Conserved Protein Domain Family
GT_2_WfgS_like

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cd06433: GT_2_WfgS_like 
WfgS and WfeV are involved in O-antigen biosynthesis.
Escherichia coli WfgS and Shigella dysenteriae WfeV are glycosyltransferase 2 family enzymes involved in O-antigen biosynthesis. GT-2 enzymes have GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.
Statistics
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PSSM-Id: 133055
View PSSM: cd06433
Aligned: 107 rows
Threshold Bit Score: 179.663
Threshold Setting Gi: 22298559
Created: 18-Nov-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
metal binding
Feature 1:metal binding site
Evidence:
  • Comment:based on homology to other members of the superfamily

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                            #                                            
gi 158520542   20 SIITVVLNGadTLERAIKSVVSQTFrd--fEYIIIDGGSTDGTLDIIRryesh------ltcwiSEPDKGLYDAMNKGVA 91
gi 207090911  420 TIVTPVLNGaqFIEATLRSVLVQEYpa--lEFIIVDGGSTDDTLSIIDsvqnssdfkdriscviSEPDGGMYDAIAKGFS 497
gi 46241626    28 TIITPCLNRaaLVAEAVESVLAQDGvt--vEHIVVDGGSTDGTLEVLAryph--------lrvlTGPDRGVYDAINRGLG 97
gi 193216208   11 SIITPVFNGevFIENCLKNVIEQKCpf--aEHLIMDGGSKDKTVEILKtysqkh----phihfiSEKDNGQSDAMNKGIK 84
gi 110637269   12 SIITPSYNQgaFIERTIKSVLEQNYsn--lEYIIVDGGSTDNTVEIIKkyqdk------ihywiSERDKGTYEANNKALE 83
gi 85704548   165 TVLIATFNAsaDLVATLQSILVQNRtd--iECIIVDGGSRDHTLDIAAawphv------vthcfSHPDKGLYDALNKGLA 236
gi 94967921     7 SIVTPSLNQgpFLRECLKSVAKQGIsv--iEHIVMDGDSTDDSMETLKafeaecr---yplrwqSKRDRGQSDAINKGFK 81
gi 197123558    4 TILTPTLNAerFLPECLQSIRMQSYpasriQHLVLDGHSSDGTVALARasga---------evsVQRDGGLYEAMNRGIR 74
gi 196228835   10 VLAVPVFNGerFLAETLASLNEQGDd---vRWWMQDGASKDGTVEIARrfvrp------cdkivSEPDSGQPDALNRAFQ 80
gi 187736070    8 SIITPSYNYarYVRECIESVKNQEGat--fEHIIQDAGSTDGTLDILHsyph--------lklhVEKDSGMSEGINRGFR 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 158520542   92 LSKGEWVYFLGADDYLldgftsaa---arlkdgtTVYYGNvyrpvadriydg----------------rfsfyklacrnI 152
gi 207090911  498 RATGEILGYLNADDLLeggalaavgsyfsrhpkvAVIYHEdtvlvngwkypnvrq----------pkgintvdllnkhiL 567
gi 46241626    98 IARGSVVGHLNSDDLLlpgaltavaralatapeaDAACGGatvvetgsgldgterpreacgyddpamkrlrpfdlcrgvP 177
gi 193216208   85 MAKGDIISFLNVDDFYepnalndaaaiidkmtepGLLVGNckvwisedkiqrvnkpk-----hlklrdlllgveinehpI 159
gi 110637269   84 KVTGDFWCVVNSDDLLaegalekiaahiqrnpesKWFAGGidyidendavtghfip-------ekpeavngftfidgcwI 156
gi 85704548   237 VARGTLIGIVGAGDCYlpgaldrv--afahysepADVFGGqtierapdgqtrkrk----------depwglnafvsggpV 304
gi 94967921    82 EAKGEIIGWLNADDRYrpgafsavldafrkhpetDVLYGDytwidadgetvqqrre--------igfspfvllyhrvlyI 153
gi 197123558   75 LAGGDVIGWLNGDDAYepgaiaavvdafrqnptaEIVVGDhrmagpegsrlirgra--------ealarlragkrrgawV 146
gi 196228835   81 QMGGEIIGFLNADDTLlpgtarkvldyfaahpdvDLVCGEiewidehsnvtgrhagri---hslaevldiygvwwanrqW 157
gi 187736070   78 KARGKWVMWLNTDDRLlpgalaavkafadsrpdaDIVYGAwnfigpdgeiqramk---------alpyslnmhiwygtyL 148
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
Feature 1                                    # #                                 
gi 158520542  153 CHQSIFYPRCVWkkfs--ynlkYPVFADYDLNLRCFVddgiqf-kyipdtIAVFTDEGGLSPR 212
gi 207090911  568 FQDGVFFRREAYqtigg-lrrdLKLAGDYDLWLRLSArfkfir-rsghvsCFRIRRGQFSENM 628
gi 46241626   178 MINARFFRRSLYervgg-ydpsYRYAGDREFLIRAWTagmktv--pvaerVYLYRQHDGSMTI 237
gi 193216208  160 NPSAYFYHKSLHekigy-ykidEHFAMDIDFIYRAVQyahvk---yvdkiWGNFRSYNDTKTV 218
gi 110637269  157 SHPAVFLSSDLIntig---kfeKYHLMDLNYWLRMELqgyspf--ivhtsLAALRLHKDSKSA 214
gi 85704548   305 GHNGMFATSKAYeqigs-fgyvYPMAEDTRWMHRAIHagcsft--yipepVVLFPLTGMSNNN 364
gi 94967921   154 QTTAMFFHRRVLdagyc-ldesLHYAMDFEFFVRLSAsrhrfl--hvpvfLGDFRFQPKSKTT 213
gi 197123558  147 VPIATFFRAATLrglgp-yrseYRYCADLDLWMRAAArpsppevarvdtvIGSFRVHAGSLSS 208
gi 196228835  158 VQPEVFFRRSLWekagl-fdpkWNLVFDYEFWIRCFRagarva--hlsepLTRFRIHGAQKSA 217
gi 187736070  149 ASTALFLRRSTTieegfllderFHYDMDGEYYARLGRagkkfv--hynrlLADFRWHGDNLSA 209

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