                       
gi 118094837 1303 TEKQRIIWGYKILFLDVLFPlavDKILFVDADQIVRTDLKELRdfnldgaPYGYTPFCDSRREMD--GYRFWKSGYWASH 1380
gi 57223472  1301 TEKQRIIWAYKILFLDVLFPmslDKVIFVDADQIVRTDMKELMdvdlhgrVYGYAPMGNSRKEME--GFRFWKSGYWKEA 1378
gi 28829249  1442 TEKQRIIWSYKILFLDVLFPldvPKIIFVDADQVVRTDLKELWdmdlhgaSLGYTPFCDSNKDTE--GFRFWKSGYWRQH 1519
gi 145337405 1374 KEKQRIIWAYKILFLDVIFPlslEKVIFVDADQIIRTDMGELYdmdikgrPLAYTPFCDNNREMD--GYKFWKQGFWKEH 1451
gi 67477397  1313 TEKQRTIWGYKILFLDVLFPlnvRKIIFVDADAIVRTDIKELYdmdlggaPYAYTPFCDSRKEME--GFRFWKQGYWRSH 1390
gi 115686276 1241 TEKQRMIWGYKILFLDVLFPlniKKIIFVDADQIVRADMQELAdfdlkgaPYGYVPFCDSRKEMD--GFRFWKSGYWASH 1318
gi 28920900  1265 SEKQREIWGYKILFLDVLFPlslDKVIFVDADQVVRTDMYDLVsldlegaPYGFTPMCDSRTEME--GFRFWKTGYWANY 1342
gi 28564471  1237 TEKQRQIWGYKILFLDVLFPqdlERVIFIDSDQIVRTDLYELVemdlegaPYGFTPMCDSRKEMD--GFRFWKQGYWDTF 1314
gi 62360214  1444 TEKQRTIWAYKILFLDVLFPlnvDRVIFVDADQIVQADLHELYnmnigaaAMAYTPFCREYPNDAttNFRFWDQGFWLSH 1523
gi 15214322  1230 EEKQREIWGYKILFLDVLFPlelHKVIYVDADQIVRADLQELMdmdlhgaPYGYTPMCDSREEME--GFRFWKKGYWKKF 1307
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                 ###                                   ##                      ##        
gi 118094837 1381 LA-GRKYHISALYVVDLKkFRKIAAGDRLRGQYQGLSQDPNSLSNLDQDLPNNMIHQvpIKSLPQEWLWCETWCDDSSKK 1459
gi 57223472  1379 LR-GRPYHISALYVVDLKkFRQLATGDRLRGQYHALSADPNSLANLDQDLPNSMQDQipIWTLDQDWLWCQTWCSDESLA 1457
gi 28829249  1520 LA-GRSYHISALYVVDLVrFRRLAAGDQLRATYDQLSRDPNSLANLDQDLPNYLQHYvrIHSLPQEWLWCETWCDQESKS 1598
gi 145337405 1452 LR-GRPYHISALYVVDLVkFRETAAGDNLRVFYETLSKDPNSLSNLDQDLPNYAQHTvpIFSLPQEWLWCESWCGNATKA 1530
gi 67477397  1391 LM-GRRYHISALYVVDLKrFRKIAAGDRLRGQYQALSQDPNSLSNLDQDLPNNMIHQvaIKSLPDDWLWCQTWCSDSNFK 1469
gi 115686276 1319 LA-GRKYHISALYVVDLVkFRRIAAGDRLRGQYQALSQDPNSLSNLDQDLPNNMIHQvaIRSLPQEWLYCETWCHESEKS 1397
gi 28920900  1343 LR-GQPYHISALYVVDLRrFRELAAGDRLRQQYHTLSADPNSLANLDQDLPNHMQFQipIKSLPQEWLWCETWCSDETLT 1421
gi 28564471  1315 LGdDLVYHISALFVVDLKvFRAQQIGDRLRVHYHQLSADPASLSNLDQDLPNNLQRQvpIFSLPQDWLWCETWCSDESLK 1394
gi 62360214  1524 LR-GKPYHISALYLVNVQrLRAALGGDKYRATYARLSEDPGSLANLDQDLPNFMQDEmpIFSLPEEWLWCETWCAGESKA 1602
gi 15214322  1308 LR-GLKYHISALYVVDLDrFRKMGAGDLLRRQYQLLSADPNSLSNLDQDLPNHLQHLipIYSLPQDWLWCETWCSDESLK 1386
                         250
                  ....*....|....*...
Feature 1              # ##    #    
gi 118094837 1460 RAKTIDLCNNPMTKEPKL 1477
gi 57223472  1458 TAKTIDLCQNPLTKEPKL 1475
gi 28829249  1599 KAKTIDLCNNPLTKTPKL 1616
gi 145337405 1531 KARTIDLCNNPMTKEPKL 1548
gi 67477397  1470 TAKVIDLCNNPQTKEAKL 1487
gi 115686276 1398 RAKTIDLCNNPLTKEPKL 1415
gi 28920900  1422 KARTIDLCNNPMTKEPKL 1439
gi 28564471  1395 TAKTIDMCNNPLTKEPKL 1412
gi 62360214  1603 RAKTIDLCNNPLTKIPKL 1620
gi 15214322  1387 TAKTIDLCQNPLTKEKKL 1404

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